Article
Chemistry, Applied
Byungjun Kim, Sukwoo Lee, Sarah Yunmi Lee
Summary: In this study, a new method was reported to successfully promote the catalytic asymmetric Diels-Alder reactions using a chiral catalyst in conjunction with a chiral isothiourea catalyst or a Bronsted acid, resulting in the synthesis of densely functionalized cyclohexenes with multiple stereocenters.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Physical
Viktoria Kozma, Zsolt Szakonyi, Gyorgy Szollosi
Summary: This study reveals the structural effects of beta-amino acids on the asymmetric Michael additions, including the impact of substituent bulkiness on selectivity, the beneficial arrangement of functional groups in cis isomers, and the influence of nitrogen substituents on reaction rate and enantioselectivity.
Article
Chemistry, Multidisciplinary
Qing-Qing Hang, Shu-Fang Wu, Shuang Yang, Xue Wang, Zhen Zhong, Yu-Chen Zhang, Feng Shi
Summary: The catalytic atroposelective synthesis of axially chiral isochromenone-indoles has been achieved using homophthalic anhydride-based indole derivatives as a new platform molecule for dynamic kinetic resolution. A wide range of axially chiral isochromenone-indoles were synthesized in high yields and excellent enantioselectivities using chiral quaternary ammonium salt as a phase-transfer catalyst in the catalytic asymmetric sulfonylation reaction.
SCIENCE CHINA-CHEMISTRY
(2022)
Article
Chemistry, Applied
I-Ting Chen, Ren-You Guan, Jeng-Liang Han
Summary: In this study, a catalytic asymmetric vinylogous Mannich/annulation/acylation reaction was developed for the synthesis of chiral spiro-oxindole piperidine derivatives with polyaromatic scaffolds. The reaction provided the desired products in good yields and high enantioselectivity. DFT computational calculations were used to explain the mechanism and origin of the observed enantioselectivity and O-acetylated products.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Ke-Wei Chen, Zhi-Han Chen, Shuang Yang, Shu-Fang Wu, Yu-Chen Zhang, Feng Shi
Summary: A new strategy has been developed for the highly atroposelective synthesis of N-N axially chiral indole scaffolds and bispyrroles, which can be used as chiral organocatalysts and exhibit potent anticancer activity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Organic
Martina Sotolova, Martin Kamlar, Marek Remes, Pierre-Yves Geant, Ivana Cisarova, Martin Sticha, Jan Vesely
Summary: An organocatalytic asymmetric domino Michael/alpha-alkylation reaction has been developed for the synthesis of 1,2,3-trisubstituted cyclopentane carbaldehydes. The reaction, catalyzed by chiral secondary amines, exhibits high diastereo- and enantioselectivities.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Feng-Tao Sheng, Shuang Yang, Shu-Fang Wu, Yu-Chen Zhang, Feng Shi
Summary: A new strategy for the enantioselective synthesis of axially chiral 3,3'-bisindoles was developed by directly coupling two indole rings using the C3-umpolung reactivity of 2-indolylmethanols. The synthesized compounds can be further modified to create axially chiral 3,3'-bisindole-based organocatalysts for asymmetric catalysis.
CHINESE JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Applied
Achille Antenucci, Giovanni Ghigo, Davide Cassetta, Marco Alcibiade, Stefano Dughera
Summary: Chiral phosphoric acids (CPAs) and their salts have been widely used as privileged catalysts in asymmetric transformations. Previous efficient CPAs have relied on C-2 symmetry and axial chirality, with the only exception being TADDOL derivatives. In this study, we have designed and synthesized C-2 symmetric cycloglycerophosphates (cGPAs), which were applied in the addition of trimethylsilyl cyanide (TMSCN) to aldehydes and ketones. The corresponding cyanohydrins were obtained with yields between 77% and 99% and enantiomeric excesses between 84.2% and 99.5%, in 27 examples. A DFT computational model was also used to rationalize the reaction mechanism and stereochemical outcome.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Multidisciplinary
Giuseppe Zuccarello, Suzanne M. Batiste, Hyungdo Cho, Gregory C. Fu
Summary: Due to increasing interest in the pharmaceutical industry, the synthesis of chiral alpha-aminoboronic derivatives has become an important challenge. In this study, we demonstrate the enantioselective synthesis of these derivatives using a chiral copper catalyst generated from commercially available components. Mechanistic studies were also conducted to optimize the process and provide insights into the reaction mechanism.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Organic
