Article
Chemistry, Multidisciplinary
Nikki A. Tzioumis, Duncan A. Cullen, Katrina A. Jolliffe, Nicholas G. White
Summary: A simple biphenyl bis-amidinium compound (1.Cl-2) can selectively precipitate sulfate from water even at low concentrations. It shows complete selectivity against monovalent anions and high selectivity even against CO32- and HPO42-. It is highly effective in removing sulfate (>90%) from both seawater and highly acidic conditions relevant to mining waste-streams. X-ray crystallography reveals the structure of 1.SO4 with tightly packed, anhydrous arrangement where each sulfate anion receives eight hydrogen bonds from amidinium N-H hydrogen bond donors.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Whitney S. Y. Ong, Ke Ji, Vishaka Pathiranage, Caden Maydew, Kiheon Baek, Rhiza Lyne E. Villones, Gabriele Meloni, Alice R. Walker, Sheel C. Dodani
Summary: Detection of anions in complex aqueous media is a fundamental challenge that can be addressed by supramolecular chemistry, and biomolecular hosts such as proteins can be used as alternatives to synthetic hosts.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Applied
Juhua Leng, Guoxing Liu, Tianwei Cui, Shuqiang Mao, Puyang Dong, Wannian Liu, Xin-Qi Hao, Mao-Ping Song
Summary: Photoresponsive control-release supramolecular systems have been developed for drug delivery and ion transport, using stiff-stilbenes-based bis-urea as a molecular tweezer to achieve reversible photoisomerization and selective ion recognition and release. This novel system also functions as a photoinduced fluorescence switch, showing potential for optically controlled drug delivery, anion transport regulation, and advanced optical materials.
Article
Chemistry, Organic
Roy Lavendomme, Steven Moerkerke, Gaelle Mariaule, Ivan Jabin
Summary: In this study, the binding properties of a family of heterotritopic receptors based on bis-calix[6]arenes towards dicarboxylates were investigated. The receptors C3U and C3TU showed a unique ability to cooperatively complex a dicarboxylate anion, while the newly synthesized C6U exhibited poor binding properties. Molecular modeling indicated that the oxalate anion was stabilized by hydrogen bonding with the urea bridges of the receptor and propylammonium cations nested within the calixarene cavities.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Nico J. Overeem, Erhard van der Vries, Jurriaan Huskens
Summary: This review explores how influenza viruses navigate mucus and recognize host cells through multivalent interactions. The surface proteins of the influenza A virus facilitate specific binding to host cells, and the importance of these multivalent interactions in crossing mucus and entering host cells is discussed. Techniques to measure the avidity and receptor specificity of influenza viruses are also reviewed.
Editorial Material
Chemistry, Multidisciplinary
Paulina Hernandez-Pacheco, Gustavo A. Zelada-Guillen, Margarita Romero-Avila, Roberto Carlos Canas-Alonso, Marcos Flores-Alamo, Martha V. Escarcega-Bobadilla
Summary: We synthesized and characterized a new Cu-Salphen compound, which acted as a Lewis acid to host guest anions in two different forms: a) free molecule, and b) copolymerized with protective co-monomers. Higher amounts of Cu-Salphen resulted in larger and more homogeneous polymer sizes. The polymer size, along with other factors such as glass transitions, heat capacity, thermal degradation, and host-guest species distribution, explained significant enhancements in the host's binding site.
Article
Chemistry, Multidisciplinary
Paulina Hernandez-Pacheco, Gustavo A. Zelada-Guillen, Margarita Romero-Avila, Roberto Carlos Canas-Alonso, Marcos Flores-Alamo, Martha Escarcega-Bobadilla
Summary: In this study, the synthesis and crystallographic characterization of a new Cu-Salphen compound and its use as a Lewis acid against guest anions were described. It was found that higher contents of Cu-Salphen resulted in larger and more homogeneous polymer sizes. The growth of the host's binding site was explained by factors such as polymer size, glass transitions, heat capacity, thermal degradation, guest-saturation degrees, and host-guest species distribution profiles. Spectrofluorimetry measurements showed that Cu-Salphen had larger blue-shifted luminescence in the polymers compared to the non-polymerized counterpart, and enhanced fluorescence upon guest association. A cooperative incorporation of the guests into the internally protected binding site pockets in the random coil polymer conformations was proposed.
