Review
Oncology
Bowen Liu, Chengbin Dong, Quan Chen, Zhenhua Fan, Yu Zhang, Yifan Wu, Ting Cui, Fuquan Liu
Summary: Circular RNA (circRNA) is a stable non-coding RNA that is widely studied. Abnormal expression of circRNA has been found in various cancers and is closely associated with cancer development. Circ_0007534, a specific circRNA, is highly expressed in multiple malignant tumors and is considered as a potential tumor marker and therapeutic target.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Peifang Song, Quisha Pan, Zhaohui Sun, Liwei Zou, Ling Yang
Summary: FAP-alpha is an enzyme associated with tumors, which is underexpressed in normal tissues but significantly increased in diseased states. This review provides an overview of the discovery and latest advances in FAP-alpha, including its structural characteristics, inhibitors, and detection methods.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Javier Freire, Pilar Garcia-Berbel, Belen Caramelo, Lucia Garcia-Berbel, Victor J. Ovejero, Nuria Cadenas, Ainara Azueta, Javier Gomez-Roman
Summary: This study demonstrates that COL11A1 immunostaining is an accurate predictive marker of tumor infiltration in small biopsies of breast, colon, bladder, and ovarian cancer.
Article
Medicine, Research & Experimental
Yang Li, Riyue Feng, Xiao Yu, Lei Li, Yuhao Liu, Ruixiang Zhang, Xiankai Chen, Yahui Zhao, Zhihua Liu
Summary: SLC35E2 promotes ESCC cell proliferation, and KLF4 acts as a transcriptional repressor by regulating the expression of SLC35E2 to affect the malignant characteristics of ESCC.
Article
Biochemistry & Molecular Biology
Dabin Choi, Wesuk Kang, Soyoon Park, Bomin Son, Taesun Park
Summary: For several decades, excessive glucocorticoids (GCs) have been known to inhibit collagen synthesis and accelerate skin aging, but the molecular mechanisms involved are not well understood. In this study, the researchers identified potential glucocorticoid receptor (GR) target genes that may contribute to the inhibition of collagen synthesis. They confirmed that dexamethasone, a synthetic GC, activates canonical GR signaling in dermal fibroblasts and identified six candidate genes involved in the GC-mediated inhibition of collagen synthesis. This study provides insights into the molecular mechanisms of GC-mediated skin aging and lays the foundation for further research on the biological characteristics of individual GR target genes.
Review
Biochemistry & Molecular Biology
Alex Tuffour, Anthony Adebayiga Kosiba, Yao Zhang, Frank Addai Peprah, Jie Gu, Haifeng Shi
Summary: The calcium-sensing receptor (CaSR) plays a dual role in cancer, enhancing proliferation in some types such as breast, lung, prostate, and kidney cancers at the primary site while suppressing colon cancer. CaSR activity not only increases cancer cell proliferation, migration, and suppression of apoptosis, but also promotes osteolytic activity and osteoblastic suppression, contributing to cancer metastasis to bone.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Review
Medicine, Research & Experimental
Meilan Zhang, Juan Xiao, Jiangrong Liu, Xue Bai, Xuemei Zeng, Zhiwei Zhang, Feng Liu
Summary: Calreticulin (CRT) is a multifunctional protein found in the endoplasmic reticulum (ER), and it plays a role in tumor formation and development, as well as the proliferation and migration of tumor cells. When malignant tumors occur, CRT is exposed on the surface of cancer cells undergoing immunogenic cell death (ICD), acting as an "eat me" signal that promotes dendritic cells to phagocytose the tumor cells and increases the sensitivity of tumors to anticancer immunotherapy. The expression of CRT is higher in tumor tissues compared to normal tissues and is associated with disease progression in various malignant tumors. This review extensively discusses the potential of CRT as a diagnostic marker and therapeutic target for cancer.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Review
Cell Biology
Yaning Shi, Neng Zhu, Yun Qiu, Junlan Tan, Feiying Wang, Li Qin, Aiguo Dai
Summary: RELMs are highly cysteine-rich proteins, including RELM alpha, RELM beta, Resistin, and RELM gamma, which exhibit significant differences in structure, distribution, and function. The expression of RELMs is regulated by various signaling molecules, such as IL-4, IL-13, and their receptors. RELMs proteins are involved in a wide range of physiological and pathological processes, and participate in the progression of numerous diseases. Meanwhile, RELMs can serve as biomarkers, risk predictors, and therapeutic targets for these diseases, providing novel targets or strategies for their treatment and prevention.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Rheumatology
Keishi Etori, Shigeru Tanaka, Jun Tamura, Koto Hattori, Shin-Ichiro Kagami, Junichi Nakamura, Seiji Ohtori, Hiroshi Nakajima
Summary: This study found that FGFR1 marks terminal effector Tph cells in patients with RA, suggesting its important role in the pathogenesis of RA.
