Thiadiazole-a Promising Structure in Medicinal Chemistry

Synthesis, biological evaluation, and molecular docking studies of cinnamic acyl 1,3,4-thiadiazole amide derivatives as novel antitubulin agents

(2012) Xian-Hui Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of isoxazolo[4,5-d]pyridazin-4-(5H)-one analogues as potent anti-inflammatory agents

(2012) Keriman Özadalı et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel imidazo[2,1-b][1,3,4]thiadiazole carrying rhodanine-3-acetic acid as potential antitubercular agents

(2012) Shankar G. Alegaon et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of Novel 1,2,4-Thiadiazole Derivatives as Potent, Orally Active Agonists of Sphingosine 1-Phosphate Receptor Subtype 1 (S1P1)

(2012) Feng Ren et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Anticholinesterase Activity and Cytotoxicity of Novel Amide Derivatives

(2011) Mehlika Dilek Altintop et al.   ARCHIV DER PHARMAZIE

Optimizing thiadiazole analogues of resveratrol versus three chemopreventive targets

(2011) Abdelrahman S. Mayhoub et al.   BIOORGANIC & MEDICINAL CHEMISTRY

One-pot synthesis and anticancer studies of 2-arylamino-5-aryl-1,3,4-thiadiazoles

(2011) Dalip Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of 3-heteroarylthioquinoline derivatives and their in vitro antituberculosis and cytotoxicity studies

(2011) Selvam Chitra et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent progress in biological activities of synthesized phenothiazines

(2011) Krystian Pluta et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and anticancer evaluation of novel 2-cyclopropylimidazo[2,1-b][1,3,4]-thiadiazole derivatives

(2011) Malleshappa N. Noolvi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of novel 2-aralkyl-5-substituted-6-(4′-fluorophenyl)-imidazo[2,1-b][1,3,4]thiadiazole derivatives as potent anticancer agents

(2011) Subhas S. Karki et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

In Vitro and In Vivo Activities of 1,3,4-Thiadiazole-2-Arylhydrazone Derivatives of Megazol against Trypanosoma cruzi

(2010) K. Salomao et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

5-Nitroimidazole-based 1,3,4-Thiadiazoles: Heterocyclic Analogs of Metronidazole as Anti-Helicobacter pylori Agents

(2010) Mohammad Hassan Moshafi et al.   ARCHIV DER PHARMAZIE

Novel C-aryl glucoside SGLT2 inhibitors as potential antidiabetic agents: 1,3,4-Thiadiazolylmethylphenyl glucoside congeners

(2010) Junwon Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of 2-(4-((1H-1,2,4-triazol-1-yl)methyl)-5-(4-bromophenyl)-1-(2-chlorophenyl)-1H-pyrazol-3-yl)-5-tert-butyl-1,3,4-thiadiazole (GCC2680) as a potent, selective and orally efficacious cannabinoid-1 receptor antagonist

(2010) Jinhwa Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design and synthesis of anti-breast cancer agents from 4-piperazinylquinoline: A hybrid pharmacophore approach

(2010) V. Raja Solomon et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors

(2010) Balendu Sankara Avvaru et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Sulfonamide-1,2,4-thiadiazole Derivatives as Antifungal and Antibacterial Agents: Synthesis, Biological Evaluation, Lipophilicity, and Conformational Studies

(2010) Charalabos Camoutsis et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Design and Synthesis of Thiadiazoles and Thiazoles Targeting the Bcr-Abl T315I Mutant: from Docking False Positives to ATP-Noncompetitive Inhibitors

(2010) Marco Radi et al.   ChemMedChem

Synthesis and antiviral activity of new acrylamide derivatives containing 1,2,3-thiadiazole as inhibitors of hepatitis B virus replication

(2010) Wei-Li Dong et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antimicrobial evaluation of some fused heterocyclic [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives

(2010) Gabriela Laura Almajan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cyclization of some carbothioamide derivatives containing antipyrine and triazole moieties and investigation of their antimicrobial activities

(2010) Hacer Bayrak et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and anticancer activity of 5-(3-indolyl)-1,3,4-thiadiazoles

(2010) Dalip Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of anti-Toxoplasma gondii and antimicrobial activities of thiosemicarbazides, 4-thiazolidinones and 1,3,4-thiadiazoles

