Pd/C-catalyzed and Water-mediated Hiyama Cross-coupling Reaction Using an Electron-deficient Phosphine Ligand

The Pd/C-catalyzed Hiyama cross-coupling reaction between a variety of aryl halides and aryltriethoxysilanes was developed. Since only small amounts of the 10% Pd/C (0.5 mol %) and phosphine ligand (1.0 mol %) are required for efficient reaction, the protocol would be practical for the construction of biphenyl derivatives.