Reductive Etherification under Microfluidic Conditions: Application to Practical Synthesis of the FGHIJ-Ring System of Yessotoxin

Reductive etherification, a key reaction for constructing the H-ring in the convergent synthesis of the FGHIJ-ring system of yessotoxin, was problematic because the yield dramatically decreased upon increasing the scale of the reaction. This issue was solved by the use of a microflow reactor, and a grain scale reaction was successfully performed.