Article
Polymer Science
Kiomars Zargoosh, Homeira Naghshineh, Roozbeh Soltani, Mohammad Dinari
Summary: This study focuses on developing a stable, reusable, and fast adsorbent for complete removal of cationic and anionic pollutants from industrial wastewaters, which shows high efficiency in removing model dye pollutants in a short period of time. The synthesized Daps-POP demonstrates successful removal of simulated dye pollutants in a short period of time and high reusability.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Alexander Schulz, Frank Wuerthner
Summary: This study demonstrated a significant fluorescence enhancement for a weakly fluorescent merocyanine dye by co facially stacking it with other dyes in heterofolda-trimer architectures. This enhancement was explained by the rigidification of the emitting chromophore in the foldamer architecture and the presence of a non forbidden lowest exciton state in H-coupled heteroaggregates, suggesting a promising strategy for improved fluorophores inspired by nature's green fluorescent protein (GFP).
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Gana Sanil, Maciej Krzeszewski, Wojciech Chaladaj, Witold Danikiewicz, Iryna Knysh, Lukasz Dobrzycki, Olga Staszewska-Krajewska, Michal K. Cyranski, Denis Jacquemin, Daniel T. Gryko
Summary: This study presents the tandem intramolecular hydroarylation of alkynes accompanied by a 1,2-aryl shift. By utilizing the unique electron-rich character of the 1,4-dihydropyrrolo[3,2-b]pyrrole scaffold, pi-expanded, centrosymmetric pyrrolo[3,2-b]pyrroles were synthesized by reacting alkynes at the already occupied positions 2 and 5. The reaction only proceeds in the presence of cationic gold catalyst and produces unknown compounds with six conjugated rings. These synthesized compounds have potential applications in the creation of new materials with various functionalities.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Fabien Ceugniet, Quentin Huaulme, Alexandra Sutter, Denis Jacquemin, Nicolas Leclerc, Gilles Ulrich
Summary: This article reports the synthesis and properties of heterosubstituted alpha beta-fused BODIPY fluorophores. The compounds were synthesized from 2,3,5,6-tetrahalo-BODIPY through sequential and selective Stille cross-coupling reactions, allowing the introduction of different substituents at specific positions on the BODIPY ring. The fully fused compounds showed a bathochromically shifted emission and a hyperchromic shift of the absorption maxima, with relatively high fluorescence quantum yields. Computational studies were conducted to gain a comprehensive understanding of the photophysical behavior of these dyes.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Mengyao Zhao, Jianbo Wang, Zuhai Lei, Lingfei Lu, Shangfeng Wang, Hongxin Zhang, Benhao Li, Fan Zhang
Summary: The newly developed pTAS sensors can achieve high sensitivity tumor pH monitoring within a wider response region, extending the pH detection range. Through dual-channel ratiometric bioimaging, the dynamic changes in tumor pH can be visualized in vivo.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Ming-Ho Liu, Zhe Zhang, Yu-Chi Yang, Yang-Hsiang Chan
Summary: This study presents semiconductor polymers with emission characteristics in the NIR-IIa window, which show potential for high-resolution, noninvasive brain imaging in live mice and offer a platform for future design of NIR-IIa or even NIR-IIb emitting Pdots.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Organic
Kilian Colas, Susanne Doloczki, Mauricio Posada Urrutia, Christine Dyrager
Summary: This minireview discusses the synthesis, structure-photophysical properties relationship, and bioimaging applications of fluorescent coumarins, xanthenes, BODIPYs, and cyanines. Advantages and disadvantages of the emissive units are also explored, along with general practical considerations when using fluorophores in a biological context.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Polymer Science
Yuhang Li, Yunhao Luan, Wanyi Liu, Cong Wang, Hui Cao, Pengtao Liu
