Article
Ophthalmology
Nicholas P. Boyer, Debra A. Thompson, Yiannis Koutalos
Summary: The study investigated the contribution of all-trans retinal to the formation and stability of RPE lipofuscin in Rdh8(-/-) mice reared under cyclic-light conditions. Results showed that the levels of A2E and RPE lipofuscin accumulated faster in cyclic-light-reared mice compared to dark-reared mice, but the impact of increased all-trans retinal was modest. Additionally, moving cyclic-light-reared mice to darkness led to unexpected decreases in A2E levels, suggesting a potential therapeutic target for controlling A2E cytotoxicity.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Ye-Gi Lee, Chanwoo Kim, Liang Sun, Tae-Hee Lee, Yong-Su Jin
Summary: Selective production of retinol from xylose was achieved efficiently by introducing human RDH12 and NADH oxidase into S. cerevisiae.
BIOTECHNOLOGY AND BIOENGINEERING
(2022)
Article
Microbiology
Xuan Wang, Xianhao Xu, Jiaheng Liu, Yanfeng Liu, Jianghua Li, Guocheng Du, Xueqin Lv, Long Liu
Summary: Researchers developed a high retinol-producing strain of Saccharomyces cerevisiae through pathway construction, network optimization, transporter engineering, and enzyme modification. This study lays the foundation for industrial production of retinol.
Article
Nutrition & Dietetics
Amanda D'Espessailles, Valeria Campos, Nevenka Juretic, Gladys S. Tapia, Paulina Pettinelli
Summary: The dietary supplementation of alpha- and gamma-tocopherols was found to modulate the expression of hepatic retinaldehyde dehydrogenases and lipogenic factors, reducing the presence of lipid vesicles and total lipid content in an animal model of diet-induced nonalcoholic fatty liver disease (NAFLD).
Article
Immunology
Xinrui Dong, Huijuan Dai, Aijun Sun, Zhenfeng Yu, Yueyao Du
Summary: Ten trastuzumab resistance-related genes were identified, among which DLD could be used for prediction of trastuzumab response and prognosis in HER2+ breast cancer.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
T. Cronin, M. Croyal, N. Provost, J. B. Ducloyer, A. Mendes-Madeira, L. Libeau, C. Morival, E. Toublanc, C. Audrain, C. Isiegas, V Pichard, O. Adjali
Summary: Dysfunction of the ATPase-binding Cassette Transporter protein (ABCA4) can cause early onset macular degeneration, particularly Stargardt disease. Deletion of a short exon in the ABCA4 gene significantly reduces protein levels, leading to accumulation of retinoid dimers similar to those seen in Stargardt disease.
Review
Biochemistry & Molecular Biology
Chiara Sanguinetti, Marianna Minniti, Vanessa Susini, Laura Caponi, Giorgia Panichella, Vincenzo Castiglione, Alberto Aimo, Michele Emdin, Giuseppe Vergaro, Maria Franzini
Summary: This article provides an overview of the biological life cycle of transthyretin (TTR), including its physiological metabolism and the role of mutations and physiological ligands in its stability. Understanding these mechanisms is crucial for a better comprehension of the pathogenesis of TTR amyloidosis.
Review
Biochemistry & Molecular Biology
Taihao Quan
Summary: As the most extensive and abundant tissue in the human body, the skin undergoes gradual atrophy during the aging process, causing disruptions to its structure and functionality. Recent molecular discoveries related to skin aging emphasize the importance of preventive approaches, such as the use of topical retinoids, which show promise in enhancing skin texture and thickness.
Article
Biochemistry & Molecular Biology
Wanggang Tang, Chuanyue Gui, Tingting Zhang
Summary: In this study, we successfully optimized the expression of the Mycobacterium tuberculosis Rv0439c enzyme and found that it has a preference for NADP(+) and may play a role in retinol metabolism. These findings provide a basis for future functional and structural studies of Rv0439c, contributing to a better understanding of Mtb biology.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Nutrition & Dietetics
Courtney P. Victor, Juan S. Leon, Anne M. Williams
Summary: This study aimed to evaluate the ratio of retinol to RBP in individuals with and without norovirus infection, and investigate the impact of inflammation on retinol, RBP, and the ratio between the two. The findings indicate that the ratio was the same among infected and uninfected individuals, and inflammation had an effect on both retinol and RBP. However, adjusting for inflammation did not result in the expected equivalence between retinol and RBP.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Cell Biology
Aleksander Tworak, Alexander Kolesnikov, John D. Hong, Elliot H. Choi, Jennings C. Luu, Grazyna Palczewska, Zhiqian Dong, Dominik Lewandowski, Matthew J. Brooks, Laura Campello, Anand Swaroop, Philip D. Kiser, Vladimir J. Kefalov, Krzysztof Palczewski
Summary: Using a cell-specific gene reactivation approach, we investigated the kinetics of RGR-mediated recovery of photoreceptor responses. We found that both RPE and a specialized subset of Mueuroller glia contribute to scotopic and photopic function, and demonstrated the role of 11-cis-retinal in rapid visual pigment regeneration.