Mateus L. Stivanin, Marcelo Duarte, Luiz Paulo M. O. Leao, Felipe A. Saito, Igor D. Jurberg
Summary: Two visible-light-mediated O-H insertion protocols involving oximes and aryldiazoacetates have been reported, leading to different products depending on the solvent used. One protocol involves direct O-H insertion in DCM, while the other incorporates the ring-opened form of THF into the product structure. These metal-free protocols are mild, tolerant to air and moisture, and have been demonstrated in the synthesis of an acaricide.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Martin Berger, Davide Carboni, Paolo Melchiorre
Summary: The study presents the first catalytic enantioselective conjugate addition of allyl groups to alpha, beta-unsaturated aldehydes, utilizing the visible-light-excitation of chiral iminium ions to activate allyl silanes toward the formation of allylic radicals. This radical mechanism overcomes issues seen in traditional conjugate allylation processes and selectively installs prenyl fragments at the beta-carbon of enals.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Organic
Vincenzo Battaglia, Sara Meninno, Alessandra Lattanzi
Summary: In this study, a novel and concise method for the synthesis of the commonly used antiplatelet drug Plavix was developed. Through careful optimization of reaction conditions, a high synthesis yield and selectivity were achieved.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Jun-Hao Zhang, Hui Xu, Xiaodong Tang, Yanfeng Dang, Fa-Guang Zhang, Jun-An Ma
Summary: In this study, the efficient and stereoselective hydrogenation of congested tetra-substituted cyclic beta-enamido phosphonates/phosphine oxides was achieved using a commercially available Rh-Josiphos system. This method enables the synthesis of chiral beta-amino phosphorus compounds with two vicinal stereocenters. The protocol is applicable to various ring systems and different phosphonate/phosphine oxide groups, and it has been successfully applied to the preparation of amino-phosphine ligands. The DFT mechanistic explorations suggest that the C=C migratory insertion into the Rh-III-H bond is the rate- and stereo-determining step, and the origins of stereoselectivity are regulated by dispersion interactions and steric repulsions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Applied
Luka Ciber, Sebastijan Ricko, Jure Gregorc, Franc Pozgan, Jurij Svete, Helena Brodnik, Bogdan Stefane, Uros Groselj
Summary: This study demonstrates that Arylidene-Delta(2)-pyrrolin-4-ones can undergo organocatalyzed annulation with malononitrile to form dihydropyrano[3,2-b]pyrroles. The enantiomeric excess of the products can be increased by trituration. The enantioselectivity depends on the nature of the substrate and the conformation of the catalyst, which is solvent-controlled. The reaction mechanism involves a Michael addition reaction step followed by 6-exo-dig annulation, and the rate determining step is the former, consistent with the proposed model.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Mariia Babkova, Rene Wilhelm
Summary: In this study, a series of new multifunctional organocatalysts were prepared and evaluated for the asymmetric aldol reaction of acetone and aromatic aldehydes. Several of the catalysts exhibited high catalytic activity and selectivity. The combination of camphor-based moiety and proline-based unit was found to be crucial for the performance of the catalysts.
Article
Environmental Sciences
Ying Zhou, Xiaoxia Lu, Bo Yu, Dan Wang, Cheng Zhao, Qiong Yang, Qi Zhang, Ying Tan, Xinyi Wang, Junyu Guo
Summary: This study compared the composition and levels of NEOs in soils of different land use types. The concentrations of NEOs varied among different land types, with the highest levels observed in greenhouse soils. The levels of NEOs in soils planted with different crops also varied greatly.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Correction
Biochemical Research Methods
Luyuan Qin, Xiaomin Zhang, Jianfeng Wu, Wenpeng Zhang, Xiaoxia Lu, Hao Sun, Jinsong Zhang, Lei Guo, Jianwei Xie
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Luyuan Qin, Xiaomin Zhang, Jianfeng Wu, Wenpeng Zhang, Xiaoxia Lu, Hao Sun, Jinsong Zhang, Lei Guo, Jianwei Xie
