Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 20, Issue 14, Pages 3932-3938Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201304923
Keywords
aerobic oxidative CN coupling; azoindazole; heterocycles; indazole; metal-free condition
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Funding
- 973 grant [2011CB965300]
- NSFC [21302106]
- Tsinghua University
- Tsinghua University Initiative Scientific Research Program
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A transition-metal-free oxidative CN coupling method has been developed for the synthesis of 1H-azaindazoles and 1H-indazoles from easily accessible hydrazones. The procedure uses TEMPO, a basic additive, and dioxygen gas as the terminal oxidant. This reaction demonstrates better reactivity, functional group tolerance, and broader scope than comparable metal catalyzed reactions.
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