Journal
CHEMISTRY OF NATURAL COMPOUNDS
Volume 48, Issue 3, Pages 412-415Publisher
SPRINGER
DOI: 10.1007/s10600-012-0262-9
Keywords
rearranged diterpene; 2D NMR; sponge; cytotoxicty
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Chemical investigation of an Okinawan marine sponge resulted in the isolation of two new spongian-class diterpenes 1 and 2 together with two known compounds, chromodorolide B (3) and chromodorolide C (4). Compound 1, named chromodorolide D, is an example of a diterpenoid with a highly rearranged chromodorane carbon skeleton, while compound 2 retains the open side chains. The structures of the new compounds were elucidated on the basis of extensive spectroscopic analysis and chemical conversion. Compounds 1-4 exhibited significant cytotoxicity against NBT-T2 rat bladder epithelial cells.
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