Design, Synthesis, and in vitro Antifungal Activity of 1-[(4-Substituted-benzyl)methylamino]-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ols

Improved Model of Lanosterol 14α-Demethylase by Ligand-Supported Homology Modeling: Validation by Virtual Screening and Azole Optimization

(2010) Chunquan Sheng et al.   ChemMedChem

Screening for amino acid substitutions in the Candida albicans Erg11 protein of azole-susceptible and azole-resistant clinical isolates: new substitutions and a review of the literature

(2010) Florent Morio et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Structural Basis of Human CYP51 Inhibition by Antifungal Azoles

(2010) Natallia Strushkevich et al.   JOURNAL OF MOLECULAR BIOLOGY

Three-Dimensional Model of Lanosterol 14 -Demethylase from Cryptococcus neoformans: Active-Site Characterization and Insights into Azole Binding

(2009) C. Sheng et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Design of new antifungal agents: synthesis and evaluation of 1-[(1H-indol-5-ylmethyl)amino]-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols

(2009) Rémi Guillon et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New generation azole antifungals in clinical investigation

(2009) Corrado Girmenia   EXPERT OPINION ON INVESTIGATIONAL DRUGS

New triazoles and echinocandins: mode of action,in vitroactivity and mechanisms of resistance

(2009) Maria Teresa Fera et al.   Expert Review of Anti-Infective Therapy

Antifungal drug resistance mechanisms in fungal pathogens from the perspective of transcriptional gene regulation

(2009) Dominique Sanglard et al.   FEMS YEAST RESEARCH

Regulation of multidrug resistance in pathogenic fungi

(2009) Joachim Morschhäuser   FUNGAL GENETICS AND BIOLOGY

Crystal Structures of Trypanosoma brucei Sterol 14α-Demethylase and Implications for Selective Treatment of Human Infections

(2009) Galina I. Lepesheva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolutionary trace analysis of CYP51 family: implication for site-directed mutagenesis and novel antifungal drug design

(2009) Chunquan Sheng et al.   JOURNAL OF MOLECULAR MODELING

Design, synthesis, and evaluation of 1-(N-benzylamino)-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents

(2008) Francis Giraud et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and structure–activity relationships of 2-phenyl-1-[(pyridinyl- and piperidinylmethyl)amino]-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents

(2008) Francis Giraud et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Isavuconazole: a new and promising antifungal triazole for the treatment of invasive fungal infections

(2008) Jesús Guinea et al.   Future Microbiology

β-N-Biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors: Part 1. Design, synthesis, and lead identification

(2007) Shyh-Ming Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Resistance to Antifungal Agents: Mechanisms and Clinical Impact

(2007) Z. A. Kanafani et al.   CLINICAL INFECTIOUS DISEASES

New and emerging treatments for fungal infections

(2007) A. C. Pasqualotto et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY