Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 24, Issue 68, Pages 17915-17920Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201804663
Keywords
cluster compounds; cytotoxicity; hydrolysis; molybdenum; tungsten
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Funding
- Russian Science Foundation [15-15-10006]
- Grant of the President of Russian Federation [MK-180.2017.3]
- Russian Foundation for Basic Research [18-33-00209]
- EPSRC [EP/R006393/1]
- Royal Society [RSG\R1\180123]
- University of Hull
- EPSRC [EP/R006393/1] Funding Source: UKRI
- Russian Science Foundation [15-15-10006] Funding Source: Russian Science Foundation
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Octahedral molybdenum and tungsten clusters have potential biological applications in photodynamic therapy and bioimaging. However, poor solubility and hydrolysis stability of these compounds hinder their application. The first water-soluble photoluminescent octahedral tungsten cluster [{W6I8}(DMSO)(6)](NO3)(4) was synthesised and demonstrated to be at least one order of magnitude more stable towards hydrolysis than its molybdenum analogue. Biological studies of the compound on larynx carcinoma cells suggest that it has a significant photoinduced toxicity, while the dark toxicity increases with the increase of the degree of hydrolysis. The increase of the dark toxicity is associated with the in situ generation of nanoparticles that clog up the cisternae of rough endoplasmic reticulum.
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