Journal
CHEMICO-BIOLOGICAL INTERACTIONS
Volume 220, Issue -, Pages 75-83Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cbi.2014.06.018
Keywords
Huangshan Maofeng green tea; Polyphenols; HPLC; Antioxidant activity; Hepatoprotective effects
Funding
- National Natural Science Foundation of China [C31171678]
- Fundamental Research Funds for the Central Universities of Shaanxi Normal University, China [GK201103004]
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The study was to characterize the polyphenolic composition, antioxidant properties, and hepatoprotective effects of a polyphenols-enriched extract (HMTP) from Huangshan Maofeng green tea. HPLC analysis showed that three predominantly polyphenolic compounds present in HMTP were epigallocatechin (271.2 mu g/mg extract), rutin (239.3 mu g/mg) and epicatechin (89.3 mu g/mg). HMTP was shown to exhibit strong scavenging activities against DPPH center dot, O-2(center dot), and OH center dot, and ferric-reducing antioxidant power in vitro. Administration of HMTP at 200, 400 and 800 mg/kg bw in mice prior to CCl4 injury significantly decreased the CCl4-induced elevation of serum ALT, AST and ALP activities, and prevented an increase in hepatic MDA levels (p < 0.05). Mice with HMTP pretreatment displayed a better profile of hepatosomatic index and the improved GSH-Px and SOD activities in the liver, relative to CCl4-intoxicated mice. Liver pathological observation also confirmed the protection on CCl4-caused histological alteration, suggesting that HMTP has potential to be explored as valuable hepatoprotective function food. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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