Summary: This study reports an improved method to prepare cellulose nanofibrils/polyvinyl alcohol (CNF/PVA) porous composite hydrogel and utilize it to support metal nanoparticles in order to enhance the catalytic degradation of dyes. The hydrogel adsorbs silver ions on its surface and reduces them to silver nanoparticles using an in situ reduction method, leading to efficient discoloration of cationic dyes. The hydrogel exhibits fast recovery and reusability, and holds great potential in water resources protection and catalytic applications.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Yuta Kudoh, Emi Suzuki, Hikari Ochiai, Kakeru Ise, Yoshifumi Kimura, Mao Minoura, Haruyuki Nakano, Yoshihiro Matano
Summary: The properties of azaporphyrins can be modulated by changing the number of meso-nitrogen atoms. This study reports the synthesis of the first examples of 5,10,15,20-tetraaryl-5-azaporphyrinium (MTAMAP) salts. The inclusion of one meso-nitrogen atom significantly changes the properties of the porphyrin ring, making MTAMAP salts promising for the development of new fluorophores and photosensitizers.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Ayse Aktalay, Taukeer A. Khan, Mariano L. Bossi, Vladimir N. Belov, Stefan W. Hell
Summary: New photoactivatable fluorescent dyes with emission ranging from green to far red have been prepared and studied. The dyes were used to create photoactivatable probes for live-cell staining and were applied in various advanced microscopy techniques. The performance and applicability of these probes in terms of labeling efficiency and resolution were evaluated, demonstrating their potential for optical nanoscopy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Maciej Krzeszewski, Lukasz Dobrzycki, Andrzej L. Sobolewski, Michal K. Cyranski, Daniel T. Gryko
Summary: The synthesis of a bowl-shaped nitrogen-doped nanographene involves a concise strategy using multicomponent synthesis and sequential intramolecular direct arylation reactions with different reactivity of bonds, resulting in interesting properties in the final structure.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Florian Grimm, Jasmin Rehman, Stefan Stoldt, Taukeer A. Khan, Jan Gero Schlotel, Shamil Nizamov, Michael John, Vladimir N. Belov, Stefan W. Hell
Summary: In this study, new rhodamine dyes were successfully synthesized through a series of reactions, and conjugates of these dyes with small molecules were used for specific labeling of organelles and components of the cytoskeleton in living cells. These dyes were also combined with fluorescent probes such as 610CP and SiR, and applied in two-color STED microscopy.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Krzysztof Gorski, Tea Ostojic, Marzena Banasiewicz, Erik T. Ouellette, Luca Grisanti, Daniel T. Gryko
Summary: A heavy metal-free synthetic methodology for the one-step conversion of ketones into 4,5,6,7-tetrafluorobenzofurans (F(4)BFs) has been developed. It has favorable qualities such as the use of readily available substrates, broad scope, scalability, and good reaction yields. The synthesized benzofurans were previously inaccessible, and this methodology also enables the preparation of furo[2,3-b]pyrazines and difuro[2,3-c:3',2'-e]pyridazine, which have not been explored before.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Bohdan Andreiuk, Ilya O. Aparin, Andreas Reisch, Andrey S. Klymchenko
Summary: Bulky hydrophobic counterions can insulate ionic dyes against aggregation-caused quenching, allowing preparation of highly fluorescent dye-loaded nanoparticles. These hydrophobic anions control dye communication and enhance dye encapsulation, showing promise for preparing bright and non-toxic fluorescent nanomaterials.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Organic
Adam Golcs, Balint Arpad Adam, Panna Vezse, Peter Huszthy, Tunde Toth
Summary: Acridine derivatives were synthesized as potential multifunctionalizable fluorescent precursors of sensor molecules, indicators, or dyes with improved stability compared to unsubstituted analogs. The new compounds exhibited promising optochemical-based photochemical properties, including extremely large Stokes-shifts, and the effects of substituents at position 9 on fluorescence signaling were investigated.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Correction
