Article
Nanoscience & Nanotechnology
Ximing Peng, Xin Liu, Yanqing Yang, Mingwei Yu, Zhiwei Sun, Xiangru Chen, Keqiang Hu, Jing Yang, Shaotang Xiong, Bin Wang, Liya Ma, Zhenxing Wang, Hanxiao Cheng, Chuchao Zhou
Summary: This study presents a novel method to incorporate graphene oxide (GO) into microgels for bone tissue engineering to promote biomimetic mineralization. The GO-GelMA-Ap microgels exhibited a porous, interconnected structure with uniformly coated surfaces in bone-like apatite. The 1 mg/mL GO-GelMA-Ap group showed comparable Ca/P ratio to natural bone tissue and enhanced proliferation of BMSCs in vitro as well as increased bone formation in vivo.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Engineering, Multidisciplinary
Ling Wang, Yawen Huang, Kailei Ding, Yixiang Lai, Ruiqi Mao, Fengxiong Luo, Boqing Zhang, Jiayi Zhu, Yujiang Fan, Changchun Zhou, Kefeng Wang, Xingdong Zhang
Summary: Enhanced biomimetic mineralization was achieved through polyphosphate modification of gelatin. The polyphosphorylation was shown to increase the saturation of in-situ mineralization, leading to improved mechanical properties and osteogenesis of the mineralized composite. Combining 3D printing, the scaffolds with enhanced mineralization and macro-controllable porous structure were prepared for better bone regeneration.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Engineering, Biomedical
Juhi Chakraborty, Julia Fernandez-Perez, Kenny A. van Kampen, Subhadeep Roy, Tim ten Brink, Carlos Mota, Sourabh Ghosh, Lorenzo Moroni
Summary: Engineering biomimetic cellular microenvironments has been a priority in regenerative medicine. This study presents a 3D bioprinting approach using GelMA and SF-G bioinks to fabricate arch-like constructs for cartilage regeneration. The SF-G constructs showed higher cell proliferation and superior collagen network and chondrogenesis compared to GelMA constructs. Protein-protein interaction and gene analysis validated the in vitro results, emphasizing the role of SF-G in regulating signaling pathways. The 3D bioprinted arch-like constructs have great potential for cartilage regeneration.
Article
Biotechnology & Applied Microbiology
Minghan Chi, Na Li, Junkui Cui, Sabrina Karlin, Nadja Rohr, Neha Sharma, Florian M. Thieringer
Summary: This study applied polydopamine coating and immobilized hydroxyapatite nanoparticles on the surface of 3D printed PLA scaffolds to enhance their bone regenerative properties. The functionalized PLA scaffold showed improved surface properties without compromising the physicochemical properties of the material.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Materials Science, Ceramics
Oriol Gavalda Diaz, Katharina Marquardt, Stephen Harris, Louise Gale, Luc Vandeperre, Eduardo Saiz, Finn Giuliani
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2020)
Article
Multidisciplinary Sciences
Tianzhu Zhou, Chao Wu, Yanlei Wang, Antoni P. Tomsia, Mingzhu Li, Eduardo Saiz, Shaoli Fang, Ray H. Baughman, Lei Jiang, Qunfeng Cheng
NATURE COMMUNICATIONS
(2020)
Article
Engineering, Manufacturing
Can Cao, Jingsong Peng, Xiumin Liang, Eduardo Saiz, Stephan E. Wolf, Hanoch Daniel Wagner, Lei Jiang, Qunfeng Cheng
Summary: By mimicking the unique structure of biogenic silk, the performance of aramid fibers was significantly improved through a coating of graphene nanosheets, resulting in enhanced tensile strength and electrical conductivity.
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
(2021)
Article
Engineering, Biomedical
Nouf Aldegaither, Giorgio Sernicola, Ataollah Mesgarnejad, Alain Karma, Daniel Balint, Jianglong Wang, Eduardo Saiz, Sandra J. Shefelbine, Alexandra E. Porter, Finn Giuliani
Summary: The hierarchical arrangement of collagen and mineral in bones generates toughening mechanisms at every length scale. This study quantifies intrinsic deformation and toughening at the fibrillar level and highlights the critical role of fibril orientation on crack deflection. The anisotropic nature of bone at the fibrillar level provides important insights for understanding fracture resistance and the development of new therapies.
ACTA BIOMATERIALIA
(2021)
Article
Polymer Science
Itxaso Azcune, Arrate Huegun, Alaitz Ruiz de Luzuriaga, Eduardo Saiz, Alaitz Rekondo
Summary: Aromatic disulfide-based vitrimers demonstrate elasticity-driven shape-memory and plastic reprocessability through the rearrangement of dynamic covalent crosslinks. The key temperatures for triggering phase transition and disulfide exchange reaction are highly sensitive to the molecular structure of the polymer. The relationship between structure, dynamics, and shape-changing properties was investigated through the synthesis of five networks with varying T-g values, molecular structures, and crosslink densities.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Materials Science, Multidisciplinary
Oriol Gavalda-Diaz, Jack Lyons, Siyang Wang, Max Emmanuel, Katharina Marquardt, Eduardo Saiz, Finn Giuliani
Summary: The study investigated the {0001} basal plane delamination dominating the crack-wake bridging in MAX phases, using small-scale fracture testing of Ti3SiC2. It was found that the fracture energy depends on small misorientations angles of the basal plane, leading to permanent deformation and formation of dislocations at each side of the crack. This study provides insights into the enhanced fracture energy values and potential sources of energy dissipation in basal plane delamination in MAX phases.
