Article
Biophysics
Fiona Gordon, Yannick Casamayou-Boucau, Alan G. Ryder
Summary: Studying the interaction between plasma proteins and liposomes is critical for drug delivery systems. This study explored the efficacy of ARMES for investigating the interaction of human serum albumin (HSA) with liposomes and compared it to conventional spectroscopic techniques. The findings provide useful information for understanding the interaction mechanisms.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Analytical
Amnah Yusaf, Muhammad Usman, Asim Mansha, Muhammad Siddiq, Zunaira Amjad, Saira Irshad, Hamadia Sultana
Summary: The focus of the reported work is on the solubility of Rhodamine B, exploring the use of mixed micellar media to facilitate the filtration of the solubilized dye for environmental safety. The results show that mixed micellar media has a higher solubilization capacity compared to individual surfactants.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2022)
Article
Engineering, Environmental
Tengyi Zhu, Yan Yu, Tianyun Tao
Summary: This study comprehensively evaluated 30 QSPR models for predicting Klip/w using the TOPSIS evaluation method based on entropy weight. The results revealed that RF method exhibited significant advantages in establishing the prediction model. The proposed evaluation method is hoped to be applied in more fields.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Biochemical Research Methods
Hui Jiang, Hao Zhang, Shi-Jun Yin, Min Lu, Xu Wang, Feng-Qing Yang
Summary: This study focused on profiling lipid-water partition coefficients of drugs using liposome electrokinetic chromatography (LEKC). Results showed that DSPC/Chol liposomes had a better linear relationship with the Caco-2 cell model compared to SPC/Chol liposomes, indicating their suitability for simulating cell membranes. The developed LEKC proved to be an effective model for measuring the log K-L/W of drugs.
Article
Biochemistry & Molecular Biology
Omolayo J. Olorunwa, Bikash Adhikari, Ainong Shi, T. Casey Barickman
Summary: This study analyzed the morpho-physiological responses of 30 cowpea genotypes to waterlogging, revealing that under waterlogging conditions, cowpea plant height, leaf area, and weight decreased while water use efficiency and adventitious roots increased. Chlorophyll fluorescence parameters were also affected. The study identified waterlogging-tolerant and sensitive cowpea genotypes, which could be useful for genetic engineering and breeding programs aimed at improving cowpea waterlogging tolerance.
Article
Geochemistry & Geophysics
Etsuo Uchida, Keiko Wakamatsu, Naoki Takamatsu
Summary: Under supercritical hydrothermal conditions, a simultaneous partition experiment of divalent metal ions between sphalerite and aqueous solution showed specific order of partition coefficients, with Ni exhibiting a positive partition anomaly possibly due to its large electronegativity. The optimal ionic radius for sphalerite was slightly larger than that of Zn, around 0.76 angstrom.
Article
Chemistry, Physical
Seyyed Mohammad Arzideh, Kamyar Movagharnejad, Mohsen Pirdashti
Summary: A novel quaternary aqueous biphasic system composed of 1-decyl-3-methylimidazolium chloride, 2-propanol, and dipotassium hydrogen phosphate was investigated for its partition behavior of L-tryptophan and vanillin at different mass ratios. The ion-association and solvation behavior of the ionic liquid in the solution were studied using electrical conductivity measurement and analyzed with the low-concentration chemical model. The hybrid ion-interaction and solvation model coupled with the UNIQUAC model provided insights into the ion-solvent interaction and partitioning of biomolecules, showing good agreement with experimental data.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Physical
V. Kathiravan, G. Satheesh Kumar, S. Pari, P. Selvarajan
Summary: This study investigated the structural, optical, mechanical, thermal, and electrical properties of Rhodamine-B doped L-histidine hydrofluoride dihydrate (RLHHF) crystals. The RLHHF crystals exhibited good optical transmittance and an increase in SHG efficiency with particle size. The results suggest promising applications for RLHHF crystals in various fields.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Analytical
Li Cui, Li Xu, Hongxia Yu, Qixiang Feng, Huijiao Yan, Shahid Aziz, Qixu Chen, Jibo Ren, Xingmin Gao, Daijie Wang
Summary: A fast and effective bilinear gradient counter-current chromatography method was proposed for the preparative isolation of ginsenosides from Panax quinquefolium L. roots. Eleven main ginsenosides were successfully separated with purities exceeding 95% using n-butanol and ethyl acetate as mobile phases. The method can be applied to isolate active compounds from other complex natural products.
