Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 20, Issue 26, Pages 7987-7993Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201400138
Keywords
arginine; calixarene; click chemistry; nanochannel; sensor
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Funding
- National Nature Science Foundation of China [21372092, 21072072, 21102052]
- Program for New Century Excellent Talent in University [NCET-10-0428]
- CCNU from the colleges' basic research and operation of MOE [CCNU11C01002, CCNU13F005]
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Inspired from their biological counterparts, chemical modification of the interior surface of nanochannels with functional molecules may provide a highly efficient means to control ionic or molecular transport through nanochannels. Herein, we have designed and prepared a aldehyde calix[4] arene (C4AH), which was attached to the interior surface of a single nanochannel by using a click reaction, and that showed a high response for arginine (Arg). Furthermore, the nanofluidic sensing system has been challenged with complex matrices containing a high concentration of interfering sequences and serum. Based on this finding, we believe that the artificial nanochannel can be used for practical Arg-sensing devices, and be applied in a biological environment.
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