Article
Chemistry, Multidisciplinary
Worakrit Saiyasombat, Supavadee Kiatisevi
Summary: The new chemosensor BODIPY-OO showed high sensitivity towards Ag+ and Hg2+ ions in methanol media, and can distinguish Hg2+ from Ag+. It can be used as a practical fluorescent probe for monitoring the presence of Ag+ and Hg2+ ions.
Article
Chemistry, Multidisciplinary
Yasinalli Tamboli, Amit P. Pund, Jaydeo T. Kilbile, Arvind Y. Merwade
Summary: This article describes a short and simple method for the synthesis of 2 beta-(1,2,3-Triazol-1-yl) methyl-2 alpha-methyl-6,6-dihydropenicillin-3 alpha-carboxylic acid diphenylmethyl ester (7) on a multi-gram scale. The method avoids the use of hazardous sodium azide and extremely flammable/asphyxiant acetylene gas. By optimizing the direct substitution reaction using mercury (II) acetate and azobisisobutyronitrile, the key intermediate 1,2,3-triazole was efficiently recovered. The target compound tazobactam was obtained with high purity and overall yield of 49%.
Article
Biochemistry & Molecular Biology
Karen Zagorski, Tommy Stormberg, Mohtadin Hashemi, Anatoly B. Kolomeisky, Yuri L. Lyubchenko
Summary: The interplay between the mechanical properties of double-stranded and single-stranded DNA plays an important role in genetic processes. In this study, DNA nanorings were designed to investigate the stretching effect of double-stranded DNA on single-stranded DNA. The results showed that the stretching effect was consistent with theoretical estimates. Furthermore, time-lapse observations revealed dynamic behavior of the DNA rings, allowing for the formation of various morphologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Yuwei Hu, Yujie Ke, Itamar Willner
Summary: A cascaded DNA hydrogel governed by pH-configurable A-motif, i-motif, and T·A-T triplex configurations is presented. Different pH conditions dictate the formation and stability of the hydrogel through the protonation and deprotonation of adenine and cytosine residues. This study advances the development of smart hydrogels capable of adapting to various environmental conditions by introducing multiple pH-responsiveness.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Optics
Yifan Zhu, Qingfeng Ding, Lanyong Xiang, Jinfeng Zhang, Xinxing Li, Lin Jin, Shangguan Yang, Jiandong Sun, Hua Qin
Summary: To meet the demand for broadband and high-sensitivity terahertz detectors, a broadband terahertz detector built with antenna-coupled AlGaN/GaN HEMTs was designed. The detector exhibits a continuous response spectrum in the range of 0.2 to 2.0 THz at 298 K and 0.2 to 4.0 THz at 77 K when exposed to incoherent terahertz radiation. Sensitivity was characterized under coherent terahertz irradiation, with noise-equivalent power (NEP) ranging from 188 pW/Hz at 298 K to 19 pW/Hz at 77 K, achieved at different frequencies.
Article
Nanoscience & Nanotechnology
Leo Sala, Tomas Perecko, Oto Mestek, Dominik Pinkas, Tomas Homola, Jaroslav Kocisek
Summary: In this study, cisplatin was utilized as a therapeutic and cross-linking agent for DNA origami nanostructures. The loading of cisplatin molecules onto the nanostructures showed time dependence and gradual release. Structural distortions were observed when the number of loaded cisplatin molecules exceeded a certain threshold. Cisplatin-loaded DNA origami nanostructures exhibited significant cytotoxicity against cancer cells, making them a promising drug carrier.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Physical
Philipp Gotico, Thu-Trang Tran, Aurelie Baron, Boris Vauzeilles, Christophe Lefumeux, Minh-Huong Ha-Thi, Thomas Pino, Zakaria Halime, Annamaria Quaranta, Winfried Leibl, Ally Aukauloo
Summary: The catalyst pioneered by Lehn for the two-electron reduction of CO2 has unique features in selective transformation. A novel ruthenium photosensitizer and rhenium catalyst dyad showed efficient charge accumulation under photo-induced conditions, although second electron accumulation was not observed in the experiment.