JOURNAL OF SEPARATION SCIENCE
(2023)
Article
Biology
Hendry Susila, Snjezana Juric, Katarzyna Gawarecka, Kyung Sook Chung, Suhyun Jin, Soo-Jin Kim, Zeeshan Nasim, Geummin Youn, Ji Hoon Ahn
Summary: Protein-lipid interactions are crucial in many biological processes, but predicting and determining these interactions remain challenging. This protocol presents four in vitro experiments to determine the interaction between a protein and lipids, as well as evaluating the strength of the interaction.
Article
Agriculture, Multidisciplinary
Lourival C. Paraiba, Joana M. S. Ferreira, Vera L. Ferracini, Semiramis R. R. Ramos, Antonio L. Cerdeira, Marcia R. Assalin, Ricardo A. A. Pazianotto, Agnaldo J. Santos, Carolina C. M. Paraiba
Summary: The study presents a mathematical model to simulate the translocation of pesticides injected into coconut trees and evaluate pesticide residues in water and coconut pulp. The simulations showed that some pesticides have good translocation potential in coconut trees. No pesticide residues were found in the samples.
SPANISH JOURNAL OF AGRICULTURAL RESEARCH
(2022)
Article
Agronomy
Shuangya Wen, Nan Shi, Junwei Lu, Qianwen Gao, Huibing Yang, Zhiqiang Gao
Summary: This study proposes a method for fast and non-destructive monitoring of Fv/Fm by measuring hyperspectral reflectance information and Fv/Fm data of rice leaves during the whole growth period. The results show that spectral transformation methods such as first derivative transform, multiplicative scatter correction, and standardized normal variation can effectively highlight the correlation between spectral data and Fv/Fm. The CC-CARS algorithm effectively screens characteristic wavelengths sensitive to Fv/Fm and the BPNN models based on these wavelengths have high prediction accuracy.
Review
Chemistry, Applied
Stephen M. Burkinshaw
Summary: This review examines the promotional effect of added inorganic electrolyte on dye uptake during exhaust dyeing processes, considering the physico-chemical properties of different dye classes and their application fundamentals.
COLORATION TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Andreia Almeida, Eduarda Fernandes, Bruno Sarmento, Marlene Lucio
Summary: Camptothecin (CPT) is a potent anticancer drug with limited selectivity to its target. It binds strongly to plasma proteins, leaving a small percentage of free drug available for distribution to tissues. The drug's tendency to bioaccumulate in off-target tissues and its large distribution highlight the need for drug delivery systems to improve biodistribution.
Review
Biotechnology & Applied Microbiology
Pemula Gowtham, Pragya Pallavi, Karthick Harini, Koyeli Girigoswami, Agnishwar Girigoswami
Summary: Hydrogels, consisting of water-absorbing hydrophilic polymers, are a three-dimensional network that can support tissue regeneration and release medication in a controlled manner. They are structurally similar to the extracellular matrix and have been widely used in biomedical applications and tissue engineering. Incorporating plant virus-mediated nanoparticles (VNPs) into hydrogels is a promising approach to create bioactive scaffolds that promote cell proliferation, adhesion, migration, and differentiation.