Article
Materials Science, Multidisciplinary
Robin M. G. De Meyere, Kay Song, Louise Gale, Stephen Harris, Ian M. Edmonds, Thomas J. Marrow, Eduardo Saiz, Finn Giuliani, David E. J. Armstrong, Oriol Gavalda-Diaz
Summary: This study introduces a novel trench push-out test for the evaluation of interfacial properties in long fiber ceramic matrix composites. Different fiber types coated with BN interphases showed varying mean interfacial shear stresses during fiber sliding. The micromechanical technique allowed for visualization of how defects in the interphase or fiber affected the variability of interfacial property measurement.
JOURNAL OF MATERIALS RESEARCH
(2021)
Article
Materials Science, Multidisciplinary
Oriol Gavalda-Diaz, Riccardo Manno, Antonio Melro, Giuliano Allegri, Stephen R. Hallett, Luc Vandeperre, Eduardo Saiz, Finn Giuliani
Summary: In this study, stable interfacial crack propagation in SiC/BN/SiC CMCs was achieved using in situ micromechanical testing in the scanning electron microscope. The critical energy release rate of the BN-fiber interface in Mode I and II was found to be lower than that of the fiber, explaining the generalized fiber debonding observed in the fracture of these CMCs. This work highlights possible routes for the optimization and modeling of the new generation of CMC interphases.
Article
Chemistry, Multidisciplinary
Can Cao, Zongkai Lin, Xiaochen Liu, Yanyan Jia, Eduardo Saiz, Stephan E. Wolf, Hanoch Daniel Wagner, Lei Jiang, Qunfeng Cheng
Summary: Coating Bombyx mori silks with a thin layer of reduced graphene oxide (rGO) has been shown to significantly increase their tensile strength and toughness. This bioinspired approach provides a universal and facile strategy for functionalizing natural fibers.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Chu Lun Alex Leung, Iuliia Elizarova, Mark Isaacs, Shashidhara Marathe, Eduardo Saiz, Peter D. Lee
Summary: The study introduced reduced graphene oxide as an additive in LPBF technology, enabling processing of low absorption SiO2 powder with improved absorption rate and reduced warpage and porosity in glass tracks.
APPLIED MATERIALS TODAY
(2021)
Article
Materials Science, Ceramics
Justine Delage, Eduardo Saiz, Nasrin Al Nasiri
Summary: Ceramic matrix composites have excellent thermo-mechanical properties but lack standardized methods for characterizing fracture toughness. This study investigates the fracture behavior of silicon carbide materials reinforced by SiC fibers, identifying the toughening mechanisms and evaluating the fracture parameters.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2022)
Article
Materials Science, Multidisciplinary
Qiaosong Cai, Sylvain Meille, Shitong Zhou, Florian Bouville, Iuliia Tirichenko, Eduardo Saiz
Summary: In this work, thermally reversible pastes are used to fabricate ceramic matrix (Al2O3) composites reinforced with continuous metallic fibers (steel). The approach involves micro-extrusion of ceramic-metal filaments to create dense and lightweight cellular structures, combining the stiffness and strength of ceramics with the fracture resistance and energy absorption capabilities of metals. The structures fabricated with these filaments exhibit higher compressive strengths and energy absorption capabilities compared to pure ceramics, offering new opportunities in additive manufacturing of multi-material parts and devices.
MATERIALS & DESIGN
(2023)
Article
Materials Science, Multidisciplinary
Shitong Zhou, Qiaosong Cai, Iuliia S. Tirichenko, Victoria Vilchez, Oriol Gavalda-Diaz, Florian Bouville, Eduardo Saiz
Summary: In this study, ceramics with continuous weak interlayers were successfully printed using a combination of direct ink writing and coextrusion of multi-material pastes. The introduction of weak interlayers can increase fracture resistance and direct crack propagation. This method demonstrates the potential of enhancing mechanical properties using multi-material inks.
Review
Polymer Science
Weijun Li, Qingwen Guan, Ming Li, Eduardo Saiz, Xu Hou
Summary: Nature endows many organisms with the ability to respond to stimuli and carry out their basic physiological activities. Inspired by these biological structures, biomimetic hydrogel actuators with controllability, fast response, and toughness have been developed. This review discusses the principles of enabling stimulus-responsive behavior in polymer materials, recent progress in implementing stimuli-response behavior in bioinspired hydrogel actuators, and the mechanism of mechanical toughening and its role in applications.
PROGRESS IN POLYMER SCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Ming Li, Chang Li, Bamber R. K. Blackman, Eduardo Saiz
Summary: Bio-inspired superwetting interfaces can facilitate rapid transfer of liquid mass or momentum, and have potential applications in water-energy collection and energy conversion.