Article
Biochemistry & Molecular Biology
Dipanjan Mukherjee, Priya Singh, Soumendra Singh, Debanjona Singh Roy, Subhankar Singha, Uttam Pal, Jhimli Sengupta, Rami J. Obaid, Saleh A. Ahmed, Tanusri Saha Dasgupta, Ranjan Das, Samir Kumar Pal
Summary: The study investigates the molecular recognition and binding process between CD1 and HSA, revealing that different host vehicles can impact the rate of drug binding to the protein, thereby modulating the release rate of the drug mimic.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Aranyak Mitra, Nandini Sarkar
Summary: All proteins have the ability to transform into amyloid fibrils under specific conditions. Disulfide bonds play a crucial role in modulating the propensity of protein aggregation. Intra-molecular disulfide bonds stabilize the native structure, while intermolecular disulfide bonds aid in the aggregation process. This review analyzes the effects of these bonds on the amyloid aggregation of proteins associated with amyloid disorders.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Editorial Material
Biochemistry & Molecular Biology
Jolanta Floryszak-Wieczorek, Ewa Sobieszczuk-Nowicka, Magdalena Arasimowicz-Jelonek
Summary: Nitroxyl (HNO), a one-electron reduced and protonated congener of nitric oxide (NO), has been recently discovered in Arabidopsis thaliana. Due to its distinct chemical properties, further studies are needed to determine the impacts of HNO on physiological processes.
TRENDS IN BIOCHEMICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Che-Hong Chen, Benjamin R. Kraemer, Lucia Lee, Daria Mochly-Rosen
Summary: Human ALDH is a multigene family with 19 functional members involved in detoxification and biotransformation. Genetic mutations can lead to toxic aldehyde accumulation and human pathologies. The physiological functions and substrate specificity of many ALDH genes are still unknown.
Article
Chemistry, Physical
Yoshihiro Koyama, Seiya Shimono, Hiroaki Kishimura, Takahiro Takekiyo, Yukihiro Yoshimura, Hiroshi Abe, Kiyoto Matsuishi
Summary: The high-pressure crystal polymorph of a fluorinated ionic liquid was determined through X-ray diffraction and Raman spectroscopy, revealing irreversible changes in crystal structure upon compression and decompression. Conformational variance/invariance of the ions in the Raman spectra corresponded to the high-pressure crystal polymorph, indicating a switch in conformational variance at a specific pressure point leading to a change in crystal system. The high-pressure crystal polymorph was shown to be entirely different from the low-temperature crystal polymorph.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Spectroscopy
Hiroshi Abe, Hiroaki Kishimura, Mikio Uruichi
Summary: The crystal polymorphs of fluorinated ionic liquids (fILs) were studied at low temperature, showing a correlation between conformational flexibility and alkyl chain length.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Biochemistry & Molecular Biology
Dana Jessen-Howard, Qisheng Pan, David B. Ascher
Summary: Human aldehyde dehydrogenases (ALDHs) have a crucial role in the metabolism of both endogenous and exogenous aldehydes. Disruptions in ALDH activity can lead to the accumulation of cytotoxic aldehydes, which are associated with various diseases. This study investigates the pathogenic consequences of missense mutations in ALDHs, providing valuable insights for cancer treatment development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Bowen Lou, Jakob Morgenstern, Thomas Fleming, Carsten Sticht, Ingrid Hausser, Ruediger Hell, Hans-Peter Hammes, Julia Szendrodi, Jens Kroll, David Philipp Wohlfart, Chiara Simone Middel, Peter Paul Nawroth
Summary: Reactive carbonyl species (RCS) formed in metabolism can impair the function of DNA, proteins, and lipids, leading to organ complications. This study focuses on the regulation of glucose metabolism, hyperglycemia, and diabetic organ damage by RCS in zebrafish.
