4.3 Article

Addition-type Oxidation of Silylalkene Using Ozone: An Efficient Approach for Acyloin and Its Derivatives

Journal

CHEMISTRY LETTERS
Volume 40, Issue 3, Pages 233-235

Publisher

CHEMICAL SOC JAPAN
DOI: 10.1246/cl.2011.233

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Funding

  1. MEXT, Japan [2105]
  2. MEXT [09C46622a]
  3. NEDO, Japan
  4. Grants-in-Aid for Scientific Research [22106535] Funding Source: KAKEN

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Acyloins are efficiently synthesized in three steps from alkynes via hydrosilylation followed by an addition-type ozone oxidation and hydrogenation. The key intermediate alpha-silylper-oxy ketone is convertible to not only acyloin but also O-silylated acyloin and diketone.

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