Article
Pharmacology & Pharmacy
Mayada Mohamed Mabrouk Zayed, Heba A. Sahyon, Nemany A. N. Hanafy, Maged A. El-Kemary
Summary: This study successfully loaded Apigenin into chitosan and coated it with albumin-folic acid, improving its solubility and stability. In vitro experiments demonstrated the significant anticancer activity of Ap-CH-BSA-FANPs and its potential in treating HCC through inducing apoptosis and enhancing antioxidant activity.
Article
Plant Sciences
Jia-Hui Li, Song-Ya Li, Ming-Xue Shen, Run-Ze Qiu, Hong-Wei Fan, Ying-Bin Li
Summary: This study found that SN extract has significant inhibitory effects on rat C6 glioma, suppressing cell cloning, migration, invasion, and inducing apoptosis. SN also affected the expression of proteins related to migration, invasion, and apoptosis of tumor cells, and had inhibitory effects on tumor tissue growth and invasion.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Wanna Sa-nongdej, Sukumal Chongthammakun, Chanchai Songthaveesin
Summary: Glioma stem-like cells (GSCs) are highly resistant to treatment, and nutrient starvation could potentially improve treatment outcomes by triggering apoptotic and autophagic metabolic reprogramming in cancer cells.
Article
Biochemistry & Molecular Biology
Moumita Kundu, Subhayan Das, Suvendu Nandi, Dibakar Dhara, Mahitosh Mandal
Summary: The study found that magnolol (MGN) enhances the therapeutic effect of temozolomide (TMZ) on glioma. MGN promotes glioma cell apoptosis induced by TMZ by inhibiting NF-xB pathway-mediated MGMT activation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Oncology
Sera Kayacan, Kaan Yilancioglu, Ayse Seda Akdemir, Fatma Kaya-Dagistanli, Gulay Melikoglu, Melek Ozturk
Summary: The combination of apigenin and curcumin increased the expression levels of genes related to cell death in HeLa cells and showed a synergistic anti-tumor effect via cross-talk between processes leading to apoptosis and autophagic cell death.
ANTICANCER RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Jung Yoon Jang, Bokyung Sung, Nam Deuk Kim
Summary: Apigenin, a widely distributed flavonoid, has been extensively studied for its physiological effects, including anti-allergic, antibacterial, antidiabetic, anti-inflammatory, antioxidant, antiviral, and blood-pressure-lowering properties. Its anticancer properties are attributed to apoptosis, autophagy, necroptosis, and ferroptosis. This review aims to discuss the therapeutic potential of apigenin as a chemopreventive agent and the roles of programmed cell death mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Shaozhi Hou, Yang Song, Di Sun, Shujun Zhu, Zhenhua Wang
Summary: Xanthohumol (XN) can induce apoptosis of rat glioma C6 cells through the AIF pathway by affecting the mitochondria, leading to proliferation inhibition and cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Lv Peng, Xue Baiji, Wang Yongsheng
Summary: The study demonstrated that Scutellarin can inhibit the proliferation of rat glioma C6 cells by inducing apoptosis and regulating the expression of bax and bcl-2 proteins, thus suppressing tumor growth.
ACTA MEDICA MEDITERRANEA
(2021)
Article
Biochemistry & Molecular Biology
Sapna Mayuri Borah, Lakhon Kma, Muskan Sonam Darjee, Dikshit Deka, Anisha Lyngdoh, Rajesh N. Sharan, Taranga Jyoti Baruah
Summary: In this study, we found that apigenin can bind with WWP2 protein, promote PTEN protein levels, and induce apoptotic activity in non-small cell lung cancer cells.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Jan Panada, Valeriya Klopava, Tatsiana Kulahava, Siarhei Koran, Yaroslav Faletrov, Nina Frolova, Elena Fomina, Vladimir Shkumatov
Summary: This study synthesized four novel indole steroids and investigated their impact on rat C6 glioma proliferation. Among them, the steroid derived from dehydroepiandrosterone and tryptamine (IS-1) demonstrated the highest activity, effectively inhibiting tumor cell growth. The study also revealed the effects of indole steroids on apoptosis and autophagy, as well as the role of autophagy in cell death mechanism.