Article
Food Science & Technology
Hua Cao, Tuoyu Zhou, Haibo Tang, Pengya Feng, Gohar Ali, Pu Liu, Xiangkai Li
Summary: The genetically modified EcN has shown effectiveness in detoxifying ethanol metabolites in liver disease models, restoring liver function, inhibiting oxidative stress, lipid peroxidation, and inflammation, as well as promoting the recovery of gut microbiota homeostasis.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Environmental Sciences
Zheng Peng, Ran Wang, Xiaofeng Xia, Juan Zhang
Summary: A visualized high-throughput method was developed to screen ALDH variants, and a variant ALDH(S273N) with the highest activity was identified. This variant showed efficient degradation of acetaldehyde, making it a promising green bio-elimination technology.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Biochemistry & Molecular Biology
Suman Samantray, Olujide O. Olubiyi, Birgit Strodel
Summary: The research focuses on the biochemical importance of glycosaminoglycans (GAGs) and reveals the impact of sulfation on GAGs structure through molecular dynamics simulations, as well as the effects of increasing NaCl and KCl concentrations. The study findings suggest that sulfation at position 6 and binding of metal ions in the absence of chloride ions have significant effects on GAGs structure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Analytical
Hiroshi Abe, Yoshihiro Koyama, Takahiro Takekiyo, Yukihiro Yoshimura
Summary: The ionic liquid [C6mim][PFBS] exhibited complicated phase transitions under high pressure, which were studied using high pressure Raman spectroscopy. The competition between cation and anion conformers determined the crystal polymorph of [C6mim][PFBS]. The flexible folding cation appeared at 3.7 GPa, while the rigid [PFBS]- anion formed the gauche' conformer at 7.6 GPa for higher packing efficiency.
VIBRATIONAL SPECTROSCOPY
(2023)
Article
Multidisciplinary Sciences
Seonghee Jeon, Heewon Kang, Inhyung Cho, Sung-Il Cho
Summary: The alcohol flushing response is common among East Asians and may serve as an indicator of the health risks associated with alcohol intake. Current flushers are more likely to develop depression with a small dose of alcohol compared to never flushers.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Rundao Chen, Liangying Li, David H. H. Olson, Lidong Guo, Lihang Chen, Qiwei Yang, Qianqian Xu, Zhiguo Zhang, Qilong Ren, Jing Li, Zongbi Bao
Summary: The sequential separation of linear, mono-, and di-branched hexane isomers using a robust stacked 1D coordination polymer named Mn-dhbq is reported. The activated polymer has an optimal aperture size in the interchain space that can exclude 2,3-dimethylbutane, while the chain structure can differentiate n-hexane. By controlling the swelling of interchain spaces, the affinity between 3-methylpentane and Mn-dhbq can be deliberately changed, achieving a complete separation of a ternary mixture.
Article
Agriculture, Multidisciplinary
Xiao Li, Jing-Nan Ren, Gang Fan, Lu-Lu Zhang, Si-Yi Pan
Summary: In this study, the enzyme involved in the (+)-valencene bioconversion by Y. lipolytica was isolated, purified, and identified. It was found to be aldehyde dehydrogenase (ALDH) with the highest activity at pH 6.0 and temperature of 30 degrees C. ALDH activity was stimulated by ferrous ions and inhibited by barium, calcium, and magnesium ions. This study provides a theoretical basis and reference for the biological synthesis of citrus flavor (+)-nootkatone.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Environmental Sciences
Salmaan H. Inayat-Hussain, Masao Fukumura, A. Muiz Aziz, Chai Meng Jin, Low Wei Jin, Rolando Garcia-Milian, Vasilis Vasiliou, Nicole C. Deziel
ENVIRONMENT INTERNATIONAL
(2018)
Article
Chemistry, Medicinal
Shyh-Ming Yang, Natalia J. Martinez, Adam Yasgar, Carina Danchik, Catrine Johansson, Yuhong Wang, Bolormaa Baljinnyam, Amy Q. Wang, Xin Xu, Pranav Shah, Dorian Chef, Xinran S. Wang, Jacob Roth, Madhu Lal-Nag, James E. Dunford, Udo Oppermann, Vasilis Vasiliou, Anton Simeonov, Ajit Jadhav, David J. Maloney
JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Chemistry, Physical
Sophie Rahuel-Clermont, Raphael Bchini, Sophie Barbe, Severine Boutserin, Isabelle Andre, Francois Talfournier
Article
Biochemistry & Molecular Biology
Flavien Zannini, Anna Moseler, Raphael Bchini, Tiphaine Dhalleine, Andreas J. Meyer, Nicolas Rouhier, Jeremy Couturier
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2019)
Article
Environmental Sciences
Alaina N. Perkins, Salmaan H. Inayat-Hussain, Nicole C. Deziel, Caroline H. Johnson, Stephen S. Ferguson, Rolando Garcia-Milian, David C. Thompson, Vasilis Vasiliou
ENVIRONMENTAL RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Akiko Matsumoto, Shosuke Ito, Kazumasa Wakamatsu, Masayoshi Ichiba, Vasilis Vasiliou, Chiho Akao, Byoung-Joon Song, Mayumi Fujita
CHEMICO-BIOLOGICAL INTERACTIONS
(2019)
Article
Biochemistry & Molecular Biology
Ying Chen, Srujana Golla, Rolando Garcia-Milian, David C. Thompson, Frank J. Gonzalez, Vasilis Vasiliou
CHEMICO-BIOLOGICAL INTERACTIONS
(2019)
Article
Biochemistry & Molecular Biology
Georgia Charkoftaki, David C. Thompson, Jaya Prakash Golla, Rolando Garcia-Milian, TuKiet T. Lam, Jasper Engel, Vasilis Vasiliou
CHEMICO-BIOLOGICAL INTERACTIONS
(2019)
Article
Chemistry, Physical
Alexandre Kriznik, Marouane Libiad, Helene Le Cordier, Samia Boukhenouna, Michel B. Toledano, Sophie Rahuel-Clermont
Review
Genetics & Heredity
Brian Thompson, Emily A. Davidson, Wei Liu, Daniel W. Nebert, Elspeth A. Bruford, Hongyu Zhao, Emmanouil T. Dermitzakis, David C. Thompson, Vasilis Vasiliou
Summary: PAX genes encode highly conserved transcription factors that regulate cell differentiation and organ development. Different structural domains in PAX proteins categorize them into four groups, playing crucial roles in various human diseases.
