Total Synthesis of Tubulysin U and Its C-4 Epimer

Guaianolide Sesquiterpene Lactones, a Source To Discover Agents That Selectively Inhibit Acute Myelogenous Leukemia Stem and Progenitor Cells

(2012) Quan Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Flexible and Stereoselective Synthesis of Azetidin-3-ones through Gold-Catalyzed Intermolecular Oxidation of Alkynes

(2011) Longwu Ye et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Acid mediated formation of an N-acyliminium ion from tubulysins: A new methodology for the synthesis of natural tubulysins and their analogs

(2011) Iontcho R. Vlahov et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Syntheses and Evaluation of Simplified Pretubulysin Analogues

(2011) Jens L. Burkhart et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

The Multiple Multicomponent Approach to Natural Product Mimics: Tubugis, N-Substituted Anticancer Peptides with Picomolar Activity

(2011) Orlando Pando et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Synthesis of Amines by the Knochel-Type MgCl2-Enhanced Addition of Benzyl Zinc Reagents toN-tert-Butanesulfinyl Aldimines

(2011) Andrew W. Buesking et al.   ORGANIC LETTERS

The Tubulin-Bound Structure of the Antimitotic Drug Tubulysin

(2010) Karel Kubicek et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and biological evaluation of tubulysin D analogs related to stereoisomers of tubuvaline

(2010) Taku Shibue et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Applications oftert-Butanesulfinamide

(2010) MaryAnn T. Robak et al.   CHEMICAL REVIEWS

Total Syntheses of Tubulysins

(2010) Taku Shibue et al.   CHEMISTRY-A EUROPEAN JOURNAL

One-Pot Synthesis of Chiral α-Methylene-γ-lactams with Excellent Diastereoselectivities and Enantioselectivities

(2010) An Shen et al.   ORGANIC LETTERS

Pretubulysin, a Potent and Chemically Accessible Tubulysin Precursor fromAngiococcus disciformis

(2009) Angelika Ullrich et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and Biological Evaluation of Pretubulysin and Derivatives

(2009) Angelika Ullrich et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Toward Tubulysin: Gram-Scale Synthesis of Tubuvaline-Tubuphenylalanine Fragment

(2009) Srivari Chandrasekhar et al.   JOURNAL OF ORGANIC CHEMISTRY

First Total Synthesis of Tubulysin B

(2009) Orlando Pando et al.   ORGANIC LETTERS

Stereoselective synthesis of tubuvaline methyl ester and tubuphenylalanine, components of tubulysins, tubulin polymerization inhibitors

(2009) Taku Shibue et al.   TETRAHEDRON LETTERS

Tubulysin analogs incorporating desmethyl and dimethyl tubuphenylalanine derivatives

(2008) Ranganathan Balasubramanian et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cytotoxic Simplified Tubulysin Analogues

(2008) Bhooma Raghavan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Total Synthesis and Biological Evaluation of Tubulysin U, Tubulysin V, and Their Analogues

(2008) Ranganathan Balasubramanian et al.   JOURNAL OF MEDICINAL CHEMISTRY

Expedient Synthesis ofN-Methyl Tubulysin Analogues with High Cytotoxicity

(2008) Andrew W. Patterson et al.   JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Synthesis of Acyclic 1,3-Amino Alcohols by Reduction ofN-Sulfinyl β-Amino Ketones. Formal Synthesis of (−)-Pinidinol and (+)- Epipinidinol†

(2008) Franklin A. Davis et al.   JOURNAL OF ORGANIC CHEMISTRY

Remarkable Salt Effect on In-Mediated Allylation ofN-tert-Butanesulfinyl Imines in Aqueous Media:  Highly Practical Asymmetric Synthesis of Chiral Homoallylic Amines and Isoindolinones

(2008) Xing-Wen Sun et al.   ORGANIC LETTERS