Journal
CHEMISTRY OF NATURAL COMPOUNDS
Volume 49, Issue 5, Pages 910-913Publisher
SPRINGER
DOI: 10.1007/s10600-013-0775-x
Keywords
NW-G12; desertomycin A; antibacterial activities; Streptomyces alboflavus 313
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Funding
- Natural Science Foundation of China [31101468]
- National Key Science and Technology Research Foundation of China [2010CB126105]
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In our continuous investigation of metabolites of Streptomyces alboflavus 313, NW-G12 (1), a novel nonchlorinated analogue of NW-G01, was obtained as a trace constituent in the weak polarity part and a known desertomycin A (2) was also isolated from the fermentation broth in the strong polarity part. The structures of compounds 1 and 2 were established by comprehensive analysis of 1D and 2D NMR spectral data. Moreover, compounds 1 and 2 showed strong antibacterial activities against Bacillus cereus, Staphylococcus aureus, and Bacillus subtilis, with MICs of less than 10 mu g/mL, but both show no antibacterial activities against two gram-negative bacteria.
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