Article
Biochemistry & Molecular Biology
Raphael Bchini, Jean-Michel Girardet, Rodnay Sormani, Eric Gelhaye, Melanie Morel-Rouhier
Summary: eEF1B gamma, an atypical member of the GST superfamily, functions as a glutathione transferase in basidiomycete Phanerochaete chrysosporium and undergoes conformational changes upon binding of oxidized glutathione. GSSG enables eEF1B gamma to physically interact with other GSTs from the Ure2p class, offering new insights into its role in cellular oxidative stress response.
Article
Ophthalmology
Brian Thompson, Ying Chen, Emily A. Davidson, Rolando Garcia-Milian, Jaya Prakash Golla, Nicholas Apostolopoulos, David J. Orlicky, Kevin Schey, David C. Thompson, Vasilis Vasiliou
Summary: The impaired GSH biosynthesis in the eyes may disrupt eye development and PAX6 function, leading to reduced expression of crystallin and specific genes in the lens and causing a distinct microphthalmia phenotype. This study suggests a potential association between ocular GSH levels and eye development outcomes.
Review
Genetics & Heredity
Georgia Charkoftaki, Yewei Wang, Monica McAndrews, Elspeth A. Bruford, David C. Thompson, Vasilis Vasiliou, Daniel W. Nebert
Review
Genetics & Heredity
Nicholas J. W. Rattray, Nicole C. Deziel, Joshua D. Wallach, Sajid A. Khan, Vasilis Vasiliou, John P. A. Ioannidis, Caroline H. Johnson
Article
Biochemistry & Molecular Biology
Sotirios P. Fortis, Anthimia Batrinou, Hara T. Georgatzakou, Ioannis Tsamesidis, Grigorios Alvanidis, Effie G. Papageorgiou, Kontantinos Stamoulis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Anna Theocharidou, Eleana Kontonasaki, Anastasios G. Kriebardis
Summary: This study evaluated the compatibility of human blood cells with silica-based mesoporous nanomaterials (MSNs) manufactured using the solgel method, with Ca and Ce as doping elements. The results showed that these nanomaterials had no impact on the viability of lymphocytes and monocytes, but reduced the viability of granulocytes. Additionally, the expression of Pselectin in platelets and the level of internal reactive oxygen species increased when exposed to MSNs. The presence of Ce in the MSNs improved their hemocompatibility to some extent. Further research is needed to understand how MSNs may affect different blood components and design safe and effective MSNs for biomedical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Retraction
Biochemistry & Molecular Biology
Tiechao Jiang, Dongli Jiang, Dong You, Lirong Zhang, Long Liu, Qini Zhao
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
Summary: This study investigates the impact of exosomal derived miR-1246 from HQ-transformed cells on cell-to-cell communication in recipient TK6 cells. The results show that exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuping Yu, Yaming Mu, Kai Wang, Ling Wang, Chunying Wang, Zexin Yang, Yu Liu, Shuxian Li, Meihua Zhang
Summary: Fetal growth restriction (FGR) is a common complication in obstetrics, and its exact cause is unknown. In this study, we constructed 1-NP exposed pregnant mice models and found that 1-NP induced FGR. Additionally, we observed significant ferroptosis in placental trophoblasts from 1-NP exposed mice and human FGR patients. Using in vitro cell models, we demonstrated that 1-NP impaired trophoblast biological function and induced cellular ferroptosis. We also identified the ERK signaling pathway and CYP1B1 as key regulators of 1-NP-induced ferroptosis. This study provides new insights into the aetiology of FGR and the reproductive toxicity of environmental pollutants.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Lei Hou, Yingying Zhao, Shiyu Zhao, Xuexia Zhang, Xia Yao, Jianjun Yang, Ziteng Wang, Shuaibing Liu
Summary: This study systematically characterized the UGTs enzymes involved in the formation of M4 and the inhibitory effects of ciprofol and its metabolite M4 on P450s enzymes. In vitro-in vivo extrapolation and PBPK simulations were performed to predict potential drug-drug interactions caused by ciprofol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Disheng Liu, Lu Wang, Wuhua Ha, Kan Li, Rong Shen, Degui Wang