(2010) André P. Liesen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, antioxidant activities and urease inhibition of some new 1,2,4-triazole and 1,3,4-thiadiazole derivatives

(2010) Imtiaz Khan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Insecticidal Activity ofN-tert-Butyl-N,N′-diacylhydrazines Containing 1,2,3-Thiadiazoles

(2010) Huan Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Thiadiazole Carbamates: Potent Inhibitors of Lysosomal Acid Lipase and Potential Niemann−Pick Type C Disease Therapeutics

(2010) Anton I. Rosenbaum et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and preliminary screening of benzothiazol-2-yl thiadiazole derivatives for anticonvulsant activity

(2009) Nadeem Siddiqui et al.   ACTA PHARMACEUTICA

Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB

(2009) Özlen Güzel et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and optimization of thiadiazole derivatives as a novel class of substrate competitive c-Jun N-terminal kinase inhibitors

(2009) Surya K. De et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors

(2009) Dmitry O. Koltun et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438)

(2009) Serge Léger et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Recent developments in the design and synthesis of hybrid molecules basedon aminoquinoline ring and their antiplasmodial evaluation

(2009) Vladimir V. Kouznetsov et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A 4-aminoquinoline derivative that markedly sensitizes tumor cell killing by Akt inhibitors with a minimum cytotoxicity to non-cancer cells

(2009) Changkun Hu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Structure−Activity Relationship of Substrate Competitive, Selective, and in Vivo Active Triazole and Thiadiazole Inhibitors of the c-Jun N-Terminal Kinase

(2009) Surya K. De et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Biological Activity of Some New 1,3,4-Thiadiazole and 1,2,4-Triazole Compounds Containing a Phenylalanine Moiety

(2009) Mihaela Moise et al.   MOLECULES

Effects of novel antituberculosis agents on OmpF channel activity

(2008) H. Mahdiuni et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Novel potent and selective Ca2+ release-activated Ca2+ (CRAC) channel inhibitors. Part 3: Synthesis and CRAC channel inhibitory activity of 4′-[(trifluoromethyl)pyrazol-1-yl]carboxanilides

(2008) Yasuhiro Yonetoku et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The efficacy and selectivity of tumor cell killing by Akt inhibitors are substantially increased by chloroquine

(2008) Changkun Hu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and in vitro anti-leishmanial activity of 1-[5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-yl]- and 1-[5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl]-4-aroylpiperazines

(2008) Mina Behrouzi-Fardmoghadam et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design and synthesis of some thiazolyl and thiadiazolyl derivatives of antipyrine as potential non-acidic anti-inflammatory, analgesic and antimicrobial agents

(2008) Sherif A.F. Rostom et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and anti-Helicobacter pylori activity of 5-(nitroaryl)-1,3,4-thiadiazoles with certain sulfur containing alkyl side chain

(2008) Alireza Foroumadi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Carbonic anhydrase inhibitors: 2-Substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV

(2008) Fatma-Zohra Smaine et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Cytotoxic Evaluation of Novel Dimethyl [1,1′-Biphenyl]-2,2′-dicarboxylates Bearing 1,3,4-Thiadiazole Moieties

(2008) Xiang-Wen Kong et al.   CHEMISTRY & BIODIVERSITY

Synthesis and in vitro anti-Helicobacter pylori activity of N-[5-(5-nitro-2-heteroaryl)-1,3,4-thiadiazol-2-yl]thiomorpholines and related compounds

(2008) Javad Mirzaei et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antimicrobial studies of novel methylene bridged benzisoxazolyl imidazo[2,1-b][1,3,4]thiadiazole derivatives

(2008) Ravi S. Lamani et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Dapagliflozin: A Potent, Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes

(2008) Wei Meng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hybrid Molecules with a Dual Mode of Action: Dream or Reality?†

(2007) Bernard Meunier   ACCOUNTS OF CHEMICAL RESEARCH

Carbonic anhydrase inhibitors: Copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII

(2007) Marouan Rami et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents

(2007) Marco Radi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and CNS depressant activity of some novel 3-[5-substituted 1,3,4-thiadiazole-2-yl]-2-styryl quinazoline-4(3H)-ones

(2007) Varsha Jatav et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

N-{[(6-Substituted-1,3-benzothiazole-2-yl)amino]carbonothioyl}-2/4-substituted benzamides: Synthesis and pharmacological evaluation

(2007) Arpana Rana et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY