Article
Biochemistry & Molecular Biology
Ana-Marija Vuckovic, Rina Venerando, Elena Tibaldi, Valentina Bosello Travain, Antonella Roveri, Luciana Bordin, Giovanni Miotto, Giorgio Cozza, Stefano Toppo, Matilde Maiorino, Fulvio Ursini
Summary: Ferroptosis is a regulated form of cell death controlled by lipid peroxidation through GPx4 activity. Pyruvate dehydrogenase complex plays a crucial role in supporting ferroptosis by generating superoxide. Depletion of GSH activates superoxide production by inhibiting a specific kinase that inhibits pyruvate dehydrogenase.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Plant Sciences
Chang Hyung Lee, Hee Yang, Jung Han Yoon Park, Jong-Eun Kim, Ki Won Lee
Summary: This study found that Piceatannol can alleviate symptoms of atopic dermatitis and has the potential to serve as a therapeutic agent by inhibiting the phosphorylation of JAKSTAT proteins. Through interaction with JAK1, Piceatannol may have a mechanism of action for treating atopic dermatitis.
Article
Biochemistry & Molecular Biology
Albert W. Girotti, Witold Korytowski
Summary: This review discusses how peroxidation of unsaturated phospholipids, glycolipids, and cholesterol can lead to various pathological conditions, with a focus on cholesterol-derived hydroperoxides. The study shows that cholesterol hydroperoxides can exacerbate oxidative damage by translocating within cells, impairing key cellular functions.
Article
Biochemistry & Molecular Biology
Giuliana Cardozo, Mauricio Mastrogiovanni, Ari Zeida, Nicolas Viera, Rafael Radi, Anibal M. Reyes, Madia Trujillo
Summary: Human peroxiredoxin 3 (HsPrx3) is oxidized and hyperoxidized by (f)FA-OOHs, including arachidonic acid and eicosapentaenoic acid peroxidation products. Biophysical methods and molecular dynamic simulations suggest that HsPrx3 can bind hydrophobic structures and interact with the hydroperoxide group of (f)FA-OOHs. Kinetic simulation analysis supports that mitochondrial (f)FA-OOHs can lead to HsPrx3 hyperoxidation.
Article
Biochemistry & Molecular Biology
Andrey R. Suprun, Alexandra S. Dubrovina, Alexey P. Tyunin, Konstantin Kiselev
Summary: This study analyzed phenolic compounds in Russian wines for the first time and found that red wines contain more stilbenes, phenolic acids, and flavonols than white wines, with young red wines being a rich source of phenolic compounds.
Article
Food Science & Technology
Yen-Chun Koh, Dickson Chok, Chun-Han Chang, Chia-Cheng Wei, Chia-Tung Wu, Ko-Chun Cheng, Kalyanam Nagabhushanam, Chi-Tang Ho, Min-Hsiung Pan
Summary: This study aims to evaluate the preventive effect of piceatannol on glutamate-induced neurodegeneration via mitochondrial rescue. The results show that piceatannol can prevent glutamate-induced apoptosis, reduce mitochondrial reactive oxygen species accumulation, promote mitochondrial biogenesis, and preserve mitochondrial functionality. Piceatannol effectively protects dopaminergic neurons from degradation and preserves their controlled responses.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
Kampon Kaeoket, Panida Chanapiwat
Summary: Resveratrol at an optimal concentration enhances the quality of cryopreserved boar sperm, but a high concentration has detrimental effects.
Article
Chemistry, Applied
Shima Jaldani, Elham Sarfaraz Khabbaz, Melika Jooyandeh, Reza Farhoosh
Summary: By simultaneously monitoring the concentration of LOOH and CD during the peroxidation process of different oils, valuable insights into lipid peroxidation with respect to different species of diene hydroperoxides/non-hydroperoxides can be obtained.
Article
Polymer Science
Lyubomira Radeva, Denitsa Stefanova, Yordan Yordanov, Katya Kamenova, Petar D. D. Petrov, Maya K. K. Marinova, Svilen P. P. Simeonov, Magdalena Kondeva-Burdina, Virginia Tzankova, Krassimira Yoncheva
Summary: Nanogels incorporating resveratrol showed improved stability and cellular uptake, and exhibited stronger protective effects against oxidative stress compared to the non-encapsulated drug.
Article
Immunology
Eduardo P. Amaral, Taylor W. Foreman, Sivaranjani Namasivayam, Kerry L. Hilligan, Keith D. Kauffman, Caio Cesar Barbosa Bomfim, Diego L. Costa, Beatriz Barreto-Duarte, Clarissa Gurgel-Rocha, Monique Freire Santana, Marcelo Cordeiro-Santos, Elsa Du Bruyn, Catherine Riou, Kate Aberman, Robert John Wilkinson, Daniel L. Barber, Katrin D. Mayer-Barber, Bruno B. Andrade, Alan Sher
Summary: In this study, the researchers found that GPX4, an antioxidant selenoenzyme, acts as an essential regulator of cellular necrosis and host resistance in tuberculosis caused by Mycobacterium tuberculosis (Mtb) infection. The study shows that Gpx4-deficient mice display increased lung necrosis and bacterial burdens, while mice overexpressing the enzyme have decreased bacterial loads and necrosis. The findings suggest that targeting the Gpx4/GSH axis could be a potential host-directed therapy for tuberculosis.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Renata I. Zagitova, Konstantin V. Purtov, Aleksandr S. Shcheglov, Konstantin S. Mineev, Maxim A. Dubinnyi, Ivan N. Myasnyanko, Olga A. Belozerova, Vera G. Pakhomova, Valentin N. Petushkov, Natalia S. Rodionova, Vladislav A. Lushpa, Elena B. Guglya, Sergey Kovalchuk, Valeri B. Kozhemyako, Jeremy D. Mirza, Anderson G. Oliveira, Ilia V. Yampolsky, Zinaida M. Kaskova, Aleksandra S. Tsarkova
Summary: In this study, three compounds were isolated and structurally elucidated from the Chaetomorpha linum algae. These compounds showed bioluminescence activity with Chaetopterus luciferase in the presence of Fe2+ ions. They are derivatives of polyunsaturated fatty acid peroxides. The study also confirmed the broad substrate specificity of the luciferase by obtaining and demonstrating the activity of their structural analogues in the bioluminescence reaction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Plant Sciences
Cosmina-Gabriela Duta-Bratu, George Mihai Nitulescu, Dragos Paul Mihai, Octavian Tudorel Olaru
Summary: The use of natural compounds a an alternative to synthetic molecules has gained significant interest. Stilbenoids, especially resveratrol, have been extensively studied for their therapeutic potential in various diseases. Natural stilbenes possess diverse biological activities and their chemical structures and sources simplify compound isolation and drug design. While resveratrol is well-studied, further research is needed to explore the therapeutic potential of other less popular stilbenoid compounds.
Article
Engineering, Environmental
Zilin Zhou, Leigh R. Crilley, Jenna C. Ditto, Trevor C. Vandenboer, Jonathan P. D. Abbatt
Summary: Unsaturated triglycerides found in food and skin oils are reactive in ambient air, but their chemical fate in genuine indoor environments is not well understood. This study monitored the aging of oil coatings on glass surfaces and found that ozonolysis is the dominant degradation pathway for oil films in both commercial and office settings. Indoor photooxidation was found to accelerate radical formation on surfaces. The reactive oxygen species (ROS) observed may induce oxidative stress in human bodies and further investigation of their toxicological properties is warranted.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jefferson Pedroso, Sabrina Ester Schneider, Cassia Alves Lima-Rezende, Gean Pablo S. Aguiar, Liz Girardi Muller, J. Vladimir Oliveira, Angelo Piato, Anna Maria Siebel
Summary: This study investigated the effects of resveratrol and piceatannol in controlling seizures in adult zebrafish. The results showed that neither resveratrol nor piceatannol had any anticonvulsant or neuroprotective potential in adult zebrafish.
NEUROCHEMICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Himanshu Gandhi, Shikha Mahant, Abhishek Kumar Sharma, Deepak Kumar, Kamal Dua, Dinesh Kumar Chellappan, Sachin Kumar Singh, Gaurav Gupta, Alaa A. A. Aljabali, Murtaza M. Tambuwala, Deepak N. Kapoor
Summary: Piceatannol is a natural compound found in fruits and vegetables, with a wide range of beneficial effects such as anti-inflammatory, antioxidant, anti-aging, and antidiabetic properties. It has shown promising potential in inhibiting the growth of various cancers. However, its bioavailability is lower compared to resveratrol, and further research is needed to enhance its effectiveness.
Article
Medical Laboratory Technology
Benoit Rucheton, Flavie Ader, David Goudenege, Sandrine Filaut, Laura Legrand, Adrien Bloch, Veronique Fressart, Dominique Bonnefont-Rousselot, Fanny Mochel, Foudil Lamari, Pascale Richard, Vincent Procaccio, Sylvie Bannwarth
Summary: The molecular study of mitochondrial diseases is essential for diagnosis, given the dual genetic origin of mitochondrial DNA and nuclear DNA. Complete mtDNA sequencing is still the primary diagnostic test, followed by resequencing of nuclear genes to validate. Combining mtDNA and nuclear-encoded genes for resequencing can provide more comprehensive results and faster turnaround for mitochondrial disease patients.
