A Chimeric SERM-Histone Deacetylase Inhibitor Approach to Breast Cancer Therapy

Derailed Estrogen Signaling and Breast Cancer: An Authentic Couple

(2013) Bramanandam Manavathi et al.   ENDOCRINE REVIEWS

Targeting the Estrogen Receptor using Steroid–Therapeutic Drug Conjugates (Hybrids)

(2012) Kinh-Luan Dao et al.   BIOCONJUGATE CHEMISTRY

Design, synthesis, modeling, biological evaluation and photoaffinity labeling studies of novel series of photoreactive benzamide probes for histone deacetylase 2

(2012) Aditya Sudheer Vaidya et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthetically Accessible Non-Secosteroidal Hybrid Molecules Combining Vitamin D Receptor Agonism and Histone Deacetylase Inhibition

(2012) Joshua Fischer et al.   CHEMISTRY & BIOLOGY

The enhanced antiproliferative response to combined treatment of trichostatin A with raloxifene in MCF-7 breast cancer cells and its relevance to estrogen receptor β expression

(2012) Zhenzhen Tu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Benzothiophene Selective Estrogen Receptor Modulators Provide Neuroprotection by a Novel GPR30-Dependent Mechanism

(2011) Ramy Abdelhamid et al.   ACS Chemical Neuroscience

Addition of a histone deacetylase inhibitor redirects tamoxifen-treated breast cancer cells into apoptosis, which is opposed by the induction of autophagy

(2011) Scott Thomas et al.   BREAST CANCER RESEARCH AND TREATMENT

A phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancer

(2011) P N Munster et al.   BRITISH JOURNAL OF CANCER

Scriptaid effects on breast cancer cell lines

(2011) L. Giacinti et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Design, Synthesis, Docking, and Biological Evaluation of Novel Diazide-Containing Isoxazole- and Pyrazole-Based Histone Deacetylase Probes

(2011) Raghupathi Neelarapu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides

(2010) Jerome C. Bressi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Biological Evaluation of Triazol-4-ylphenyl-Bearing Histone Deacetylase Inhibitors as Anticancer Agents

(2010) Rong He et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Chimeric Histone Deacetylase Inhibitors: A Series of Lapatinib Hybrides as Potent Inhibitors of Epidermal Growth Factor Receptor (EGFR), Human Epidermal Growth Factor Receptor 2 (HER2), and Histone Deacetylase Activity

(2010) Siavosh Mahboobi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective Estrogen Receptor Modulator Delivery of Quinone Warheads to DNA Triggering Apoptosis in Breast Cancer Cells

(2009) Kuan-wei Peng et al.   ACS Chemical Biology

Phase I trial of vorinostat and doxorubicin in solid tumours: histone deacetylase 2 expression as a predictive marker

(2009) P N Munster et al.   BRITISH JOURNAL OF CANCER

Histone deacetylase inhibitor induced modulation of anti-estrogen therapy

(2009) Scott Thomas et al.   CANCER LETTERS

Explorative Study on Isoform-Selective Histone Deacetylase Inhibitors

(2009) Takayoshi Suzuki   CHEMICAL & PHARMACEUTICAL BULLETIN

A Novel Potent Nicotinamide Phosphoribosyltransferase Inhibitor Synthesized via Click Chemistry

(2009) Giampiero Colombano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and structure–activity relationship of histone deacetylase (HDAC) inhibitors with triazole-linked cap group

(2008) Po C. Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

HDAC family: What are the cancer relevant targets?

(2008) Olaf Witt et al.   CANCER LETTERS

Selective Inhibition of Histone Deacetylase 2 Silences Progesterone Receptor-Mediated Signaling

(2008) E. Bicaku et al.   CANCER RESEARCH

What is triple-negative breast cancer?

(2008) William J. Irvin et al.   EUROPEAN JOURNAL OF CANCER

ERα negative breast cancer cells restore response to endocrine therapy by combination treatment with both HDAC inhibitor and DNMT inhibitor

(2008) Jiang Fan et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

The Protein Data Bank (PDB), Its Related Services and Software Tools as Key Components for In Silico Guided Drug Discovery

(2008) Johannes Kirchmair et al.   JOURNAL OF MEDICINAL CHEMISTRY

Histone deacetylase inhibitor SAHA induces ERα degradation in breast cancer MCF-7 cells by CHIP-mediated ubiquitin pathway and inhibits survival signaling

(2007) Xin Yi et al.   BIOCHEMICAL PHARMACOLOGY

Optimization of biaryl Selective HDAC1&2 Inhibitors (SHI-1:2)

(2007) David J. Witter et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS