Journal
CHEMISTRY & BIOLOGY
Volume 18, Issue 10, Pages 1206-1207Publisher
CELL PRESS
DOI: 10.1016/j.chembiol.2011.10.006
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Harnessing the modular architecture of non-ribosomal peptide synthetases for combinatorial biosynthesis is a longstanding goal in chemical biology. Several recent reports illustrate how computational design and directed evolution can be used to tailor the specificity of these assembly-line enzymes.
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