ANNALES DE BIOLOGIE CLINIQUE
(2021)
Article
Medical Laboratory Technology
Denis Monneret, Matteo Fasiolo, Dominique Bonnefont-Rousselot
Summary: This study aimed to explore the relationship between high-sensitive cardiac troponin T concentration and renal markers levels. The results showed that Delta hs-cTnT was mainly associated with Delta cre in a positive and nonlinear way, and negatively associated with Delta eGFR. Considering renal function variations had a minor impact on the diagnosis rate of myocardial injury.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Article
Clinical Neurology
Aurelie Hanin, Sophie Demeret, Jerome Alexandre Denis, Vi-Huong Nguyen-Michel, Benjamin Rohaut, Clemence Marois, Francoise Imbert-Bismut, Dominique Bonnefont-Rousselot, Pierre Levy, Vincent Navarro, Virginie Lambrecq
Summary: The study discussed the relationship between neuron-specific enolase (NSE) and S100-beta (S100B) levels with EEG activity to evaluate seizure risk in patients with acute brain injury. It was found that NSE levels were positively correlated with EEG scores, and higher NSE levels were associated with an increased risk of seizure recurrence.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Gastroenterology & Hepatology
Vincent Mallet, Lucia Parlati, Alessandro Martinino, Juan Pablo Scarano Pereira, Carmen Navas Jimenez, Mehdi Sakka, Samir Bouam, Aurelia Retbi, Donika Krasteva, Jean-Francois Meritet, Michael Schwarzinger, Dominique Thabut, Pierre Rufat, Dominique Bonnefont-Rousselot, Philippe Sogni, Stanislas Pol, Emmanuel Tsochatzis
Summary: This study investigates the risks of liver cancer and complications of liver disease in patients with type 2 diabetes. The findings suggest that alcohol use disorders are the main factor associated with complications of liver disease.
JOURNAL OF HEPATOLOGY
(2022)
Article
Clinical Neurology
Aurelie Hanin, Jerome Alexandre Denis, Valerio Frazzini, Louis Cousyn, Francoise Imbert-Bismut, Benoit Rucheton, Dominique Bonnefont-Rousselot, Clemence Marois, Virginie Lambrecq, Sophie Demeret, Vincent Navarro
Summary: This study aimed to evaluate the ability of Neuron Specific Enolase (NSE), S100-beta protein (S100B), and progranulin to diagnose Status Epilepticus (SE), and to validate their accuracy in a large cohort of patients. The results suggest that serum S100B levels may be helpful in diagnosing SE.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Aurelie Hanin, Sophie Demeret, Virginie Lambrecq, Benjamin Rohaut, Clemence Marois, Meriem Bouguerra, Alexandre Demoule, Jean-Louis Beaudeux, Randa Bittar, Jerome Alexandre Denis, Francoise Imbert-Bismut, Foudil Lamari, Benoit Rucheton, Dominique Bonnefont-Rousselot, Mario Chavez, Vincent Navarro
Summary: Prediction of mortality, functional outcome, and recovery after status epilepticus (SE) is a challenge. Clinical markers such as SE duration, SE refractoriness, and de novo SE were found to be significant independent predictors of worsening, while lipid markers and progranulin better predicted mortality. The combination of clinico-biological variables allows accurate prediction of worsening, mortality, and recovery in SE patients.
JOURNAL OF NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Meriam Messedi, Wassim Guidara, Sahar Grayaa, Walid Khrouf, Mouna Snoussi, Zouhir Bahloul, Dominique Bonnefont- Rousselot, Foudil Lamari, Fatma Ayadi
Summary: The study found that plasma levels of oxysterols are associated with inflammation and oxidative stress in Behcet's Disease (BD) patients. Specific oxysterol markers can be used to predict the activity level of BD.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wassim Guidara, Meriam Messedi, Manel Naifar, Manel Maalej, Walid Khrouf, Sahar Grayaa, Mohamed Maalej, Dominique Bonnefont-Rousselot, Foudil Lamari, Fatma Ayadi
Summary: Evidence suggests a correlation between the profile of oxysterols in plasma and clinical factors in patients with schizophrenia, potentially implicating oxysterols in the pathophysiology of the disorder. The ratio of cholestane-313,5 alpha,613-triol to total cholesterol (Tchol) may be considered an independent risk factor for schizophrenia, while cholestane-313,5 alpha,613-triol, 27-hydroxycholesterol, and cholestanol show promise as potential biomarkers for the disease.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Oncology
Barbara Matyasi, Gabor Petovari, Titanilla Danko, Henriett Butz, Istvan Liko, Peter Low, Isabelle Petit, Randa Bittar, Dominique Bonnefont-Rousselot, Zsolt Farkas, Tamas Szeniczey, Kinga Molnar, Krisztina Paloczi, Edit Buzas, Mathieu Boissan, Anna Sebestyen, Krisztina Takacs-Vellai
Summary: Communication between cancer and stromal cells through extracellular vesicles (EVs) is important for tumour progression. This study investigates the role of NME1 and NME2, proteins found in EVs, in the interplay between cancer and stromal cells. The findings suggest a link between NME-containing EVs and the regulation of tumour metabolism.
Article
Cardiac & Cardiovascular Systems
Gemma Llaurado, Bogdan Vlacho, Matthieu Wargny, Yue Ruan, Josep Franch-Nadal, Pere Domingo, Pierre Gourdy, Pierre-Jean Saulnier, Samy Hadjadj, Sarah H. Wild, Rustam Rea, Bertrand Cariou, Kamlesh Khunti, Didac Mauricio
Summary: This multinational study on hospitalized COVID-19 patients with diabetes mellitus found that previous macrovascular disease is associated with higher mortality and lower proportions admitted to ICU and treated with IMV during hospitalization.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Medical Laboratory Technology
Bertrand Lefrere, Mehdi Sakka, Salma Fourati, Antoine Levasseur, Emmanuel Curis, Corinne Cherfils, Pierre Gres, Zoe Guilbert, Jean-Marc Lacorte, Cristina Cheneviere, Randa Bittar, Dominique Bonnefont-Rousselot
Summary: This study evaluated the value of apoB48 in the diagnosis of chylous effusions and found it to be a promising marker. However, further research is needed to confirm its diagnostic efficacy in larger studies.
CLINICA CHIMICA ACTA
(2023)
Article
Endocrinology & Metabolism
Amelie Blondel, Ichraf Kraoua, Chloe Marcelino, Walid Khrouf, Dimitri Schlemmer, Benjamin Ganne, Catherine Caillaud, Gorka Fernandez-Eulate, Ilhem Ben Youssef Turki, Benjamin Dauriat, Dominique Bonnefont-Rousselot, Yann Nadjar, Foudil Lamari
Summary: GM2-Gangliosidosis is a group of inherited lysosomal storage diseases characterized by the accumulation of GM2 ganglioside. A new method based on liquid chromatography-mass spectrometry was developed to measure GM1, GM2, GM3, and GD3 molecular species. Plasma GM2 levels and the GM234:1/GM334:1 ratio were significantly higher in GM2-Gangliosidosis patients compared to controls. These findings suggest that plasma GM2 34:1 and its ratio to GM3 34:1 could be potential biomarkers for GM2-Gangliosidosis diagnosis and therapeutic monitoring.
MOLECULAR GENETICS AND METABOLISM
(2023)
Editorial Material
Medical Laboratory Technology
Bertrand Lefrere, Mehdi Sakka, Randa Bittar, Sebastien Gaujoux, Dominique Bonnefont-Rousselot
CLINICAL CHEMISTRY
(2023)
Article
Medical Laboratory Technology
Dominique Bonnefont-Rousselot, Marc Delpech, Philippe Chatron, Jean-Louis Gueant, Yves Le Bouc, Francois-Xavier Maquart, Bernard Massoubre, Nathalie Rives, Claude Vigneron
Summary: Medical biology is essential for patient care, but it faces various challenges such as poor management, lack of regulation, and the impact of technological progress. The excessive financialization and consolidation of medical biology laboratories are also concerning. The disaffection of the discipline and the lack of innovation further add to the challenges.
ANNALES DE BIOLOGIE CLINIQUE
(2022)
Article
Medical Laboratory Technology
Bertrand Letrere, Randa Bittar, Antoine Levasseur, Cecile Lambe, Elie Abi-Nader, Margaux Pontailler, Regis Gaudin, Valerie Fesel-Fouquier, Mehdi Sakka, Dominique Bonnefont-Rousselot
Summary: This article documents a case of a fourteen-month-old male patient with short-bowel syndrome who experienced thrombosis after catheter replacements. The patient was successfully treated by draining the effusion and repositioning the catheter. The article emphasizes the importance of identifying and confirming cases of pericardial effusion, such as chylopericardium, and discusses considerations for using lipid emulsions in pediatric patients with short-bowel syndrome.
ANNALES DE BIOLOGIE CLINIQUE
(2022)