Article
Chemistry, Multidisciplinary
Maksym Matviyishyn, Agata Bialonska, Bartosz Szyszko
Summary: Crownphyrins are a class of hybrid macrocycles combining structural features of porphyrin and crown ethers. They possess the ability to bind neutral and ionic guests. The presence of dynamic covalent imine linkages connecting the dipyrrin segment with the ether chain enables unusual coordination behavior of crownphyrins.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Ruikai Cao, Robert B. Rossdeutcher, Yulong Zhong, Yi Shen, Daniel P. Miller, Thomas A. Sobiech, Xiangxiang Wu, Laura Sanchez Buitrago, Karishma Ramcharan, Mark I. Gutay, Miriam Frankenthal Figueira, Pia Luthra, Eva Zurek, Thomas Szyperski, Brian Button, Zhifeng Shao, Bing Gong
Summary: This study reports the synthesis of aromatic pentaamide macrocycles with convergent binding sites, which strongly bind anions, selectively transport chloride ions across membranes, and restore the function of cystic fibrosis cells.
Article
Chemistry, Multidisciplinary
Andreas Erichsen, Dennis Larsen, Sophie R. Beeren
Summary: The study demonstrates that high concentrations of kosmotropic anions can enhance the effects of added hydrophobic templates, while chaotropic anions can themselves act as templates, causing predictable and significant changes in the cyclodextrin composition due to weak, but specific, binding interactions with alpha-CD.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Organic
Johannes Karges, Seth M. Cohen
Summary: A new type of receptor molecule based on a tripodal tris(pyrrolamide) motif is presented in this study, which can bind to various anions with high affinity. The study demonstrates the ability to differentiate between enantiomeric anions through the preorganized cavity structure of the receptors.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Patryk Niedbala, Kajetan Dabrowa, Agnieszka Cholewiak-Janusz, Janusz Jurczak
Summary: This study presents the synthesis and anion binding studies of a family of homologous molecular receptors based on a DITIPIRAM platform. The host-guest system offers multiple NH hydrogen bond donors to anions, forming stable complexes with carboxylates and chloride anions even in competitive solvent mixtures. Receptors 5 and 6 containing electron-withdrawing F- and -CF3 para-substituents were found to be the most effective derivatives in the series.
Article
Multidisciplinary Sciences
Xiaoping Wang, Mao Quan, Huan Yao, Xin-Yu Pang, Hua Ke, Wei Jiang
Summary: The authors report a pair of water-soluble naphthotubes with a pH-responsive cavity for switchable bifunctional recognition in water. These hosts have a switchable cavity and can be used for the construction of smart self-assembly systems and water-soluble molecular machines.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Organic
Douglas H. Banning, Grace M. Kuhl, Madeline M. Howell, Darren W. Johnson
Summary: In this study, ChemFETs were used to evaluate the anion affinity of two different supramolecular scaffolds, showing that receptor modification can impact chemical selectivity. Slight changes in the steric bulk of the supramolecular scaffolds resulted in orders of magnitude differences in aqueous anion detection limits of ChemFET sensors.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Andrew. T. Turley, Magnus W. D. Hanson-Heine, Stephen. P. Argent, Yaoyang Hu, Thomas. A. Jones, Michael Fay, Simon Woodward
Summary: Large S-8-corona[n]arene macrocycles with alternating aryl and 1,4-C6F4 subunits were successfully synthesized on large scales using new high acceleration SNAr substitution protocols. The size and functionality of the macrocycles can be adjusted by selecting the appropriate precursor and catalyst. Furthermore, the inclusion of solvent controls the conformation and fluorine-fluorine interactions of the macrocycles, leading to spontaneous self-assembly into honeycomb-like lattices.
