Blocking the Peroxisome Proliferator-Activated Receptor (PPAR): An Overview

Peroxisome proliferator-activated receptor δ

(2013) Lazar A. Bojic et al.   CURRENT OPINION IN LIPIDOLOGY

Synthesis and structure–activity relationships of fibrate-based analogues inside PPARs

(2012) Letizia Giampietro et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fibrate-derived N-(methylsulfonyl)amides with antagonistic properties on PPARα

(2012) Alessandra Ammazzalorso et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Involvement of the peroxisome proliferator-activated receptor (PPAR) alpha in vascular response of endocannabinoids in the bovine ophthalmic artery

(2012) Maria Rosaria Romano et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Examining the safety of PPAR agonists – current trends and future prospects

(2012) Michele Bortolini et al.   Expert Opinion On Drug Safety

Targeting Peroxisome Proliferator-Activated Receptors (PPARs): Development of Modulators

(2012) Céline Pirat et al.   JOURNAL OF MEDICINAL CHEMISTRY

(Z)-2-(2-Bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (DG172): An Orally Bioavailable PPARβ/δ-Selective Ligand with Inverse Agonistic Properties

(2012) Sonja Lieber et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-inflammatory effect of simvastatin in an experimental model of spinal cord trauma: involvement of PPAR-α

(2012) Emanuela Esposito et al.   Journal of Neuroinflammation

Peroxisome Proliferator-Activated Receptor   Mediates Acute Effects of Palmitoylethanolamide on Sensory Neurons

(2012) I. A. Khasabova et al.   JOURNAL OF NEUROSCIENCE

PPAR-alpha is a therapeutic target for chronic lymphocytic leukemia

(2012) D E Spaner et al.   LEUKEMIA

QSAR, QSPR and QSRR in Terms of 3-D-MoRSE Descriptors for In Silico Screening of Clofibric Acid Analogues

(2012) Maurizio Di Tullio et al.   Molecular Informatics

PPARs at the crossroads of lipid signaling and inflammation

(2012) Walter Wahli et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ) Agonists on Glycemic Control, Lipid Profile and Cardiovascular Risk

(2012) Giuseppe Derosa et al.   Current Molecular Pharmacology

PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation

(2011) Tamas Varga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Synthesis and antidyslipidemic activity of chalcone fibrates

(2011) Poonam Shukla et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Benzothiazole-based N-(phenylsulfonyl)amides as a novel family of PPARα antagonists

(2011) Alessandra Ammazzalorso et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

20-Hydroxyeicosatetraenoic acid inhibits ATP-induced COX-2 expression via peroxisome proliferator activator receptor-α in vascular smooth muscle cells

(2011) Chan-Jung Liang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Development of Improved PPARβ/δ Inhibitors

(2011) Philipp M. Toth et al.   ChemMedChem

Hypoxia induces peroxisome proliferator-activated receptor α (PPARα) and lipid metabolism peroxisomal enzymes in human glioblastoma cells

(2011) G. Laurenti et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Palmitoylethanolamide Stimulation Induces Allopregnanolone Synthesis in C6 Cells and Primary Astrocytes: Involvement of Peroxisome-Proliferator Activated Receptor-α

(2011) G. Mattace Raso et al.   JOURNAL OF NEUROENDOCRINOLOGY

HL005—A new selective PPARγ antagonist specifically inhibits the proliferation of MCF-7

(2011) Weiqiang Lu et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

(2011) Jang Hyun Choi et al.   NATURE

Structural and functional insights into nuclear receptor signaling

(2010) Lihua Jin et al.   ADVANCED DRUG DELIVERY REVIEWS

Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway

(2010) Keinosuke Ryu et al.   BMC CANCER

A novel peroxisome proliferator-activated receptor delta antagonist, SR13904, has anti-proliferative activity in human cancer cells

(2010) Nurulain T. Zaveri et al.   CANCER BIOLOGY & THERAPY

Inhibition of peroxisome proliferator-activated receptor γ activity suppresses pancreatic cancer cell motility

(2010) Atsushi Nakajima et al.   CANCER SCIENCE

PPARγ in adipocyte differentiation and metabolism - Novel insights from genome-wide studies

(2010) Rasmus Siersbaek et al.   FEBS LETTERS

The Triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic-acid Methyl Ester Has Potent Anti-diabetic Effects in Diet-induced Diabetic Mice andLeprdb/dbMice

(2010) Pradip K. Saha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and Characterization of 4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a Selective and Irreversible Peroxisome Proliferator-Activated Receptor δ (PPARδ) Antagonist