Summary: In this study, an internal standard surface-enhanced Raman spectroscopy (IS-SERS) quantification method was developed to determine the concentration of paraquat in mouse plasma and lung tissues. The results showed that paraquat had a high absorption rate and slow elimination rate in mice, and it tended to accumulate in target organs after entering the blood. The IS-SERS method demonstrated good practical applicability.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Organic
Jichao Zhang, Wei Xiong, Yongju Wen, Xuewen Fu, Xiaoxia Lu, Guolin Zhang, Chun Wang
Summary: The prenylation of phenolic substrates promoted by magnesium dicarboxylates was investigated in this study. It was found that substrates with electron-donating group(s) yielded better results than those with electron-withdrawing group(s). Different solvents, such as MeCN and DMF, influenced the conversion and regio-selectivity of the reaction. Mechanistic study showed that the nucleophilic addition/substitution of the phenolic substrate to the alkyl halide occurred in the presence of the magnesium dicarboxylates. The method was successfully applied in the total synthesis of icaritin with a total yield of 33%.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Health Care Sciences & Services
Qi Zhou, Qinyuan Li, Janne Estill, Qi Wang, Zijun Wang, Qianling Shi, Jingyi Zhang, Xiaobo Zhang, Joseph L. Mathew, Rosalind L. Smyth, Detty Nurdiati, Zhou Fu, Hongmei Xu, Xianlan Zheng, Xiaodong Zhao, Quan Lu, Hui Liu, Yangqin Xun, Weiguo Li, Shu Yang, Xixi Feng, Mengshu Wang, Junqiang Lei, Xiaoping Luo, Liqun Wu, Xiaoxia Lu, Myeong Soo Lee, Shunying Zhao, Edwin Shih-Yen Chan, Yuan Qian, Wenwei Tu, Xiaoyan Dong, Guobao Li, Ruiqiu Zhao, Zhihui He, Siya Zhao, Xiao Liu, Qiu Li, Kehu Yang, Zhengxiu Luo, Enmei Liu, Yaolong Chen
Summary: This article systematically explores the methodology, advantages, and challenges in the development of Rapid Advice Guidelines (RAG), using the development experience of RAG for children with COVID-19 as an example. The study found that RAG development requires a clear and transparent formulation process, often utilizing a significant amount of indirect and non-peer-reviewed evidence to support recommendations.
BMC MEDICAL RESEARCH METHODOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Hailong Shi, Jian Yang, Yao Cheng, Jinlian Yang, Xiaoxia Lu, Xiaofeng Ma
Summary: A method for glycosylation of protecting-group-free pyranoses with flavonoids to generate flavonoid O-glycosides has been reported. This methodology enables the synthesis of a wide range of natural 7-flavonoid O-glycosides and their derivatives with excellent yields and exclusive 1,2-trans-stereoselectivity regardless of the anomeric configuration of the pyranoses employed. Highly regioselective glycosylation among different types of hydroxyl groups on the glycosyl acceptors was also achieved.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Pediatrics
P. Q. Huang, H. Du, H. B. Chen, Y. Li, H. W. Chen, X. L. Lei, M. R. Zhang, X. X. Lu
Summary: This study investigated the clinical characteristics of severe HAdV-7 pneumonia combined with IPFIs and found that Aspergillus was the most common species in IPFIs. For children with severe HAdV-7 pneumonia who are younger, have a long course of disease, and have been admitted to the ICU, it is important to monitor for multi-system dysfunction and the reduction of lymphocyte counts to predict the occurrence of IPFIs.
PEDIATRICS AND NEONATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuan Lin, Kanjana Wongkrajang, Xiaofei Shen, Ping Wang, Zongyuan Zhou, Thipphawan Chuprajob, Nilubon Sornkaew, Na Yang, Lijuan Yang, Xiaoxia Lu, Ratchanaporn Chokchaisiri, Apichart Suksamrarn, Guolin Zhang, Fei Wang
Summary: This study identified a new diarylheptanoid, compound 28, as an agonist of alpha 7 nAchR-JAK2-STAT3 signaling pathway, which can potentially be developed as a valuable candidate for the treatment of sepsis. These findings also provide a new lead structure for the development of anti-inflammatory agents targeting alpha 7 nAchR-JAK2-STAT3 signaling.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Yongxing Deng, Xiaoxia Lu, Lei Li, Songlin Xu, Chunhe Miao, Beichen Zhang
Summary: This study investigates the dynamic compression behavior of micron-sized Al powders under various loading conditions. The results show that the temperature of the Al powder specimen continued to increase after loading, indicating interactions between particles. The study also found that particle melting and merging occurred under unconfined loading, while there was no melting under confined loading. Additionally, particle melting was observed after single-pulse loading, but not significant due to insufficient impact energy and small deformation.