Article
Cell Biology
Suppanut Wongkularb, Tanapol Limboonreung, Patoomratana Tuchinda, Sukumal Chongthammakun
Summary: The study demonstrated that Chrysoeriol can decrease cell viability and induce apoptosis in rat C6 glioma cells by increasing the Bax/Bcl-2 ratio and cleaved caspase-3/caspase-3 ratio, while also suppressing the phosphorylation of PI3K, Akt, and mTOR in the cells. This suggests that Chrysoeriol may have potential antineoplastic effects on glioma cells through the PI3K/Akt/mTOR signaling pathway.
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
(2022)
Article
Chemistry, Medicinal
Hang Yu, Xi Huang, Cong Xie, Jingrong Song, Yaolong Zhou, Hanlin Shi, Mengmeng Chen, Yueren Wu, Zhenhui Ruan, Lingling Deng, Xiaohong Deng, Yubao Lv, Qingli Luo, Jingcheng Dong
Summary: Persistent chronic inflammation and airway remodeling are important pathological features of chronic asthma. Apigenin (API), a natural compound with anti-inflammatory and antioxidant properties, has shown potential in treating chronic asthma, but its specific role is not well understood.
PHYTOTHERAPY RESEARCH
(2023)
Article
Neurosciences
Alejandro Sanchez-Melgar, Sonia Munoz-Lopez, Jose Luis Albasanz, Mairena Martin
Summary: Gliomas are the most common and aggressive primary tumors in the central nervous system, while resveratrol, a natural polyphenol, shows antitumoral potential, possibly through regulating adenosine metabolism and adenosine receptors.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Oncology
Dong Wang, Zhijun Wang, Xuedong Dai, Liang Zhang, Min Li
Summary: The study demonstrated that apigenin (API) could effectively inhibit the proliferation of glioma cells in a dose- and time-dependent manner, and when combined with temozolomide (TMZ), it synergistically suppressed glioma growth through the PI3K/AKT pathway.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2021)
Article
Food Science & Technology
Yan-Cui Liang, Qian Zhong, Run-Hui Ma, Zhi-Jing Ni, Kiran Thakur, Mohammad Rizwan Khan, Rosa Busquets, Jian-Guo Zhang, Zhao-Jun Wei
Summary: Apigenin (API) inhibits proliferation, induces apoptosis, and prevents migration and invasion of Ishikawa cells. The study suggests that API could be a promising dietary supplement and adjuvant chemotherapeutic agent.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Sotirios P. Fortis, Anthimia Batrinou, Hara T. Georgatzakou, Ioannis Tsamesidis, Grigorios Alvanidis, Effie G. Papageorgiou, Kontantinos Stamoulis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Anna Theocharidou, Eleana Kontonasaki, Anastasios G. Kriebardis
Summary: This study evaluated the compatibility of human blood cells with silica-based mesoporous nanomaterials (MSNs) manufactured using the solgel method, with Ca and Ce as doping elements. The results showed that these nanomaterials had no impact on the viability of lymphocytes and monocytes, but reduced the viability of granulocytes. Additionally, the expression of Pselectin in platelets and the level of internal reactive oxygen species increased when exposed to MSNs. The presence of Ce in the MSNs improved their hemocompatibility to some extent. Further research is needed to understand how MSNs may affect different blood components and design safe and effective MSNs for biomedical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Retraction
Biochemistry & Molecular Biology
Tiechao Jiang, Dongli Jiang, Dong You, Lirong Zhang, Long Liu, Qini Zhao
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
Summary: This study investigates the impact of exosomal derived miR-1246 from HQ-transformed cells on cell-to-cell communication in recipient TK6 cells. The results show that exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuping Yu, Yaming Mu, Kai Wang, Ling Wang, Chunying Wang, Zexin Yang, Yu Liu, Shuxian Li, Meihua Zhang
Summary: Fetal growth restriction (FGR) is a common complication in obstetrics, and its exact cause is unknown. In this study, we constructed 1-NP exposed pregnant mice models and found that 1-NP induced FGR. Additionally, we observed significant ferroptosis in placental trophoblasts from 1-NP exposed mice and human FGR patients. Using in vitro cell models, we demonstrated that 1-NP impaired trophoblast biological function and induced cellular ferroptosis. We also identified the ERK signaling pathway and CYP1B1 as key regulators of 1-NP-induced ferroptosis. This study provides new insights into the aetiology of FGR and the reproductive toxicity of environmental pollutants.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Lei Hou, Yingying Zhao, Shiyu Zhao, Xuexia Zhang, Xia Yao, Jianjun Yang, Ziteng Wang, Shuaibing Liu
Summary: This study systematically characterized the UGTs enzymes involved in the formation of M4 and the inhibitory effects of ciprofol and its metabolite M4 on P450s enzymes. In vitro-in vivo extrapolation and PBPK simulations were performed to predict potential drug-drug interactions caused by ciprofol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Disheng Liu, Lu Wang, Wuhua Ha, Kan Li, Rong Shen, Degui Wang
Summary: Renal fibrosis is a common outcome of renal injuries, characterized by structural destruction and functional decline of the kidneys. Hypoxia induces the activation of HIF-1 alpha, which regulates cellular metabolism, proliferation, apoptosis, and inflammation, contributing to the development of renal fibrosis. Understanding the regulation and cascade reactions mediated by HIF-1 alpha can provide new insights for studying the mechanism of renal fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Sheng Chen, Hanqing Xu, Yi He, Chen Meng, Yunhui Fan, Yunkun Qu, Yingguang Wang, Wei Zhou, Xiaojian Huang, Hongbo You
Summary: Osteoarthritis is a heterogeneous disease that affects the entire joint. This study found that Carveol can reverse the inflammatory state of macrophages, promote their anti-inflammatory effects, and protect cartilage by activating the NRF2/HO-1/NQO1 pathway and reducing ROS clearance. The results also showed that Carveol can alleviate the pathological changes of osteoarthritis in mice, suggesting its potential therapeutic efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Liyi Wei, Tingting Wang, Mingcui Luo, Shuai Zhang, Mengxi Lu, Xinli Zhou, Xuelei Cheng, Hui Wang, Dan Xu
Summary: This study found that azithromycin during pregnancy may have toxic effects on fetal hippocampal development, especially in the late pregnancy, high dose, and multi-course situation. The results also suggest that the SOX2/Wnt signaling pathway may be involved in this toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Di Wu, Faheem Ahmed Khan, Kejia Zhang, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Kaifeng Guan, Fei Sun, Chunjie Huang
Summary: Retinoic acid (RA) is a signaling molecule derived from vitamin A/retinol, with implications in various aspects of health and disease. It regulates cell functioning through both transcriptional and non-genomic mechanisms, influencing cell-fate determination, neurogenesis, visual function, inflammatory responses, and gametogenesis commitment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Bilal Murtaza, Lili Wang, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Aisha Khatoon, Xu Yongping
Summary: Mycotoxins in food pose significant concerns for food safety and public health, potentially causing a range of adverse symptoms and cancer development. Deoxynivalenol (DON) is particularly worrisome due to its harm to vital organs. Altered mycotoxins present possible risks to the environment and well-being, necessitating further research into their adverse consequences. Accurately assessing the risk posed by modified mycotoxins remains challenging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Emine Toraman, Buesra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacimueftueoglu
Summary: The study suggests that parthenolide (PTL) may have therapeutic effects in treating testicular toxicity caused by paclitaxel (PTX) through reducing oxidative stress and increasing glutathione levels. PTL also promotes the expression of genes involved in reproduction and sperm production.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Correction
Biochemistry & Molecular Biology
Cuicui Zhuang, Hui Huo, Wanfa Fu, Wanyue Huang, Lulu Han, Miao Song, Yanfei Li
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Niu
Summary: This study explores the protective effects of fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) supplementation on learning and memory impairment caused by fluoride exposure in mice. The results show that FMT and SCFAs can improve memory deficits and alleviate pathological damages caused by fluoride, possibly by activating the BDNF-PI3K/AKT pathway. Furthermore, the disordered gut microbiome caused by fluoride can be restored through frequent FMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yong Liu, Zhaofei Pang, Yadong Wang, Jichang Liu, Guanghui Wang, Jiajun Du
Summary: This study reveals that silencing PKD2 promotes ferroptosis in LUAD by increasing reactive oxygen species, malondialdehyde accumulation, intracellular iron content and cell death. Overexpression of PKD2 prevents autophagic degradation of ferritin and promotes proliferation, migration and invasion of LUAD cells. Moreover, targeting PKD2 enhances the efficacy of carboplatin through ferroptosis and apoptosis in LUAD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)