Correction
Chemistry, Multidisciplinary
Jinjin Yin, Jiuchao Wang, Xiyue Yang, Tao Wu, Huashan Wang, Xiaoming Zhou
Summary: The study presents a novel method for sensitive detection of mercury ions in aqueous media using Poly(adenine)-mediated DNA-functionalized gold nanoparticles.
Review
Chemistry, Inorganic & Nuclear
Carolin Mueller, Sebastian Bold, Murielle Chavarot-Kerlidou, Benjamin Dietzek-Ivansic
Summary: In recent years, dyads in which molecular donor and acceptor moieties are chemically linked by a bridging ligand have shown promise in light-driven catalysis. The modular structure, control-lable donor-acceptor distance, and light-driven charge transfer abilities make these systems attractive for light-driven charge-transfer reactions and light-driven redox catalysis. This review discusses the role of 1,2,3-triazole bridging motif in driving electron transfer in triazole-bridged donor-acceptor dyads upon photoexcitation, and how the structural and electronic properties of the bridge influence charge separation and recombination rates. Criteria for designing dyads with different electron transfer properties are also derived.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Medicinal
Nonkululeko H. Zuma, Janine Aucamp, Helena D. Janse van Rensburg, David D. N'Da
Summary: Leishmaniasis is a parasitic disease transmitted through vectors, primarily affecting populations in tropical and sub-tropical countries. The lack of a protective vaccine and limited availability of clinical drugs with high toxicity hinder the eradication and elimination of this disease. Multidrug resistant strains of the causative pathogens have further increased the need for new and effective antileishmanial drugs. In this study, nitrofurantoin, a clinical antibiotic, was chemically linked to a triazole scaffold using alkylene linkers of varying lengths, and the resulting hybrids showed promising in vitro antileishmanial activity against two strains of Leishmania parasites. Hybrid 13, containing a n-pentylene linker, exhibited micromolar activity against antimonial-resistant L. donovani, the causative agent of deadly visceral Leishmaniasis.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biophysics
Ming-Yue Wang, Wen-Jie Jing, Li-Juan Wang, Li-Ping Jia, Rong-Na Ma, Wei Zhang, Lei Shang, Xiao-Jian Li, Qing-Wang Xue, Huai-Sheng Wang
Summary: A new electrochemiluminescence biosensor was developed for sensitive detection of miRNA-21 using a three-dimensional DNA nanomachine and duplex-specific nuclease (DSN)-mediated target recycle amplification strategy. The biosensor demonstrated excellent performance with a wide linear range and low detection limit, benefiting from the dual amplification strategy. This work provides a new approach for the application of DNA walkers in the construction of various biosensors.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Nanoscience & Nanotechnology
Jilai Jia, Xiaoping Du, Xuqin Lv, Fang Xie, Jiaojiao Zhou, Jie Cai
Summary: A DNA-mediated growth strategy was developed in this study for the synthesis of platinum nanoparticles (PtNPs) on the surface of graphene oxide (GO). The resulting GO-DNA-PtNPs exhibited excellent peroxidase-mimicking activity, and the activity could be inhibited by Hg(2+) due to the specific trapping of Hg2+ by thymine bases (T-Hg2+-T) and in situ reduction of Hg2+ by PtNPs on the GO surface. The sensor showed good linear range (from 1 pM to 1 μM) and a detection limit of 2.2 pM for Hg2+ analysis, demonstrating excellent analytical performance in complex lake waters.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Nidhi Nehra, Ram Kumar Tittal, Vikas D. Ghule, Nikhil Kumar, Avijit Kumar Paul, Kashmiri Lal, Ashwini Kumar
Summary: A series of benzothiazole linked 1,2,3-triazole hybrid molecules with varying alkyl spacers were efficiently synthesized under CuAAC conditions. Most synthesized compounds exhibited good DNA binding properties and drug-like characteristics, with some promising compounds showing good agreement with all experimental and theoretical computed properties.