Summary: Renal fibrosis is a common outcome of renal injuries, characterized by structural destruction and functional decline of the kidneys. Hypoxia induces the activation of HIF-1 alpha, which regulates cellular metabolism, proliferation, apoptosis, and inflammation, contributing to the development of renal fibrosis. Understanding the regulation and cascade reactions mediated by HIF-1 alpha can provide new insights for studying the mechanism of renal fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Sheng Chen, Hanqing Xu, Yi He, Chen Meng, Yunhui Fan, Yunkun Qu, Yingguang Wang, Wei Zhou, Xiaojian Huang, Hongbo You
Summary: Osteoarthritis is a heterogeneous disease that affects the entire joint. This study found that Carveol can reverse the inflammatory state of macrophages, promote their anti-inflammatory effects, and protect cartilage by activating the NRF2/HO-1/NQO1 pathway and reducing ROS clearance. The results also showed that Carveol can alleviate the pathological changes of osteoarthritis in mice, suggesting its potential therapeutic efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Liyi Wei, Tingting Wang, Mingcui Luo, Shuai Zhang, Mengxi Lu, Xinli Zhou, Xuelei Cheng, Hui Wang, Dan Xu
Summary: This study found that azithromycin during pregnancy may have toxic effects on fetal hippocampal development, especially in the late pregnancy, high dose, and multi-course situation. The results also suggest that the SOX2/Wnt signaling pathway may be involved in this toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Di Wu, Faheem Ahmed Khan, Kejia Zhang, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Kaifeng Guan, Fei Sun, Chunjie Huang
Summary: Retinoic acid (RA) is a signaling molecule derived from vitamin A/retinol, with implications in various aspects of health and disease. It regulates cell functioning through both transcriptional and non-genomic mechanisms, influencing cell-fate determination, neurogenesis, visual function, inflammatory responses, and gametogenesis commitment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Bilal Murtaza, Lili Wang, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Aisha Khatoon, Xu Yongping
Summary: Mycotoxins in food pose significant concerns for food safety and public health, potentially causing a range of adverse symptoms and cancer development. Deoxynivalenol (DON) is particularly worrisome due to its harm to vital organs. Altered mycotoxins present possible risks to the environment and well-being, necessitating further research into their adverse consequences. Accurately assessing the risk posed by modified mycotoxins remains challenging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Emine Toraman, Buesra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacimueftueoglu
Summary: The study suggests that parthenolide (PTL) may have therapeutic effects in treating testicular toxicity caused by paclitaxel (PTX) through reducing oxidative stress and increasing glutathione levels. PTL also promotes the expression of genes involved in reproduction and sperm production.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Correction
Biochemistry & Molecular Biology
Cuicui Zhuang, Hui Huo, Wanfa Fu, Wanyue Huang, Lulu Han, Miao Song, Yanfei Li
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Niu
Summary: This study explores the protective effects of fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) supplementation on learning and memory impairment caused by fluoride exposure in mice. The results show that FMT and SCFAs can improve memory deficits and alleviate pathological damages caused by fluoride, possibly by activating the BDNF-PI3K/AKT pathway. Furthermore, the disordered gut microbiome caused by fluoride can be restored through frequent FMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yong Liu, Zhaofei Pang, Yadong Wang, Jichang Liu, Guanghui Wang, Jiajun Du
Summary: This study reveals that silencing PKD2 promotes ferroptosis in LUAD by increasing reactive oxygen species, malondialdehyde accumulation, intracellular iron content and cell death. Overexpression of PKD2 prevents autophagic degradation of ferritin and promotes proliferation, migration and invasion of LUAD cells. Moreover, targeting PKD2 enhances the efficacy of carboplatin through ferroptosis and apoptosis in LUAD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)