Facing the gem-Dialkyl Effect in Enzyme Inhibitor Design: Preparation of Homocycloleucine-Based Azadipeptide Nitriles

New Cathepsin Inhibitors to Explore the Fluorophilic Properties of the S2 Pocket of Cathepsin B: Design, Synthesis, and Biological Evaluation

(2011) Santos Fustero et al.   CHEMISTRY-A EUROPEAN JOURNAL

“Click” synthesis of small molecule–peptide conjugates for organelle-specific delivery and inhibition of lysosomal cysteine proteases

(2010) Yuhui Loh et al.   CHEMICAL COMMUNICATIONS

Peptidomimetic Inhibitors of Cathepsin K

(2010) W. Cameron Black   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Development of Nitrile-Based Peptidic Inhibitors of Cysteine Cathepsins

(2010) Maxim Frizler et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Thorpe–Ingold effect in organosilicon chemistry

(2010) Tien-Yau Luh et al.   DALTON TRANSACTIONS

Structural Optimization of Azadipeptide Nitriles Strongly Increases Association Rates and Allows the Development of Selective Cathepsin Inhibitors

(2010) Maxim Frizler et al.   JOURNAL OF MEDICINAL CHEMISTRY

Glycopolypeptides via Living Polymerization of Glycosylated-l-lysineN-Carboxyanhydrides

(2010) Jessica R. Kramer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antimalarial activity of azadipeptide nitriles

(2009) Reik Löser et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The gem-disubstituent effect—a computational study that exposes the relevance of existing theoretical models

(2009) Rafik Karaman   TETRAHEDRON LETTERS

Azadipeptide Nitriles: Highly Potent and Proteolytically Stable Inhibitors of Papain-Like Cysteine Proteases

(2008) Reik Löser et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION