Journal
CHEMISTRY AND PHYSICS OF LIPIDS
Volume 159, Issue 1, Pages 38-44Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.chemphyslip.2009.01.005
Keywords
BODIPY-labelled gangliosides; G(M1) ganglioside; Forster energy transfer
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Funding
- Swedish Research Council
- Royal Swedish Academy of Sciences
- Kempe Foundations
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New fluorophore-labelled Gm, gangliosides have been synthesised and spectroscopically characterised. Spectroscopically different BODIPY groups were covalently linked, specifically to either the polar or the hydrophobic part of the ganglioside molecule. The absorption and fluorescence spectroscopic properties are reported for 564/571-BODIPY- and 581/591-BODIPY-labelled G(M1). Each of the different BODIPY groups is highly fluorescent and depolarisation experiments provide molecular information about the spatial distribution in lipid bilayers, as well as order and dynamics. From experiments performed on two spectroscopically different BODIPY:s. specific interactions can be revealed by monitoring the rate/efficiency of donor-acceptor electronic energy transfer. Systems of particular interest for applying these probes are e.g. mixtures of lipids, and peptides/proteins interacting with lipid membranes. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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