Article
Chemistry, Analytical
Fanpeng Ran, Yixuan Xu, Minrui Ma, Xiaoyan Liu, Haixia Zhang
Summary: A new nanoenzyme platform was constructed by utilizing the peroxidase-like activity of gold nanoclusters (Au-NCs) in the presence of heparin. A colorimetric method was developed for the detection of heparin based on the enhanced catalytic activity of Au-NCs. The presence of protamine inhibited the catalytic activity of Au-NCs, leading to the development of a colorimetric method for the detection of protamine.
Article
Chemistry, Analytical
Shrishti P. Pandey, Pamela Jha, Dinesh N. Nadimetla, Sheshanath Bhosale, Prabhat K. Singh
Summary: This study successfully utilized tetrapyridinium-tetraphenylethylene (TPy-TPE) as a fluorescent probe for detecting heparin, showing improved sensitivity and performance. TPy-TPE also detected the antidote and degrading enzyme of heparin.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Minglu Yan, Ruiduo Wang, Qiang Wang, Yansong Li, Beibei Liu, Yangyang Li, Man Jiang
Summary: This article presents a label-free, selective, and rapid optical fiber interferometer biosensor for detecting protamine. The thickness of the coating layer is found to be a key factor in the sensor's performance. The proposed biosensor exhibits high sensitivity and stability, making it suitable for protamine detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Lihua Liu, Jianan Dai, Yuan Ji, Baoxing Shen, Xing Zhang, Robert J. Linhardt
Summary: The BZA-BOD@ZIF-90 probe designed in this study can selectively detect protamine with low detection limit and without interference from other substances. It offers a simpler method to obtain accurate determination of protamine. The fluorescence response of the nanocomposite to protamine spiked in human serum suggests potential clinical applications in medical fields involving protamine and heparin.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Cardiac & Cardiovascular Systems
Paul Y. Lee, Juan Bello, Catherine Ye, Shruti Varadarajan, Afif Hossain, Saahil Jumkhawala, Abhishek Sharma, Joseph Allencherril
Summary: This study aimed to determine the safety and efficacy of protamine in reversing heparin during percutaneous coronary intervention (PCI). The analysis of 11 studies revealed that the use of protamine in patients treated with dual antiplatelet therapy (DAPT) can facilitate earlier sheath removal, reduce major bleeding complications, and shorten hospitalization duration without an increased risk of stent thrombosis.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Dibya Kanti Mal, Padma Nilaya Jonnalgadda, Goutam Chakraborty
Summary: A method utilizing the aggregation induced emission phenomenon of ANS dye for the accurate and selective detection of protamine is introduced. The method has high selectivity and sensitivity, with a detection limit of 4.05 nM for protamine and 36 nM for heparin.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Analytical
Shrishti P. Pandey, Pamela Jha, Prabhat K. Singh
Summary: In this study, a tetracationic porphyrin based probe was developed for the detection of Heparin in 100% serum matrix with a clinically relevant LOD and high selectivity. The probe also showed potential for detecting Protamine.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Applied
Jingwen Li, Yongming Liu, Hao Lin, Yan Chen, Zhenbo Liu, Xuming Zhuang, Chunyuan Tian, Xiuli Fu, Lingxin Chen
Summary: A label-free colorimetric method based on Exo I-assisted signal amplification with protamine as a medium was developed for analysis of kanamycin. The method, which involved manipulating a dsDNA probe tailored from an aptamer and cDNA, demonstrated high selectivity and sensitivity for target detection. The strategy showed great potential for fabricating various biosensors based on target-induced aptamer configuration changes.
Article
Chemistry, Multidisciplinary
Yongkai Lu, Yangyang Zhou, Junjie Xia, Suyun Zhong, Yawen Liu, Qiang Chen, Hongxia Chen
Summary: A facile synthetic strategy is used to construct raspberry-like gold nanoparticles, which are then used to develop an efficient and sensitive electrochemical sensor for the detection of Cr(VI). The sensor exhibits a wide linear range and an extremely low detection limit, suggesting potential applications in other ultrasensitive electrochemical sensors.
Article
Hematology
Jecko Thachil
Summary: Protamine has been recognized as a key heparin neutralizing agent, with successful applications in various medical fields. Initially discovered over a century ago, it gained prominence during the insulin era when used to create the neutral protamine Hagedorn formulation. The journey from protamine's discovery to its utilization in gene therapy highlights its versatile applications and importance in medical advancements.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2022)
Article
Chemistry, Multidisciplinary
Robin Nussbaum, Kye J. Robinson, Yoshiki Soda, Eric Bakker
Summary: A novel optical nanosensing principle was proposed to accurately quantify the levels of protamine and heparin in blood samples, overcoming the interference from red blood cells.
Article
Biochemistry & Molecular Biology
Tong Li, Zhiyun Meng, Xiaoxia Zhu, Hui Gan, Ruolan Gu, Zhuona Wu, Taoyun Liu, Peng Han, Jiarui Gao, Su Han, Guifang Dou
Summary: R15, a potential UFH antagonist, shows lower side effects compared to PS and can neutralize the effects of UFH in a nonimmunogenic and potentially safe manner.
