Heterocycle-linked Phenylbenzyl Amides as Novel TRPV1 Antagonists and Their TRPV1 Binding Modes: Constraint-Induced Enhancement of In Vitro and In Vivo Activities

Structural insights into transient receptor potential vanilloid type 1 (TRPV1) from homology modeling, flexible docking, and mutational studies

(2011) Jin Hee Lee et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Synthesis and biological evaluation of 5-substituted and 4,5-disubstituted-2-arylamino oxazole TRPV1 antagonists

(2010) Richard J. Perner et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists

(2010) Natalie A. Hawryluk et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

1,2-Diamino-ethane-substituted-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepines as TRPV1 antagonists with improved properties

(2010) Alec D. Lebsack et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pyrido[2,3-b]pyrazines, discovery of TRPV1 antagonists with reduced potential for the formation of reactive metabolites

(2010) Kevin J. Hodgetts et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of Novel 6,6-Heterocycles as Transient Receptor Potential Vanilloid (TRPV1) Antagonists

(2010) Charles A. Blum et al.   JOURNAL OF MEDICINAL CHEMISTRY

TRPV1: On the Road to Pain Relief

(2010) Andres Jara-Oseguera et al.   Current Molecular Pharmacology

Design, synthesis, and biological evaluation of phenylpropanamides as novel transient receptor potential valnilloid 1 antagonists

(2009) Fu-Nan Li et al.   ARCHIVES OF PHARMACAL RESEARCH

Synthesis and structural optimization of multiple H-bonding region of diarylalkyl (thio)amides as novel TRPV1 antagonists

(2009) Fu-Nan Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis, and biological evaluation of novel diarylalkyl amides as TRPV1 antagonists

(2009) Fu-Nan Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Vanilloid Receptor Antagonists: Emerging Class of Novel Anti-Inflammatory Agents for Pain Management

(2009) Manojit Pal et al.   CURRENT PHARMACEUTICAL DESIGN

The pKBHXDatabase: Toward a Better Understanding of Hydrogen-Bond Basicity for Medicinal Chemists

(2009) Christian Laurence et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tetrahydropyridine-4-carboxamides as novel, potent transient receptor potential vanilloid 1 (TRPV1) antagonists

(2008) Brian S. Brown et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Aminoquinazolines as TRPV1 antagonists: Modulation of drug-like properties through the exploration of 2-position substitution

(2008) Charles A. Blum et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Substituted aryl pyrimidines as potent and soluble TRPV1 antagonists

(2008) Markian M. Stec et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

N-Pyridin-3-yl- and N-quinolin-3-yl-benzamides: Modulators of Human Vanilloid Receptor 1 (TRPV1)

(2008) Michele C. Jetter et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and synthesis of 6-phenylnicotinamide derivatives as antagonists of TRPV1

(2008) Susan M. Westaway et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

4-Aminopyrimidine tetrahydronaphthols: A series of novel vanilloid receptor-1 antagonists with improved solubility properties

(2008) Elizabeth M. Doherty et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of piperidine carboxamide TRPV1 antagonists

(2008) Wing S. Cheung et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Recent Progress in the Development of Selective TRPV1 Antagonists for Pain

(2008) Lisa Broad et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Clinical development of TRPV1 antagonists: targeting a pivotal point in the pain pathway

(2008) Martin J. Gunthorpe et al.   DRUG DISCOVERY TODAY

Design and Synthesis of Peripherally Restricted Transient Receptor Potential Vanilloid 1 (TRPV1) Antagonists

(2008) Nuria Tamayo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of benzamide derivatives as TRPV1 antagonists

(2007) Yuji Shishido et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Stereospecific High-affinity TRPV1 Antagonists: ChiralN-(2-Benzyl-3-pivaloyloxypropyl) 2-[4-(methylsulfonylamino)phenyl]propionamide Analogues

(2007) HyungChul Ryu et al.   JOURNAL OF MEDICINAL CHEMISTRY