(2010) Barry G. Shearer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phospholipase D2-Dependent Inhibition of the Nuclear Hormone Receptor PPARγ by Cyclic Phosphatidic Acid

(2010) Tamotsu Tsukahara et al.   MOLECULAR CELL

Palmitoylethanolamide Protects Dentate Gyrus Granule Cells via Peroxisome Proliferator-Activated Receptor-Alpha

(2010) Marco Koch et al.   NEUROTOXICITY RESEARCH

Cyclic phosphatidic acid decreases proliferation and survival of colon cancer cells by inhibiting peroxisome proliferator-activated receptor γ

(2010) Tamotsu Tsukahara et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Antiplatelet Actions of Statins and Fibrates Are Mediated by PPARs

(2009) Ferhana Y. Ali et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Peroxisome proliferator-activated receptor-alpha (PPARα): At the crossroads of obesity, diabetes and cardiovascular disease

(2009) Jean-Charles Fruchart   ATHEROSCLEROSIS

Sorting out the functional role(s) of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) in cell proliferation and cancer

(2009) Jeffrey M. Peters et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Novel biphenylcarboxylic acid peroxisome proliferator-activated receptor (PPAR) δ selective antagonists

(2009) Jun-ichi Kasuga et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and hypolipidemic activity of novel 2-(naphthalen-2-yloxy)propionic acid derivatives as desmethyl fibrate analogs

(2009) Gamal A. Idrees et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Biological Evaluation of 2-Heteroarylthioalkanoic Acid Analogues of Clofibric Acid as Peroxisome Proliferator-Activated Receptor α Agonists

(2009) Letizia Giampietro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Efficacy of PPAR-γ agonist pioglitazone in mild Alzheimer disease

(2009) Tomohiko Sato et al.   NEUROBIOLOGY OF AGING

The role of PPARs in modulating cardiac metabolism in diabetes

(2009) Mark J. Holness et al.   PHARMACOLOGICAL RESEARCH

Significance of peroxisome proliferator-activated receptors in the cardiovascular system in health and disease

(2009) Emma Robinson et al.   PHARMACOLOGY & THERAPEUTICS

Peroxisome proliferator-activated receptor beta/delta (PPARβ/δ) acts as regulator of metabolism linked to multiple cellular functions

(2009) Kay-Dietrich Wagner et al.   PHARMACOLOGY & THERAPEUTICS

Fat and Beyond: The Diverse Biology of PPARγ

(2008) Peter Tontonoz et al.   Annual Review of Biochemistry

PPARδ agonist L-165041 inhibits rat vascular smooth muscle cell proliferation and migration via inhibition of cell cycle

(2008) Hyun-Joung Lim et al.   ATHEROSCLEROSIS

Linoleic Acid-Enriched Phospholipids Act through Peroxisome Proliferator-Activated Receptors α To Stimulate Hepatic Apolipoprotein A-I Secretion†

(2008) Nihar R. Pandey et al.   BIOCHEMISTRY

Cyclic phosphatidic acid — A unique bioactive phospholipid

(2008) Y FUJIWARA   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Inhibition of fatty acid amide hydrolase produces PPAR-α-mediated analgesia in a rat model of inflammatory pain

(2008) D R Sagar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Peroxisome Proliferator-Activated Receptors as Novel Targets in Lung Disease*

(2008) Maria G. Belvisi   CHEST

Tryptophan-containing dipeptide derivatives as potent PPARγ antagonists: Design, synthesis, biological evaluation, and molecular modeling

(2008) Guanghui Deng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

PPAR-β/δ agonists for Type 2 diabetes and dyslipidemia: an adopted orphan still looking for a home

(2008) Andrew N Billin   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Thiazolidinedione derivatives in diabetes and cardiovascular disease: an update

(2008) Pantelis A. Sarafidis   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Discovery of Novel PPAR Ligands by a Virtual Screening Approach Based on Pharmacophore Modeling, 3D Shape, and Electrostatic Similarity Screening

(2008) Patrick Markt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of fatty acid amide hydrolase and cyclooxygenase-2 increases levels of endocannabinoid related molecules and produces analgesia via peroxisome proliferator-activated receptor-alpha in a model of inflammatory pain

(2008) Maulik D. Jhaveri et al.   NEUROPHARMACOLOGY

Identification and Characterization of a Selective Peroxisome Proliferator-Activated Receptor β/δ (NR1C2) Antagonist

(2007) Barry G. Shearer et al.   MOLECULAR ENDOCRINOLOGY