Article
Chemistry, Organic
Dibya Kanti Mal, Rajani Kant Chittela, Goutam Chakraborty
Summary: This paper discusses the modulation of a monomer-aggregate equilibrium of the coumarin-7 (C7) dye under the influence of a multi-anionic polymer, poly(styrene sulfonate) (PSS), leading to significant changes in its ratiometric optical signal. The study found that the stability of the C7-PSS complex decreased at pH levels above 5, indicating a decline in the electrostatic attraction between C7 and PSS. The ratiometric response of the C7-PSS assembly showed excellent selectivity towards the polypeptide protamine (Pr), making it a potential candidate for its quantification even in complex biological media.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Analytical
Khalid Alhazzani, A. Z. Alanazi, Ali M. Alaseem, Saeed Abdullah Al Awadh, Saleh A. Alanazi, Abdulaziz Abdullah AlSayyari, Mohammed M. Alanazi, Mohamed M. El- Wekil
Summary: A reliable, selective, and sensitive ratiometric fluorescence sensor was developed for the detection of protamine and heparin. The sensor utilizes Acid Red 87 as the anionic dye and polyethyleneimine modified carbon quantum dots as cationic fluorescent nanoparticles to achieve a ratiometric response.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Analytical
Jana Hovancova, Veronika Niscakova, Ivana Sisolakova, Renata Orinakova, Iveta Maskal'ova, Andrej Orinak, Karol Koval
Summary: Gold microelectrodes modified with gold nanostructures serve as an ideal substrate for non-enzymatic glucose detection, demonstrating excellent electrocatalytic activity and high sensitivity for glucose detection in a miniaturized system.
Article
Chemistry, Physical
Debanjali Ghosh, Mopidevi Manikanta Kumar, C. Retna Raj, Debabrata Pradhan
Summary: In this study, CeO2 nanospheres embedded in NiO nanoflakes were synthesized and demonstrated to have bifunctional activity for the oxygen evolution reaction and oxygen reduction reaction (OER/ORR). The CeO2/NiO-2 nanocomposite showed outstanding OER/ORR activity and stability compared to other compositions and benchmark catalysts. The unique morphology of CeO2 nanospheres embedded in NiO nanoflakes facilitated the exposure of active sites with the bifunctional nature of the catalyst. The electronic synergy between CeO2 and NiO contributed to the formation of oxygen vacancy defects and accessible active sites.
ACS APPLIED ENERGY MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Sourav Mallick, Venkata Surya Kumar Choutipalli, Saheb Bag, Venkatesan Subramanian, C. Retna Raj
Summary: The rational defect engineering of Mn-based spinel cathode materials by metal-ion doping and vacancy creation improves the performance and cycling stability of aqueous rechargeable zinc-ion batteries. The defect-engineered ternary spinel cathode based on Zn, Ni, and Mn shows enhanced Zn2+ ion storage performance with a specific capacity as high as 265 mAh g(-1), and a 2-fold enhancement in specific capacity after 5000 cycles.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
Ashmita Biswas, Ramendra Sundar Dey
Summary: Using advanced catalysts RuO2 and FePc, this study reveals that both the electrode and electrolyte help enhance the thermodynamic properties of the reaction mechanism, thus reinforcing the electrochemical nitrogen reduction reaction (NRR). The findings emphasize the importance of electrode-electrolyte improvisation and provide a wider outlook for determining the efficiency of the overall NRR coupled OER process in terms of different thermodynamic parameters.
JOURNAL OF CHEMICAL PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Ashmita Biswas, Bikram Ghosh, Ramendra Sundar Dey
Summary: Ammonia is considered as the future fuel due to its advantages over liquid hydrogen. The current research trend focuses on electrochemical ammonia synthesis for sustainable and green production. However, the widely used colorimetric indophenol blue method lacks a proper experimental protocol.
Article
Chemistry, Multidisciplinary
Navpreet Kamboj, Bharat Bhushan Upreti, Nitish Kumar, Ramendra Sundar Dey
Summary: In this study, MnO2 nanoflowers and polypyrrole nanoparticles were uniformly grown on a conducting laser-irradiated graphene network. A high-performing rechargeable Zn-MnO2 battery system was successfully developed, along with a novel battery-supercapacitor hybrid system utilizing graphene@polypyrrole as a supercapacitive electrode and graphene@manganese dioxide as a battery electrode. These systems exhibited high energy density and promising storage capabilities.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Review
Chemistry, Multidisciplinary
Loknath Thapa, C. Retna Raj
Summary: The electrochemical activation of dinitrogen for ammonia synthesis is a topic of increasing interest. However, the faradaic efficiency and ammonia yield achieved so far are not suitable for industrial-scale production. The challenges include the competing hydrogen evolution reaction and poor nitrogen solubility. To improve efficiency, various electrolyte engineering strategies have been proposed, including pH control, proton transport velocity manipulation, and use of different electrolyte media. Promising results have been achieved with hybrid and non-aqueous electrolytes, but further research is needed to address the remaining challenges.