Article
Environmental Sciences
Vahab Amiri, Peiyue Li, Prosun Bhattacharya, Mohammad Nakhaei
Summary: The study investigated the concentration of total dissolved mercury (Hg-T) in groundwater in the coastal parts of Urmia aquifer in Iran, identifying geological weathering as a main source of mercury. One sample exceeded the maximum contaminant level recommended by WHO. The distribution of water samples on the Piper diagram indicated Ca-Mg-HCO3 facies predominance, while the positive correlation of Hg-T with various elements suggested geological formations as a significant source of mercury. Water samples in Eh-pH regions showed potential microbial activity related to mercury methylation and mineralization, indicating sulfate reduction processes and limited anaerobic conditions. The study also found some Hg-bearing species in nonequilibrium geochemical conditions and speculated on the role of Fe-bearing minerals in reducing Hg(II) to Hg(0).
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Aida Iraji, Diba Shareghi-Brojeni, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Tahmineh Akbarzadeh, Mina Saeedi
Summary: A series of newly designed and synthesized cyanoacetohydrazide linked to 1,2,3-triazoles compounds were evaluated for their anti-alpha-glucosidase activity. Most of the synthesized compounds showed excellent inhibitory potential, with 9b and 9e exhibiting the highest activity. Kinetic binding studies and fluorescence measurements confirmed the interaction between these compounds and the enzyme.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Waka Nakanishi, Yoshihiro Yamauchi, Yuta Nishina, Masafumi Yoshio, Masayuki Takeuchi
Summary: This study analyzed the structures and properties of multilayered films prepared from graphene oxide (GO) subjected to different oxidation processes and found that their actuation ability in response to moisture varied. Despite similar size and physical properties, the difference in macroscopic hardness between the films influenced their moisture-induced actuation.
Article
Chemistry, Multidisciplinary
Koki Ikemoto, Misato Akiyoshi, Tatsuru Mio, Kaito Nishioka, Sota Sato, Hiroyuki Isobe
Summary: A saddle-shaped nanocarbon molecule with negative Gauss curvatures was synthesized successfully, and its structure and assembly were analyzed using spectroscopy, crystallography, and various theoretical methods. The study revealed the important role of molecular Gauss curvatures in the assembly process.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Jeff M. Van Raden, Dimitris Alexandropoulos, Michael Slota, Simen Sopp, Taisuke Matsuno, Amber L. Thompson, Hiroyuki Isobe, Harry L. Anderson, Lapo Bogani
Summary: Introducing paramagnetic metal centers into a conjugated pi-system is a promising approach for engineering spintronic materials. In this study, two types of spin-bearing dysprosium(III) and gadolinium(III) porphyrin dimers were investigated. The singly meso-meso-linked dimers are chiral, while the edge-fused tape complexes can be separated into syn and anti isomers.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Masaki Ishii, Taizo Mori, Waka Nakanishi, Jonathan P. Hill, Hideki Sakai, Katsuhiko Ariga
Summary: An air-water interface is used to control the molecular assemblies and conformations based on their intrinsic interactions and anisotropic stimuli. In this study, the researchers successfully controlled the molecular aggregated states and conformations at the interface by applying mechanical stimuli. The experiments showed that the molecular conformation and aggregated state can be changed by mechanical compression and vortex motions, providing a precise control over the molecular behavior.
Review
Multidisciplinary Sciences
Koki Ikemoto, Toshiya M. Fukunaga, Hiroyuki Isobe
Summary: By naming 1,3,5-trisubstituted benzene as phenine and designing the synthesis of curved nanocarbon molecules, heteroatoms and transition metals can be incorporated at specific positions. The development of tools to describe defects, quantify pyramidalizations, and estimate molecular Gauss curvatures has also been achieved. The investigations revealed the unique features of phenine nanocarbons.
