Synthesis of Tri- or Tetrasubstituted Pyrimidine Derivatives through the [5+1] Annulation of Enamidines with either N,N-Dimethylformamide Dialkyl Acetals or Orthoesters and Their Application in a Ring Transformation of Pyrimidines to Pyrido[2,3-d]pyrimidi

Preparation and evaluation of trisubstituted pyrimidines as phosphatidylinositol 3-kinase inhibitors. 3-Hydroxyphenol analogues and bioisosteric replacements

(2010) Jonathan M. Large et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Variolins and Related Alkaloids

(2009) Scott R. Walker et al.   CHEMICAL REVIEWS

More Sustainable Approaches for the Synthesis of N-Based Heterocycles

(2009) Nuno R. Candeias et al.   CHEMICAL REVIEWS

Consecutive Three-Component Synthesis of Ynones by Decarbonylative Sonogashira Coupling

(2009) Eugen Merkul et al.   CHEMISTRY-A EUROPEAN JOURNAL

An Unprecedented Approach to the Single-Step Synthesis of 3,4-Fused Pyrimidin-2-one and Pyrimidin-2-thione Derivatives by a [3+2+1] Annulation

(2009) Toshiaki Sasada et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of 2-Substituted Pyrimido[5,4-b]indolizine Derivatives from Acetates of Baylis-Hillman Adducts

(2009) Chunhao Yang et al.   HETEROCYCLES

Comprehensive Survey of Chemical Libraries for Drug Discovery and Chemical Biology: 2008

(2009) Roland E. Dolle et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

One-pot synthesis ofN2-aminoprotected 6-substituted and cycloalka[d] 4-trifluoromethyl-2-acetylaminopyrimidines

(2009) Helio G. Bonacorso et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Pyrido[2,3-d]pyrimidin-5-ones: A Novel Class of Antiinflammatory Macrophage Colony-Stimulating Factor-1 Receptor Inhibitors†

(2009) Hui Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery and Structure−Activity Relationships of Trisubstituted Pyrimidines/Pyridines as Novel Calcium-Sensing Receptor Antagonists

(2009) Wu Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Flexible Synthesis of Pyrimidines with Chiral Monofluorinated and Difluoromethyl Side Chains

(2009) Pierre Bannwarth et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Densely Substituted Pyrimidine Derivatives

(2009) Omar K. Ahmad et al.   JOURNAL OF ORGANIC CHEMISTRY

Recent highlights in the synthesis of highly functionalized pyrimidines

(2009) Marco Radi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

An Unprecedented Approach to 4,5-Disubstituted Pyrimidine Derivatives by a ZnCl2-Catalyzed Three-Component Coupling Reaction

(2009) Toshiaki Sasada et al.   ORGANIC LETTERS

Efficient and Facile Three-Component Reaction for the Synthesis of 2-Amine-4,6-diarylpyrimidine Under Solvent-Free Conditions

(2009) Qiya Zhuang et al.   SYNTHETIC COMMUNICATIONS

A Polar Radical Pair Pathway To Assemble the Pyrimidinone Core of the HIV Integrase Inhibitor Raltegravir Potassium

(2008) Philip J. Pye et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design and synthesis of a pyrido[2,3-d]pyrimidin-5-one class of anti-inflammatory FMS inhibitors

(2008) Hui Huang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of novel 2,4,5-substituted pyrimidine derivatives for anticancer activity

(2008) Fuchun Xie et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

N-Metalated imines by reaction of 1,1-diethoxybut-2-ene with aromatic nitriles, as useful intermediates for the synthesis of substituted pyrimidines and cyclopentenones

(2008) Marco Blangetti et al.   CHEMICAL COMMUNICATIONS

New Strategies for the Synthesis of Pyrimidine Derivatives

(2008) Matthew D. Hill et al.   CHEMISTRY-A EUROPEAN JOURNAL

5-Alkyl-6-benzyl-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones, a Series of Anti-HIV-1 Agents of the Dihydro-alkoxy-benzyl-oxopyrimidine Family with Peculiar Structure−Activity Relationship Profile

(2008) Maxim B. Nawrozkij et al.   JOURNAL OF MEDICINAL CHEMISTRY

Me3SiCl-Promoted Three-Component Coupling Reaction of a Functionalized Enamine, an Acetal, and an Alkyne: An Unprecedented Approach to the Synthesis of Tetrasubstituted Pyridines via a [3 + 2 + 1] Intermolecular Cyclization

(2008) Toshiaki Sasada et al.   JOURNAL OF ORGANIC CHEMISTRY

Conjugate Addition of Amines to an α,β-Unsaturated Imine Derived from α-Aminophosphonate. Synthesis of γ-Amino-α-dehydroaminophosphonates

(2008) Javier Vicario et al.   JOURNAL OF ORGANIC CHEMISTRY

A Convenient Synthesis of 5- and 6-Substituted 2-Phenyl-3H-pyrimidin-4-ones

(2008) Nilo Zanatta et al.   SYNTHESIS-STUTTGART

A route to functionalized pyrimidines from carbohydrates via amine-driven dehydrative ring transformations

(2008) Lal Dhar S. Yadav et al.   TETRAHEDRON LETTERS

Observations on the use of microwave irradiation in azaheterocycle synthesis

(2008) Matthew D. Hill et al.   TETRAHEDRON LETTERS

A direct oxidative route for the synthesis of pyrimidines using heteropolyacids

(2008) Majid M. Heravi et al.   TETRAHEDRON LETTERS

One-Pot Four-Component Reaction for the Generation of Pyrazoles and Pyrimidines

(2007) Jeffrey Stonehouse et al.   SYNLETT