Journal
CHEMISTRY LETTERS
Volume 43, Issue 6, Pages 746-754Publisher
CHEMICAL SOC JAPAN
DOI: 10.1246/cl.140223
Keywords
-
Categories
Funding
- Ministry of Education, Culture, Sports, Science and Technology (Japan)
- Asahi Glass Foundation (Japan)
- Grants-in-Aid for Scientific Research [26670002] Funding Source: KAKEN
Ask authors/readers for more resources
This review focuses on the dynamic kinetic resolution (DKR) of racemic allylic alcohols to produce allylic esters in high chemical and optical yields, which was achieved by combining hydrolase-catalyzed kinetic resolution and in situ racemization of the remaining less reactive enantiomers. Two classes of racemization catalysts, e.g., Ru complexes and oxovanadium compounds, are mainly discussed. Typical examples of DKR are shown along with their application in the concise syntheses of optically active compounds as valuable synthetic intermediates. The domino process integrating DKR with the active use of the installed acyl moiety for subsequent intramolecular cyclization is also discussed, which has great potential for the asymmetric syntheses of optically active fused cyclic molecules possessing multiple stereogenic centers.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available