Journal
CHEMISTRY-AN ASIAN JOURNAL
Volume 5, Issue 10, Pages 2258-2265Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201000315
Keywords
enantioselectivity; heterocycles; metathesis; ruthenium; synthesis design
Categories
Funding
- National Science Foundation of China [20872043]
- Academic Leaders in Wuhan Municipality [200851430486]
Ask authors/readers for more resources
The scope of the novel ruthenium-catalyzed tandem cross-metathesis/intramolecular-hydroarylation sequence is described. This methodology offers a practical and efficient synthesis of structurally diverse and complex tetrahydrocarbazoles in good to excellent yields (up to 98%). Moreover, preliminary efforts towards the development of an enantioselective version of the current process by sequential catalysis with ruthenium complex and chiral amine are presented, with high yields and enantioselectivities (up to 88% yield and 91% ee).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available