CURRENT NANOSCIENCE
(2023)
Article
Materials Science, Biomaterials
Govindharaj Poornima, Karthick Harini, Pragya Pallavi, Pemula Gowtham, Koyeli Girigoswami, Agnishwar Girigoswami
Summary: Significant progress has been made in using biomaterials as a medium for delivering pharmacologically active components to diseased cells in biomedical sciences. The therapeutic benefit is more related to drug formulation and administration routes than drug potency. Biomaterials play a vital role in formulating various pharmaceutical compounds and extending therapeutic release to overcome limitations of conventional therapies. This review discusses the history of biomaterials in drug delivery and the use of RNA as a therapeutic molecule to inhibit disease-causing protein synthesis resulting from misregulation.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2023)
Article
Pharmacology & Pharmacy
Nagaraj Saraswathi, Koyeli Girigoswami, Kurunchi Chellapathi Divya, Subbaraj Gowtham Kumar, Agnishwar Girigoswami
Summary: Overuse and improper dosage of antibiotics have led to antimicrobial resistance worldwide. Silver nanoparticles have been identified as a promising option to overcome the infectious effect of multidrug-resistant organisms. Therefore, this study focuses on the development of gelatin-based polymeric hydrogel embedded with silver nanoparticles (G-AgNPs) for controlled bactericidal activity against multidrug-resistant Pseudomonas aeruginosa (PA) biofilms.
CURRENT DRUG DELIVERY
(2023)
Article
Nutrition & Dietetics
Gopikrishna Agraharam, Agnishwar Girigoswami, Koyeli Girigoswami
Summary: Oxidative stress is generated by endogenous cellular mechanisms and external factors, contributing to various disease pathologies. Chronic/acute exposure to oxidative stress can damage cellular integrity and lead to organ malfunctioning during aging. Mitochondrial respiration generates reactive oxygen species and free-radicals, which can cause damage to cellular organelles and biomolecules. Calorie restriction and extracellular ATP treatment, combined with advanced nanotechnology, can improve cellular integrity and enhance longevity by circumventing the mitochondrial pathway and alleviating oxidative stress.
CURRENT NUTRITION & FOOD SCIENCE
(2023)
Review
Nutrition & Dietetics
Sakthi Devi Rajendraprasad, Agnishwar Girigoswami, Swati Chakraborty, Koyeli Girigoswami
Summary: The ingestion of food contaminated with microorganisms can lead to serious foodborne diseases, making it crucial to detect toxins and identify pathogenic microbes accurately and sensitively. Natural toxins, chemical toxins, and metal toxins are the three major types of toxins. By utilizing nanomaterials, researchers have developed biosensors with improved sensitivity, stability, and specificity. Gold, silver, carbon nanotubes, graphene, magnetic nanoparticles, and quantum dots are commonly used nanomaterials in biosensor development. This mini-review provides an overview of both conventional and new analytical methods for detecting natural toxins in different food samples.
CURRENT NUTRITION & FOOD SCIENCE
(2023)
Review
Medicine, Research & Experimental
Pemula Gowtham, Koyeli Girigoswami, Pragya Pallavi, Agnishwar Girigoswami
Summary: In recent years, nanotechnology has been widely used in various medical fields, including the treatment of neurological disorders such as migraines. The interaction between nanomaterials and immune system components is of interest for treatment options. This review focuses on the advances in understanding the genetic factors associated with migraines and explores the potential applications of nanomedicine for their treatment and prevention.
BIOMEDICAL RESEARCH AND THERAPY
(2023)
Proceedings Paper
Polymer Science
Akash Sil, Madhumita Mukhopadhyay, Debosreeta Bose
Summary: The specific objective of this theoretical study is to explore the excited state intramolecular proton transfer property of 2-hydroxy-3-naphthaldehyde thiosemicarbazone (2H3NS). The study utilizes density functional theoretical (DFT) approach to determine the proper geometrical optimization of the molecule, determination of the intramolecular bond distance of OH during the transition state between the enolic and tautomeric forms, and simulating potential energy curves (PECs) at both the ground and excited states. The findings are further corroborated by FTIR spectroscopy through the formation of both OH and NH bond in the transition state.
MACROMOLECULAR SYMPOSIA
(2023)
Article
Chemistry, Analytical
Debanjana Ghosh, Austin Atkinson, Jaclyn Gibson, Harini Subbaiahgari, Weihua Ming, Clifford Padgett, Karelle S. Aiken, Shainaz M. Landge
Summary: A 1,2,3-triazole-based chemosensor shows selective switching in logic gate operations through colorimetric and fluorometric responses. It becomes fluorescent when sensing fluoride, but turns off fluorescence when metal ions, such as Cu2+ and Zn2+, are added. Nuclear Magnetic Resonance (NMR) spectroscopy and UV-Vis absorption and fluorescence profiles confirm the photophysical characteristics. This sensor exemplifies the Write-Read-Erase-Read mimic.