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Misato Akiyoshi, Koki Ikemoto, Hioyuki Isobe
Summary: A method combining a data-driven empirical model with a traditional mechanistic model was developed to find the optimum synthetic conditions. The synthesis of a macrocycle with favorable features was achieved using this method.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Chemistry, Inorganic & Nuclear
Shigehisa Akine, Keisuke Nomura, Mizuho Takahashi, Yoko Sakata, Taizo Mori, Waka Nakanishi, Katsuhiko Ariga
Summary: The number of hydrophilic triethylene glycol (TEG) chains and the structure of the hydrophobic pi-extended metallosalen core were found to influence the formation behavior and flexibility of the amphiphilic complexes at the air-water interface.
DALTON TRANSACTIONS
(2023)
Correction
Chemistry, Multidisciplinary
Wei Fan, Taisuke Matsuno, Yi Han, Xuhui Wang, Qifeng Zhou, Hiroyuki Isobe, Jishan Wu
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Masatoshi Ito, Tomoko Fujino, Lei Zhang, So Yokomori, Toshiki Higashino, Rie Makiura, Kanokwan Jumtee Takeno, Taisuke Ozaki, Hatsumi Mori
Summary: Researchers synthesized planar alkoxy-substituted nickel bis(dithiolene) analogs with good solubility and crystallinity, which exhibited excellent ambipolar semiconductor performance in air. By addressing the molecular structure issue, they achieved high carrier mobility and large on/off ratio.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Hiroyuki Isobe, Yuki Kotani, Taisuke Matsuno, Toshiya M. Fukunaga, Koki Ikemoto
Summary: A molecular version of incommensurate double-wall carbon nanotubes was successfully designed by developing a roadmap for synthesizing cylindrical molecules with chiral indices. The atomic-level study of these unique systems revealed that different-sized molecules with helicity can be synthesized and assembled in a nonstereoselective manner.
COMMUNICATIONS CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Koki Ikemoto, Kanato Takahashi, Takeaki Ozawa, Hiroyuki Isobe
Summary: In this study, an information-theoretic approach called Akaike's information criterion is introduced to determine the stoichiometry of host-guest complexes. Several test cases with unique cylindrical hosts were examined to demonstrate the applicability of this method. Akaike's information criterion is proposed as a useful alternative to the Job plot for selecting the best model of host-guest complexes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Koki Ikemoto, Daiya Nagata, Taisuke Matsuno, Hiroyuki Isobe
Summary: Molecular hyperboloids with nanometer-sized structures and nanopores were successfully synthesized using oligomeric macrocyclization of [8]CMP molecule with two linkers. X-ray crystallographic analysis confirmed the structures of the obtained hyperboloids and revealed their resemblance to saddle-shaped phenine. This study suggests potential for exploring expanded networks of molecular hyperboloids.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Chemistry, Physical
W. Nakanishi, Y. Matsushita, M. Takeuchi, K. Sagisaka
Summary: The conformation and alignment of molecules in organic materials are important for their bulk physical properties. In this study, the conformation and alignment of a donor-acceptor-type molecule, IBN, are investigated in both 2D and 3D assemblies using STM and X-ray crystallography. The results show that IBN has a planar conformation in both assemblies and the dipole moment is cancelled out by molecular alignment. The orientation and self-assembled structure of IBN in 2D assemblies are affected by the surface density of IBN and the crystal orientation of Au(111).
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Multidisciplinary Sciences
Hiroyuki Isobe
Summary: The paper "On the Synthesis of Hinokitiol" published in this journal in 1950 marked the beginning of a new research field of novel aromatics.
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES
(2023)
Review
Multidisciplinary Sciences
Hiroyuki Isobe, Masahiro Hirama
Summary: By examining the seven papers published by Riko Majima in this journal and their surrounding contexts, we gain insight into the emergence of a community of scientists.
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES
(2023)