Chemistry, Analytical
Beatriz Lozano-Torres, Alba Garcia-Fernandez, Marcia Dominguez, Felix Sancenon, Juan F. Blandez, Ramon Martinez-Manez
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Beatriz Lozano-Torres, Alba Garcia-Fernandez, Marcia Dominguez, Felix Sancenon, Juan F. Blandez, Ramon Martinez-Manez
Summary: In this study, a beta-galactosidase-activatable near-infrared (NIR) senoprobe called NBGal was developed for the detection of senescent cells using the FDA-approved Nile blue (NB) fluorophore. NBGal exhibited selective tracking of senescent cells in vitro and in vivo, making it a qualitative and minimally invasive probe for direct detection of senescent cells.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Antoni Llopis-Lorente, Bastiaan C. Buddingh', R. Martinez-Manez, Jan C. M. van Hest, Loai K. E. Abdelmohsen
Summary: This article demonstrates population behavior in microorganisms based on quorum sensing communication. Researchers utilized giant lipid vesicles loaded with sender-receiver machinery (enzymes and responsive biomolecules) to achieve quorum sensing behavior in an artificial cell population. The system allows for the examination of collective output based on cell density, fuel concentration, and proximity, which are important factors controlling natural quorum sensing behavior.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Marcia Dominguez, Kathleen Meyer, Felix Sancenon, Juan F. Blandez, Manuel Serrano, Ramon Martinez-Manez
Summary: Kidney damage can be monitored using different biomarkers in blood, urine or serum, and kidney failure leads to the overexpression of the alanine aminopeptidase (APN) enzyme in urine. In this study, a molecular probe (NB-ALA) based on the Nile Blue fluorophore (NB) was designed to detect APN enzyme in urine through simple fluorometric measurements.
CHEMICAL COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Amelia Ultimo, Mar Orzaez, Maria J. Santos-Martinez, Ramon Martinez-Manez, Maria D. Marcos, Felix Sancenon, Eduardo Ruiz-Hernandez
Summary: The abnormal expression of vascular endothelial growth factor (VEGF) in the retinal pigment epithelium (RPE) is the main cause of subretinal neovascularisation in wet age-related macular degeneration (AMD). Encapsulating anti-VEGF drugs in large pore mesoporous silica nanoparticles (LP-MSNs) provides a potential solution for the issues in current AMD treatment, by improving drug penetration, retention time, and sustained release. In this study, an innovative LP-MSN-based nanosystem, functionalized with polyethylenimine (PEI) chains, is developed for topical administration of anti-VEGF siRNA molecules to RPE cells, demonstrating successful VEGF silencing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Maria Ruiz-Rico, Felix Sancenon, Jose M. Barat
Summary: The limited solubility of chitosan at neutral and alkaline pH values restricts its use as a natural food preservative. However, its covalent immobilisation on inert supports can preserve its antimicrobial properties. Research shows that chitosan immobilisation through covalent urea bonding is the most suitable method, and chitosan-functionalised supports can effectively reduce microbial contamination in apple juice.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Alejandra Estepa-Fernandez, Alba Garcia-Fernandez, Araceli Lerida-Viso, Angela Morella-Aucejo, Juan Jose Esteve-Moreno, Juan F. Blandez, Maria Alfonso, Vicente Candela-Noguera, Gema Vivo-Llorca, Felix Sancenon-Galarza, Mar Orzaez, Ramon Martinez-Manez
Summary: The engineering of nanoparticle communication has gained attention, but communication between nanoparticles and living systems is still understudied. This study explores a strategy that involves nanoparticle-cell-nanoparticle communication through modifying the environment. The targeted therapy through stigmergy communication effectively inhibits tumor growth and reduces metastases in a mouse model of triple-negative breast cancer with minimal side effects.
