Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 20, Issue 22, Pages 6678-6683Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201402187
Keywords
inorganic cells tissues; glyconano hybrids; molybdates; polyoxometalates; sugar-protein interactions
Categories
Funding
- Romanian National Authority for Scientific Research, CNCS-UEFISCDI grant [PN-II-ID-PCCE-2011-2-0028, 4/30.05.2012]
- Region Languedoc Roussillon (France)
Ask authors/readers for more resources
Herein, we consider Muller's spherical, porous, anionic, molybdenum oxide based capsule, (NH4)(42)- [{(Mo-VI)(Mo5O21)-O-VI(H2O)(6)}(12){(Mo2O4)-O-V(CH3COO)}(30)]10CH(3)COONH(4) 300H(2)O(NH4)(42)1acrystal ingredients1, {Mo-132}, as an effective sugar-decorated nanoplatform for multivalent lectin recognition. The ion-exchange of NH4+ ions of 1 with cationic-sugars, D-mannose-ammonium chloride (2) or D-glucose-ammonium chloride (3) results in the formation of glyconanocapsules (NH4)(42-n)2(n)1a and (NH4)(42-m)3(m)1a. The Mannose (NH4)(42-n)2(n)1a capsules bind selectively ConcanavalinA (ConA) in aqueous solution, giving an association avidity constant of =21.9, reminiscent of the formation of glycoside clusters on the external surface of glyconanocapsule. The glyconanocapsules (NH4)(42-n)2(n)1a and (NH4)(42-m)3(m)1a self-assemble in hybrid multilayers by successive layer-by-layer deposition of (NH4)(42-n)2(n)1a or (NH4)(42-m)3(m)1a and ConA. These architectures, reminiscent of versatile mimics of artificial tissues, can be easily prepared and quantified by using quartz crystal microgravimetry (QCM). The biomimetic hybrid multilayers described here are stable under a continual water flow and they may serve as artificial networks for a greater depth of understanding of various biological mechanisms, which can directly benefit the fields of chemical separations, sensors or storage-delivery devices.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available