Article
Biochemistry & Molecular Biology
Sajjad Ahmad, Taghreed N. Almanaa, Saifullah Khan, Salma Mohammed Aljahdali, Yasir Waheed, Mohammad Abdullah Aljasir, Wafa Abdullah I. Al-Megrin, Aamir Aziz, Muhammad Ateeq, Fazli Amin, Saeed Ullah Khattak, Samira Sanami
Summary: This study used computer-aided drug discovery methods to identify three promising compounds as potential therapeutic targets for FGFR3 in bladder cancer. Molecular dynamics simulations and energy analysis confirmed the binding stability of these compounds with FGFR3.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Oncology
Claudia Alexandra Dumitru, Eileen Brouwer, Tamina Stelzer, Salvatore Nocerino, Sebastian Rading, Ludwig Wilkens, Ibrahim Erol Sandalcioglu, Meliha Karsak
Summary: The study identified Tctex1 as an independent prognostic marker for overall survival in GBM patients, with high expression significantly associated with short overall survival and progression-free survival. Tctex1 promotes the aggressiveness and proliferation of GBM cells, indicating its potential as a therapeutic target in GBM.
Article
Chemistry, Analytical
Mihaela Puiu, Lucian-Gabriel Zamfir, George Madalin Danila, Francesco Papi, Cristina Nativi, Valentin Mirceski, Camelia Bala
Summary: A peptide molecular wire was used as a conductive support for ligand immobilization in biosensing assays, with the kinetic parameters of the electrode reaction estimated. The peptide wire mediated a two-step electron transfer from Methylene Blue (MB) to the gold surface, with potential for developing an electrochemical peptide-based biosensor.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Multidisciplinary Sciences
Alexander Damanakis, Isabell Wahler, Hans Fuchs, Heike Loeser, Wolfgang Schroeder, Thomas Zander, Seung-Hun Chon, Christiane Bruns, Alexander Quaas, Florian Gebauer
Summary: This study demonstrates for the first time the prognostic significance of ITGB1 expression in a large population of patients with esophageal adenocarcinoma (EAC). High expression of ITGB1 is associated with tumor aggressiveness and poor survival.
SCIENTIFIC REPORTS
(2022)
Review
Oncology
Kui Zang, Liangliang Hui, Min Wang, Ying Huang, Xingxing Zhu, Bin Yao
Summary: TIM-3 was identified as an independent adverse prognostic indicator for overall survival in various types of cancer. It plays a crucial role in tumor immune responses, supporting its potential as a promising target for cancer immunotherapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Shahnaz Saednia, Saeed Emami, Sajjad Molavipordanjani, Seyed Mohammad Abedi, Fereshteh Talebpour Amiri, Seyed Jalal Hosseinimehr
Summary: This study aimed to develop novel tracers for targeting and imaging overexpressed serotonin-7 receptors in U-87 MG glioma xenografted nude mice. The radiotracers Tc-99m-PHH and Tc-99m-MPHH showed promising affinity and uptake in the tumor tissue, with Tc-99m-MPHH demonstrating higher affinity to 5-HT7Rs.
MOLECULAR PHARMACEUTICS
(2021)
Editorial Material
Gastroenterology & Hepatology
Yugo Iwaya, Catherine Streutker, Norman Marcon
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2019)
Editorial Material
Gastroenterology & Hepatology
Yuichiro Mochizuki, Yugo Iwaya, Mai Iwaya, Yuko Hirota, Haruhiro Inoue
GASTROINTESTINAL ENDOSCOPY
(2019)
Meeting Abstract
Gastroenterology & Hepatology
Kazuya Sumi, Haruhiro Inoue, Yuto Shimamura, Yugo Iwaya, Hideomi Tomida, Mayo Tanabe, Yusuke Fujiyoshi, Haruo Ikeda, Manabu Onimaru
GASTROINTESTINAL ENDOSCOPY
(2019)
Article
Gastroenterology & Hepatology
Yugo Iwaya, Haruhiro Inoue, Enrique Rodriguez de Santiago, Mary Raina Angeli Abad, Yusuke Fujiyoshi, Akiko Ueno, Mayo Tanabe, Kazuya Sumi, Hideomi Tomida, Masaki Ominami, Haruo Ikeda, Manabu Onimaru, Yuto Shimamura
DIGESTIVE ENDOSCOPY
(2020)
Article
Gastroenterology & Hepatology
Kazuya Sumi, Haruhiro Inoue, Yasutoshi Kobayashi, Yugo Iwaya, Mary Raina Angeli Abad, Yusuke Fujiyoshi, Yuto Shimamura, Haruo Ikeda, Manabu Onimaru
Summary: Anti-reflux mucosectomy is an effective minimally invasive therapy for patients with PPI-refractory GERD, significantly improving symptom scores and allowing some patients to discontinue PPI. Although AET and DeMeester scores improved significantly post-ARMS, there was no significant improvement in proximal extent.