Article
Pharmacology & Pharmacy
Alejandra Estepa-Fernandez, Alba Garcia-Fernandez, Araceli Lerida-Viso, Juan F. Blandez, Irene Galiana, Felix Sancenon-Galarza, Mar Orzaez, Ramon Martinez-Manez
Summary: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited treatment options. Inducing senescence and removing senescent cells (senolysis) has been explored as a method to limit tumor progression. In this study, a combination treatment using palbociclib and navitoclax was found to delay tumor growth and reduce metastasis in a mouse model of aggressive TNBC.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Chemistry, Analytical
Eva Garrido, Guillermo Hernandez-Siguenza, Estela Climent, M. Dolores Marcos, Knut Rurack, Pablo Gavina, Margarita Parra, Felix Sancenon, Vicente Marti-Centelles, Ramon Martinez-Manez
Summary: The use of gamma-hydroxybutyric acid (GHB) in drug-facilitated sexual assault has increased, leading to the need for rapid GHB detection methods. A portable strip-based lateral flow assay (LFA) using a smartphone for fluorescence readout was developed for GHB analysis. This method is based on a Cu2+ complex with a tetradentate ligand and the fluorescent dye coumarin 343, and can detect GHB at concentrations as low as 0.03 μM in MES buffer solution and 0.1 μM in soft drinks and alcoholic beverages in just 1 min.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Gugu Kubheka, Estela Climent, Charlie Tobias, Knut Rurack, John Mack, Tebello Nyokong
Summary: This study used azaBODIPY dyes doped into polystyrene particles as optical probes for the detection of high-risk HPV types. The particles were successfully attached with HPV DNA single strands, and demonstrated low detection limits and a narrow detection range for HPV11. The results suggest that these particles have the potential for multiplex assays and further study.
Review
Biochemistry & Molecular Biology
Cristina Rodriguez-Carrillo, Miriam Benitez, Jamal El Haskouri, Pedro Amoros, Jose V. Ros-Lis
Summary: Covalent organic frameworks (COFs) have attracted great interest as a new type of crystalline porous polymers, but their preparation requires long reaction times. Microwave-assisted synthesis (MAS) offers a promising strategy for accelerating the reaction rate of COFs. In this review, we compile recent studies and experiments on the synthesis of COFs using MAS as an energy source, including imine, triazine, and other 2D COFs. We also summarize the research progress on 3D COFs, providing an overview of the chemical structures, synthesis parameters, and applications of the monomers and COFs in each article.
Article
Chemistry, Analytical
Oscar Nieves, David Ortiz de Zarate, Elena Aznar, Isabel Caballos, Eva Garrido, Ramon Martinez-Manez, Fabian Dortu, Damien Bernier, Beatriz Mengual-Chulia, F. Xavier Lopez-Labrador, Jens J. Sloth, Katrin Loeschner, Lene Duedahl-Olesen, Natalia Prado, Martin Hervello, Armando Menendez, Rainer Gransee, Thomas Klotzbuecher, M. Clara Goncalves, Fahimeh Zare, Ana Fuentes Lopez, Isabel Fernandez Segovia, Jose M. Barat Baviera, Jaime Salcedo, Sara Recuero, Santiago Simon, Ana Fernandez Blanco, Sergio Peransi, Maribel Gomez-Gomez, Amadeu Griol
Summary: This paper presents a concept for a novel adaptable sensing solution developed under the PHOTONGATE project. The solution allows for quantification of multiple analytes, with high sensitivity and selectivity. It relies on biochemical and photonic technologies and has potential applications in health diagnosis and food safety sectors.
Article
Chemistry, Multidisciplinary
Miriam Benitez, Cristina Rodriguez-Carrillo, Sheila Sanchez-Artero, Jamal El Haskouri, Pedro Amoros, Jose Vicente Ros-Lis
Summary: This study presents an innovative method for the synthesis and functionalization of mesoporous silica material UVM-7. The scaled-up procedures enable rapid synthesis of substantial quantities of materials with reduced environmental impacts.
Article
Chemistry, Applied
Vicente Candela-Noguera, Maria Alfonso, Pedro Amoros, Elena Aznar, Maria Dolores Marcos, Ramon Martinez-Manez
Summary: This study comprehensively investigates the factors affecting the formation of MCM-41 type mesoporous silica nanoparticles (MSN). The hydrolysis and condensation rates are found to play a central role in nanoparticle formation, and disregarded parameters such as stirring strength and surfactant addition rate are shown to modulate nucleation and growth. Furthermore, the aging and evolution of MSN are studied through the analysis of silica framework consolidation over time, providing insights into obtaining reproducible, homogeneous, and tailored-made MCM-41 type MSN.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