Article
Chemistry, Inorganic & Nuclear
Ashmita Biswas, Bikram Ghosh, Kathi Sudarshan, Santosh K. Gupta, Ramendra Sundar Dey
Summary: Extensive research on electrochemical nitrogen reduction reaction (NRR) has identified the Mg-based electrocatalyst Mg2B2O5 as a promising catalyst for NH3 production. The catalyst's abundance of Lewis acid sites promotes bonding-antibonding interactions with N-2 molecules, leading to a high Faradaic efficiency of 46.4% at -0.1 V. The catalyst's electron charge distribution and surface oxygen vacancies play a crucial role in enabling selective NH3 production.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Greesh Kumar, Ramendra Sundar Dey
Summary: This study presents a simple and controllable chemical approach to synthesize dual transitional metals (cobalt, nickel) and nitrogen-doped carbon (CoNi-NC) as bifunctional electrode materials for rechargeable zinc-air batteries. The CoNi-NC material exhibits bifunctional electrocatalytic performance towards ORR/OER, with high half-wave potential, overpotential, and peak power density.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Greesh Kumar, Sabuj Kanti Das, Chandrani Nayak, Ramendra Sundar Dey
Summary: This study demonstrates a one-step approach to prepare a Pd catalyst with ultra-low loading. The pyrolysis of a porous organic polymer results in dispersed Pd nanoclusters and Pd single atoms doped into nanocarbon matrix in the catalyst. The catalyst shows remarkable bifunctional activity and durability toward oxygen reduction and evolution reactions, highlighting the significance of Pd-NC/Pd-NC800 as a bifunctional oxygen electrocatalyst.
Article
Chemistry, Multidisciplinary
Sakshi Bhardwaj, Sabuj Kanti Das, Ashmita Biswas, Samadhan Kapse, Ranjit Thapa, Ramendra Sundar Dey
Summary: In this study, a catalyst with hydrophobic and aerophilic characteristics was engineered by grafting fluorinated copper phthalocyanine (F-CuPc) with graphene, effectively suppressing the competitive hydrogen evolution reaction (HER) in the electrochemical nitrogen reduction reaction (eNRR). The chemically functionalized fluorine moieties in the second coordination sphere of the catalyst fostered N-2 diffusion and adsorption, while the active metal center in the primary sphere facilitated the NRR with a high faradaic efficiency (FE) of 49.3%. DFT calculations and in situ FTIR study supported the alternating pathway of the NRR process.
Article
Chemistry, Physical
Sakshi Bhardwaj, Samadhan Kapse, Soirik Dan, Ranjit Thapa, Ramendra Sundar Dey
Summary: This work focuses on the active sites of nitrogen-doped carbon-based electrocatalysts with 5-8-5 defect sites for the oxygen reduction reaction (ORR), and discovers their exemplary ORR activity. The defect-engineered graphene with optimized N-dopants and intrinsic (5-8-5) defects exhibits outstanding ORR performance, providing a strategy for synthesizing noble-metal-free high-performance electrocatalysts for energy conversion.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Chemistry, Physical
Greesh Kumar, Rajashi Haldar, Maheswaran Shanmugam, Ramendra Sundar Dey
Summary: In this study, a cobalt-imidazole-tetracarboxylate metal-organic framework (Co-MOF) was synthesized and further modified with graphene to develop a conducting electrocatalyst (Co-MOF/G) for the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER). The as-synthesized electrocatalysts exhibited good electrocatalytic performance and stability in alkaline media, and the mechanism of the electrocatalytic processes was revealed through experimental studies.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Chemistry, Inorganic & Nuclear
Sakshi Bhardwaj, Tribani Boruah, Ramendra Sundar Dey
Summary: Designing efficient bifunctional oxygen electrocatalysts is crucial for sustainable metal-air batteries and reversible fuel cells. In this study, a Fe-Co bimetal catalyst with a hierarchically porous 2D nanosheet structure was synthesized and exhibited remarkable activities for both oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) in an alkaline medium.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Physical
Greesh Kumar, Sabuj Kanti Das, Erakulan E. Siddharthan, Ashmita Biswas, Sakshi Bhardwaj, Manisha Das, Ranjit Thapa, Ramendra Sundar Dey
Summary: This study develops a catalyst (FePP@G(30/3/7)) by modifying a metal-porphyrin-pyrene-based π-conjugated porous polymer (FePP) with electrophoretically exfoliated graphene, which enhances the efficiency of the oxygen reduction reaction through the interface design via π-π interaction.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Chemistry, Multidisciplinary
Bharat Bhushan Upreti, Navpreet Kamboj, Ramendra Sundar Dey
Summary: Laser-irradiated graphene-based heterostructures have been studied for metal-free energy storage devices. Nitrogen-doped graphene (NG) prepared via laser irradiation on polyaniline-reduced graphene oxide (PANI-rGO) heterostructure shows excellent cycling stability and capacitance enhancement. The laser irradiation technique can be applied to fabricate NG-based microsupercapacitors (MSCs) with high charge storage capacitance and remarkable rate capability.