Article
Chemistry, Multidisciplinary
Robert A. Tromans, Tom S. Carter, Laurent Chabanne, Matthew P. Crump, Hongyu Li, Johnathan V. Matlock, Michael G. Orchard, Anthony P. Davis
Review
Chemistry, Multidisciplinary
Jinqiao Dong, Anthony P. Davis
Summary: Hydrogen bonding plays a key role in molecular recognition, and recent research has focused on utilizing it in water. Synthetic receptors combining hydrogen bonding with hydrophobic interactions show promise for biomedical applications in the future.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Javier Ramos-Soriano, Sergio J. Benitez-Benitez, Anthony P. Davis, M. Carmen Galan
Summary: The development of chemosensors to detect analytes in biologically relevant solutions is a challenging task. This study successfully synthesized a fluorescent receptor that can detect glucose in aqueous media and distinguish between closely related monosaccharides, highlighting the potential of VIE-type receptors for the quantitative determination of saccharides in biological samples.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Editorial Material
Chemistry, Multidisciplinary
Luis Martinez-Crespo, Sarah H. Hewitt, Nicola Alessandro De Simone, Vladimir Sindelar, Anthony P. Davis, Stephen Butler, Hennie Valkenier
Summary: The cover of this issue features the transport of bicarbonate anions across the lipid bilayer of a liposome, contrasting with the spontaneous diffusion of CO2.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Multidisciplinary Sciences
Jinqiao Dong, Lingmei Liu, Chunxia Tan, Qisong Xu, Jiachen Zhang, Zhiwei Qiao, Dandan Chu, Yan Liu, Qun Zhang, Jianwen Jiang, Yu Han, Anthony P. Davis, Yong Cui
Summary: Researchers showed that crystals composed of discrete supramolecular coordination complexes can be exfoliated by sonication to produce free-standing monolayers. These monolayers have complex chiral surfaces and good crystallinity, and the intermolecular interactions sustaining them are purely due to apolar interactions. This unique material exhibits enhanced selectivity towards carbohydrate recognition.
Article
Chemistry, Organic
Claire S. S. Webster, Federica Balduzzi, Anthony P. P. Davis
Summary: In this study, two water-soluble tricyclic Temple macrocycles were synthesized and evaluated as receptors for aromatic compounds in aqueous media. The results showed that these macrocycles exhibited good selectivity for methylated purine alkaloids and displayed significant changes in fluorescence. Additionally, a geometrically complementary guest was identified with strong binding ability.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Federica Balduzzi, Patrick Stewart, Soumen K. Samanta, Tiddo J. Mooibroek, Thomas Hoeg-Jensen, Kejia Shi, Bradley D. Smith, Anthony P. Davis
Summary: This study discovers a new macrocyclic host that exhibits exceptional affinity and selectivity towards squaraine dyes in water, forming stable complexes with near-infrared fluorescence. This macrocyclic host has the potential to be used as a supramolecular glue in biomedical techniques.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Organic
Alister J. Flint, Anthony P. Davis
Summary: This article provides an overview of vancomycin's structure and action, surveys past work on vancomycin mimicry, and makes the case for renewed effort in the future.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Ondrej Jurcek, Nonappa, Elina Kalenius, Pia Jurcek, Juha M. Linnanto, Rakesh Puttreddy, Hennie Valkenier, Nikolay Houbenov, Michal Babiak, Miroslav Peterek, Anthony P. Davis, Radek Marek, Kari Rissanen
Summary: Constructing structurally complex architectures using unique ligands is a challenge in metallosupramolecular chemistry, but a superchiral Pd3L6 complex can be obtained via supramolecular transmetalation reactions. These complexes can self-organize into hexagonal microparticles in aqueous media, potentially leading to the development of novel metal-organic functional materials made of natural, abundant, and relatively inexpensive steroidal compounds.
CELL REPORTS PHYSICAL SCIENCE
(2021)
Article
Materials Science, Multidisciplinary
Awais Siddique Saleemi, Muhammad Hafeez, Aqsa Munawar, Naeem Akhtar, Waseem Abbas, Muhammad Ehsan Mazhar, Zahid Shafiq, Anthony P. Davis, Shern-Long Lee
JOURNAL OF MATERIALS CHEMISTRY C
(2020)
Article
Chemistry, Multidisciplinary
Danny Van Eker, Soumen K. Samanta, Anthony P. Davis
CHEMICAL COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Victoria L. Heywood, Thomas P. J. Alford, Julius J. Roeleveld, Siebe J. Lekanne Deprez, Abraham Verhoofstad, Jarl Ivar van der Vlugt, Sergio R. Domingos, Melanie Schnell, Anthony P. Davis, Tiddo J. Mooibroek
Review
Chemistry, Multidisciplinary
Anthony P. Davis
CHEMICAL SOCIETY REVIEWS
(2020)
Article
Chemistry, Multidisciplinary
Robert A. Tromans, Soumen K. Samanta, Andy M. Chapman, Anthony P. Davis
Article
Chemistry, Multidisciplinary
Hongyu Li, Hennie Valkenier, Abigail G. Thorne, Christopher M. Dias, James A. Cooper, Marion Kieffer, Nathalie Busschaert, Philip A. Gale, David N. Sheppard, Anthony P. Davis