Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 18, Issue 30, Pages 9294-9299Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201201173
Keywords
core-shell; cancer; fluorescence; gold; multifunctional particles; photothermal conversion; tumor cells
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Funding
- National Basic Research Program of China [2010CB934700]
- National Natural Science Foundation of China [91022032, 21061160492, J1030412]
- International Science & Technology Cooperation Program of China [2010DFA41170]
- National Synchrotron Radiation Laboratory at the University of Science and Technology of China
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Multifunctional Ag@Au@ phenol formaldehyde resin (PFR) particles loaded with folic acids (FA) have been designed for killing tumor cells through photothermy conversion under the irradiation of near-infrared (NIR) light. Possessing the virtue of good fluorescence, low toxicity, and good targeting, the nanocomposite consists of an Ag core, an Au layer, a PFR shell, and folic acids on the PFR shell. The Ag@PFR coreshell structure can be prepared with a simple hydrothermal method after preheating. We then filled the PFR shell with a layer of Au by heating and modified the shell with polyelectrolyte to change its surface charge state. To capture tumor cells actively, FA molecules were attached onto the surface of the Ag@Au@PFR particles in the presence of 1-ethyl-3-(3-dimethly aminopropyl) carbodiimide (EDAC) and N-hydroxysuccinimide (NHS). Owing to the excellent property of Au NPs and Ag NPs as photothermal conversion agents, the Ag@Au@ PFR@FA particles can be utilized to kill tumor cells when exposed to NIR light.
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