Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 24, Issue 53, Pages 14079-14083Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201803909
Keywords
C-H functionalization; Catellani reaction; flow chemistry; gas-liquid; homogeneous
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Funding
- Dutch Science Foundation (NWO) through an ECHO grant [713.013.001]
- VIDI grant [14150]
- COST (European Cooperation in Science and Technology) Action [CA15106]
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A practical homogeneous and gas-liquid palladium-catalyzed Catellani-type reaction using a continuous-flow platform is described. The implementation of continuous-flow technology allowed the acceleration of the transformation and, for the first time, expansion of the chemical space to gaseous olefins (i.e., ethylene, propylene and 3,3,3-trifluoropropene), thus providing a safe and practical approach to sterically hindered ortho-disubstituted styrenes and vinyl arenes. The complete control over the stoichiometry of gaseous reagents through flow technology proved essential for directing the selectivity of the Catellani reaction to the desired products.
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