Article
Chemistry, Medicinal
Ting Peng, Yujiao He, Tao Wang, Jialing Yu, Xiaofang Ma, Zongyuan Zhou, Yuwen Sheng, Lingyu Li, Huipan Peng, Sheng Li, Jiawei Zou, Yi Yuan, Yongyun Zhao, Hailong Shi, Fu Li, Wanli Liu, Kaifeng Hu, Xiaoxia Lu, Guolin Zhang, Fei Wang
Summary: MicroRNAs play a key role in hepatocellular carcinoma tumorigenesis. A small molecule called CIB-3b has been identified, which suppresses the growth and metastasis of HCC by modulating the expression of miRNAs and proteins in HCC cells. CIB-3b disrupts the interaction between TRBP and Dicer, leading to changes in miRNA activity and production.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Medicine, General & Internal
Guo-Dong Lin, Jie-Yi Wu, Xiao-Bo Peng, Xiao-Xia Lu, Zhong-Ying Liu, Zhi-Guo Pan, Ze-Wu Qiu, Jian-Guang Dong
Summary: Improper mixing of household disinfectants can cause chlorine poisoning, leading to damage to the respiratory system. Corticosteroids may be beneficial for severe cases with lung exudation, and early symptomatic supportive treatment is recommended.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Pediatrics
Rong-Meng Jiang, Yue-Jie Zheng, Lei Zhou, Lu-Zhao Feng, Lin Ma, Bao-Ping Xu, Hong-Mei Xu, Wei Liu, Zheng-De Xie, Ji-Kui Deng, Li-Juan Xiong, Wan-Jun Luo, Zhi-Sheng Liu, Sai-Nan Shu, Jian-She Wang, Yi Jiang, Yun-Xiao Shang, Miao Liu, Li-Wei Gao, Zhuang Wei, Guang-Hua Liu, Gang Liu, Wei Xiang, Yu-Xia Cui, Gen Lu, Min Lu, Xiao-Xia Lu, Run-Ming Jin, Yan Bai, Le-Ping Ye, Dong-Chi Zhao, A-Dong Shen, Xiang Ma, Qing-Hua Lu, Feng-Xia Xue, Jian-Bo Shao, Tian-You Wang, Zheng-Yan Zhao, Xing-Wang Li, Yong-Hong Yang, Kun-Ling Shen
Summary: Monkeypox is a zoonotic disease that has been prevalent in some countries in central and western Africa since 1970. Since May 2022, monkeypox cases have been reported in more than 96 non-endemic countries and regions worldwide, with over 58,200 human monkeypox cases and community transmission as of September 14, 2022. The discontinuation of smallpox vaccination in 1980 resulted in a lack of immunity to monkeypox, causing global concern. China currently has four monkeypox cases, including three in Taiwan province and one in Hong Kong city. Children are vulnerable to monkeypox and are at high risk for severe disease or complications.
WORLD JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Enmei Liu, Rosalind Louise Smyth, Qinyuan Li, Amir Qaseem, Ivan D. Florez, Joseph L. Mathew, Yasser Sami Amer, Janne Estill, Quan Lu, Zhou Fu, Xiaoxia Lu, Edwin Shih-Yen Chan, Juergen Schwarze, Gary Wing-Kin Wong, Toshio Fukuoka, Hyeong Sik Ahn, Myeong Soo Lee, Detty Nurdiati, Bin Cao, Wenwei Tu, Yuan Qian, Shunying Zhao, Xiaoyan Dong, Xiaoping Luo, Zhimin Chen, Guobao Li, Xiaobo Zhang, Xiaodong Zhao, Hongmei Xu, Feng Xu, Yuan Shi, Ruiqiu Zhao, Yao Zhao, Junqiang Lei, Xianlan Zheng, Mengshu Wang, Shu Yang, Xixi Feng, Liqun Wu, Zhihui He, Shihui Liu, Qi Wang, Yang Song, Zhengxiu Luo, Qi Zhou, Gordon Guyatt, Yaolong Chen, Qiu Li
Summary: This article presents a guideline for the management of COVID-19 in children, covering prognostic factors, pharmacological treatment, and respiratory support for severe cases. It also includes recommendations for breastfeeding, vaccination, and pediatric mental health management.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Letter
Emergency Medicine
Yan-qing Liu, Xiao-xia Lu, Kai-xun Hu, Xiao-bo Peng, Yun Jiang, Li-mei Han, Zhi-qiang Ma, Ming-fei Peng, Kun Wan, Xi-gang Zhang, Ze-wu Qiu
WORLD JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Infectious Diseases
Fang Li, Yuan-Yuan Li, Ming-Jin Liu, Li-Qun Fang, Natalie E. Dean, Gary W. K. Wong, Xiao-Bing Yang, Ira Longini, M. Elizabeth Halloran, Huai-Ji Wang, Pu-Lin Liu, Yan-Hui Pang, Ya-Qiong Yan, Su Liu, Wei Xia, Xiao-Xia Lu, Qi Liu, Yang Yang, Shun-Qing Xu
Summary: This retrospective cohort study examined household transmission of COVID-19 and asymptomatic SARS-CoV-2 infections. It found that older individuals were more susceptible to infection, while children and adolescents were more likely to infect others. Pre-symptomatic cases were more infectious, and asymptomatic cases were less likely to infect others.
LANCET INFECTIOUS DISEASES
(2021)
