Reactions of Antimalarial Peroxides with Each of Leucomethylene Blue and Dihydroflavins: Flavin Reductase and the Cofactor Model Exemplified

Heme as Trigger and Target for Trioxane-Containing Antimalarial Drugs†

(2010) Bernard Meunier et al.   ACCOUNTS OF CHEMICAL RESEARCH

Identification of a 1,2,4,5-Tetraoxane Antimalarial Drug-Development Candidate (RKA 182) with Superior Properties to the Semisynthetic Artemisinins

(2010) Paul M. O'Neill et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Facile Oxidation of Leucomethylene Blue and Dihydroflavins by Artemisinins: Relationship with Flavoenzyme Function and Antimalarial Mechanism of Action

(2010) Richard K. Haynes et al.   ChemMedChem

An alignment independent 3D QSAR study of the antiproliferative activity of 1,2,4,5-tetraoxanes

(2010) Ilija N. Cvijetić et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Molecular Mechanism of Action of Artemisinin—The Debate Continues

(2010) Paul M. O’Neill et al.   MOLECULES

Artemisone and Artemiside Control Acute and Reactivated Toxoplasmosis in a Murine Model

(2009) I. R. Dunay et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Interaction of Artemisinins with Oxyhemoglobin Hb-FeII, Hb-FeII, CarboxyHb-FeII, Heme-FeII, and Carboxyheme FeII: Significance for Mode of Action and Implications for Therapy of Cerebral Malaria

(2009) Paolo Coghi et al.   ChemMedChem

The ferredoxin-NADP+reductase/ferredoxin electron transfer system ofPlasmodium falciparum

(2009) Emanuela Balconi et al.   FEBS Journal

Fre Is the Major Flavin Reductase Supporting Bioluminescence fromVibrio harveyiLuciferase inEscherichia coli

(2009) Zachary T. Campbell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modular Synthesis and in Vitro and in Vivo Antimalarial Assessment of C-10 Pyrrole Mannich Base Derivatives of Artemisinin

(2009) Bénédicte Pacorel et al.   JOURNAL OF MEDICINAL CHEMISTRY

New medicines to improve control and contribute to the eradication of malaria

(2009) Timothy N. C. Wells et al.   NATURE REVIEWS DRUG DISCOVERY

A Broadly Applicable Mild Method for the Synthesis ofgem-Diperoxides from Corresponding Ketones or 1,3-Dioxolanes

(2009) Yun Li et al.   ORGANIC LETTERS

Computational and experimental studies on the catalytic mechanism of biliverdin-IXβ reductase

(2008) Liam J. Smith et al.   BIOCHEMICAL JOURNAL

Two-Step Synthesis of Achiral Dispiro-1,2,4,5-tetraoxanes with Outstanding Antimalarial Activity, Low Toxicity, and High-Stability Profiles†

(2008) Gemma L. Ellis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cytotoxic interactions of methylene blue with trypanosomatid-specific disulfide reductases and their dithiol products

(2008) Kathrin Buchholz et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Broadly Applicable Synthesis of 1,2,4,5-Tetraoxanes

(2008) Prasanta Ghorai et al.   ORGANIC LETTERS

Artemisinins: their growing importance in medicine

(2008) Sanjeev Krishna et al.   TRENDS IN PHARMACOLOGICAL SCIENCES