Article
Materials Science, Multidisciplinary
Devadass Jessy Mercy, Karthick Harini, Swaminathan Madhumitha, Chinnadurai Anitha, Jayakumar Iswariya, Koyeli Girigoswami, Agnishwar Girigoswami
Summary: Responsive polymeric nanostructures are being designed to deliver therapeutics in specific locations, improving treatment efficiency and acting as probes for imaging applications. The pH variability in tumors has led to interest in designing pH-responsive polymers. These polymers release the cargo sealed inside the carrier upon encountering a pH drop. The synthesis and fabrication of pH-responsive theranostic agents can overcome limitations of conventional treatments, particularly in cancer.
JOURNAL OF METALS MATERIALS AND MINERALS
(2023)
Review
Chemistry, Medicinal
Pragya Pallavi, Karthick Harini, Noureddine Elboughdiri, Pemula Gowtham, Koyeli Girigoswami, Agnishwar Girigoswami
Summary: The COVID-19 pandemic has highlighted the need for managing infectious diseases. Scientists are investigating photodynamic therapy (PDT) as a potential treatment for COVID-19. This therapy uses nanoparticles to interact with the virus and destroy microorganisms by activating photosensitizers with specific light in the presence of oxygen.
Review
Chemistry, Medicinal
Gopalarethinam Janani, Agnishwar Girigoswami, Koyeli Girigoswami
Summary: Chronic myelogenous leukemia (CML) is caused by the reciprocal translocation of the ABL gene and the BCR gene, and nanotechnology holds great potential in diagnosing and treating CML.
Review
Green & Sustainable Science & Technology
Sanmitro Bhattacharjee, Agnishwar Girigoswami, Moupriya Nag, Tanzil Rubab, Koyeli Girigoswami
Summary: This article focuses on the application of nanotechnology in sustainable development, particularly in the industrial field, to address environmental crises and protect ecological health.
ENVIRONMENTAL QUALITY MANAGEMENT
(2023)
Review
Agronomy
Karthick Harini, Koyeli Girigoswami, Pragya Pallavi, Anbazhagan Thirumalai, Pemula Gowtham, Agnishwar Girigoswami
Summary: Due to population growth and development of agricultural land, there is a high demand for agricultural goods and an overuse of pesticides, which may pose health risks. Alternative technologies, such as nanotechnology, are needed for pesticide detection and residual analysis.
JOURNAL OF PLANT PROTECTION RESEARCH
(2023)
Article
Engineering, Biomedical
A. Harini, Sharon P. S. Sofini, Deepika Balasubramanian, Agnishwar Girigoswami, Koyeli Girigoswami
Summary: Nanocomposites, including natural and synthetic polymer nanocomposites, have emerged as important biomaterials with prominent medical applications. These materials possess high stability, non-immunogenicity, sustained drug delivery, and can be widely used in medical implants, wound healing, and bone repair.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Review
Pharmacology & Pharmacy
Koyeli Girigoswami, Pragya Pallavi, Agnishwar Girigoswami
Summary: Site-specific drug delivery can reduce side effects and dosage requirements. Nanoparticles are effective drug carriers that can achieve precise delivery through passive or active targeting.
Article
Biochemistry & Molecular Biology
Raja Narayanasamy, Dandamudi Usharani, Ram Rajasekharan
Summary: This study investigated the role of ABHD16B in lipid metabolism. The overexpression of ABHD16B was found to decrease cellular triacylglycerol levels and increase phospholipid synthesis in yeast cells. Additionally, ABHD16B overexpression led to a reduction in lipid droplets and significant modifications in fatty acid composition. These findings highlight the importance of ABHD16B in lipid homeostasis and provide insights into its regulatory function in cellular lipid metabolism.
CHEMISTRY AND PHYSICS OF LIPIDS
(2024)