DIGESTIVE ENDOSCOPY
(2021)
Editorial Material
Gastroenterology & Hepatology
Satoko Kako, Yugo Iwaya, Tadanobu Nagaya, Takeji Umemura
Summary: A 79-year-old male presented with a two-day history of obstipation and vomiting. Abdominal CT showed small bowel obstruction with a 3.5 cm gallstone impacted in the mid-small bowel. Despite three days of nasogastric tube decompression, the obstruction did not improve, leading to the use of DBE-assisted EHL for stone removal.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Gastroenterology & Hepatology
Yuto Shimamura, Haruhiro Inoue, Enrique Rodriguez de Santiago, Mary Raina Angeli Abad, Yusuke Fujiyoshi, Akiko Toshimori, Mayo Tanabe, Kazuya Sumi, Yugo Iwaya, Haruo Ikeda, Manabu Onimaru
Summary: The Endoscopic Pressure Study Integrated System (EPSIS) is a new diagnostic tool for GERD that shows good accuracy in diagnosing the condition by assessing intragastric pressure waveform patterns. In this study, analysis of EPSIS parameters, specifically pressure difference and waveform gradient, demonstrated high diagnostic accuracy for abnormal acid reflux in patients with GERD symptoms.
DIGESTIVE ENDOSCOPY
(2021)
Article
Surgery
Yuto Shimamura, Yugo Iwaya, Ryosuke Kobayashi, Enrique Rodriguez de Santiago, Niroshan Muwanwella, Spiro Raftopoulos, Jeffrey D. Mosko, Gary R. May, Gabor Kandel, Paul Kortan, Norman Marcon, Christopher W. Teshima
Summary: The study identified predictors of failure to achieve complete eradication of neoplasia and complete eradication of intestinal metaplasia in patients with Barrett's esophagus related high-grade dysplasia and early esophageal adenocarcinoma. Long-segment Barrett's esophagus and other clinical variables were associated with failure to achieve complete eradication. Patients with these predictors should be considered for a more intensive endoscopic treatment approach at expert centers.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Gastroenterology & Hepatology
Yuto Shimamura, Haruhiro Inoue, Enrique Rodriguez de Santiago, Mary Raina Angeli Abad, Yusuke Fujiyoshi, Akiko Toshimori, Mayo Tanabe, Kazuya Sumi, Yugo Iwaya, Haruo Ikeda, Manabu Onimaru, Miki Kushima, Kenichi Goda
Summary: This study aimed to evaluate the diagnostic yield of the fourth-generation EC for esophageal squamous lesions, revealing acceptable diagnostic accuracy and reliability in both experts and non-experts, especially when diagnosing SCC lesions.
DIGESTIVE ENDOSCOPY
(2021)
Article
Cell Biology
Mai Iwaya, Hiroyuki Hayashi, Tomoyuki Nakajima, Kazuyuki Matsuda, Yasuhiro Kinugawa, Yosuke Tobe, Yoko Tateishi, Yugo Iwaya, Takeshi Uehara, Hiroyoshi Ota
Summary: CLDN18 expression in CACs is associated with lymph node metastasis, MUC5AC expression, and loss of special AT-rich sequence-binding protein 2 expression. CACs are more likely to express CLDN18 compared to CRCs, while only a small percentage of CACs are immunoreactive for HER2 with no differences identified in sporadic CRCs. These findings suggest potential candidates for targeted zolbetuximab therapy among certain CAC cases.
Article
Gastroenterology & Hepatology
Haruo Ikeda, Haruhiro Inoue, Mary Raina Angeli Abad, Yusuke Fujiyoshi, Yohei Nishikawa, Akiko Toshimori, Mayo Tanabe, Yuto Shimamura, Kazuya Sumi, Yugo Iwaya, Anastassios Manolakis, Manabu Onimaru
Summary: Congenital esophageal stenosis (CES) in adults is a rare disorder presenting as achalasia, particularly in the distal esophagus. This study identified salient features of CES in adults and demonstrated favorable short-term outcomes of peroral endoscopic myotomy (POEM) for CES patients.
ANNALS OF GASTROENTEROLOGY
(2021)
Meeting Abstract
Gastroenterology & Hepatology
Suqing Li, Natalia C. Calo, Ryosuke Kobayashi, Yugo Iwaya, Norman E. Marcon, Gary R. May, Jeffrey D. Mosko, Christopher W. Teshima
GASTROINTESTINAL ENDOSCOPY
(2020)
Article
Gastroenterology & Hepatology
Haruhiro Inoue, Mayo Tanabe, Enrique Rodriguez de Santiago, Mary Raina Angeli Abad, Yuto Shimamura, Yusuke Fujiyoshi, Akiko Ueno, Kazuya Sumi, Hideomi Tomida, Yugo Iwaya, Haruo Ikeda, Manabu Onimaru
ENDOSCOPY INTERNATIONAL OPEN
(2020)
Article
Gastroenterology & Hepatology
Yugo Iwaya, Yuto Shimamura, Jeffrey D. Mosko, Gabor Kandel, Paul P. Kortan, Gary R. May, Norman E. Marcon, Christopher W. Teshima
DIGESTIVE AND LIVER DISEASE
(2019)
Meeting Abstract
Gastroenterology & Hepatology
Hiroyuki Uehara, Taiji Akamatsu, Tomoaki Suga, Tadanobu Nagaya, Yugo Iwaya, Takuma Okamura, Akihiro Ito, Eiji Tanaka