Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 14, Issue 21, Pages 6483-6489Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200800101
Keywords
guanidinium; hydrogen bonds; mass spectrometry; post-translational methylation; solvent effects
Categories
Ask authors/readers for more resources
Highly solvated methylated guanidinium ions ([Me(n)Guan(H2O)(m)](+); n=0-4 and 6; m=1-> 50), which model the various post-translationally methylated states of arginine, were generated in the electrospray ionization (ESI) source of an unmodified commercial tandem mass spectrometer. The dehydration processes of highly solvated [Me,Guan(H2O)(21)](+) ions were monitored by using energy-dependent ESI MS. These data, together with supporting calculations, provide a detailed picture of the interplay of methylation and hydration, and both the calculations and the experimental evidence suggest a specific structural basis for the observed effects. The ramifications for biochemical binding events that are controlled by the post-translational methylation of arginine to give dimethylarginines are discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available