Article
Genetics & Heredity
Stefania Zampatti, Cristina Peconi, Giulia Calvino, Rosangela Ferese, Stefano Gambardella, Raffaella Cascella, Jacopo Sebastiani, Benedetto Falsini, Andrea Cusumano, Emiliano Giardina
Summary: In this study, a causative gene RDH8 for Stargardt macular dystrophy was identified in a consanguineous Italian family using a combined approach and multilevel validation. The disease phenotype was consistent with previous murine models. This study provides evidence for a splicing mutation in a gene that has not been reported in human disorders before.
Article
Medical Laboratory Technology
Jacob J. Kennedy, Jeffrey R. Whiteaker, Laura C. Kennedy, Dustin E. Bosch, Melissa L. Lerch, Regine M. Schoenherr, Lei Zhao, ChenWei Lin, Shrabanti Chowdhury, Mark R. Kilgore, Kimberly H. Allison, Pei Wang, Andrew N. Hoofnagle, Geoffrey Stuart Baird, Amanda G. Paulovich
Summary: The study evaluated the analytical performance of a targeted mass spectrometry-based assay for quantifying HER2 protein in breast cancer biopsies, showing that the method can accurately measure HER2 protein levels even at low expression levels.
CLINICAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Alistair C. Leitch, Ibrahim Ibrahim, Tarek M. Abdelghany, Alex Charlton, Clair Roper, Dan Vidler, Jeremy M. Palmer, Colin Wilson, David E. Jones, Peter G. Blain, Matthew C. Wright
Summary: This study found human exposure to M8OI, which undergoes monooxygenation by cytochromes P450 followed by oxidation by alcohol and acetaldehyde dehydrogenase to a carboxylic acid, partially excreted via bile in human liver.
Review
Biochemistry & Molecular Biology
Ke Cao, Jie Xu, Wenli Cao, Xueqiang Wang, Weiqiang Lv, Mengqi Zeng, Xuan Zou, Jiankang Liu, Zhihui Feng
Summary: Mitochondrial succinate dehydrogenase (SDH) is an enzyme complex that plays a crucial role in regulating mitochondrial metabolism and human health. Recent studies have revealed the dynamic involvement of SDH assembly process in various diseases. Perturbation of SDH assembly in different tissues can lead to distinct pathophysiological changes, highlighting the importance of understanding the intricate SDH assembly process in human health and diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Olga V. Belyaeva, Chenbei Chang, Michael C. Berlett, Natalia Y. Kedishvili
CHEMICO-BIOLOGICAL INTERACTIONS
(2015)
Article
Chemistry, Medicinal
Venkatram R. Atigadda, Gang Xia, Anil Deshpande, Lizhi Wu, Natalia Kedishvili, Craig D. Smith, Helen Krontiras, Kirby I. Bland, Clinton J. Grubbs, Wayne J. Brouillette, Donald D. Muccio
JOURNAL OF MEDICINAL CHEMISTRY
(2015)
Article
Biochemistry & Molecular Biology
Josep Marti-Solans, Olga V. Belyaeva, Nuria P. Torres-Aguila, Natalia Y. Kedishvili, Ricard Albalat, Cristian Canestro
MOLECULAR BIOLOGY AND EVOLUTION
(2016)
Article
Biochemistry & Molecular Biology
Olga V. Belyaeva, Mark K. Adams, Lizhi Wu, Natalia Y. Kedishvili
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Seung-Ah Lee, Olga V. Belyaeva, Natalia Y. Kedishvili
CHEMICO-BIOLOGICAL INTERACTIONS
(2011)
Editorial Material
Biochemistry & Molecular Biology
Bryce V. Plapp, Natalia Y. Kedishvili, Tea Lanisnik Rizner, Edmund Maser, Peter J. O'Brien
CHEMICO-BIOLOGICAL INTERACTIONS
(2013)
Article
Biochemistry & Molecular Biology
Seung-Ah Lee, Olga V. Belyaeva, Natalia Y. Kedishvili
Article
Biochemistry & Molecular Biology
Seung-Ah Lee, Olga V. Belyaeva, Lizhi Wu, Natalia Y. Kedishvili
JOURNAL OF BIOLOGICAL CHEMISTRY
(2011)
Article
Biochemistry & Molecular Biology
Olga V. Belyaeva, Seung-Ah Lee, Mark K. Adams, Chenbei Chang, Natalia Y. Kedishvili
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
Article
Biochemistry & Molecular Biology
Mark K. Adams, Olga V. Belyaeva, Lizhi Wu, Natalia Y. Kedishvili
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Review
Biochemistry & Molecular Biology
Natalia Y. Kedishvili
JOURNAL OF LIPID RESEARCH
(2013)
Article
Multidisciplinary Sciences
Lizhi Wu, Sandeep C. Chaudhary, Venkatram R. Atigadda, Olga V. Belyaeva, Steven R. Harville, Craig A. Elmets, Donald D. Muccio, Mohammad Athar, Natalia Y. Kedishvili
Article
Biochemistry & Molecular Biology
Mark K. Adams, Seung-Ah Lee, Olga V. Belyaeva, Lizhi Wu, Natalia Y. Kedishvili
CHEMICO-BIOLOGICAL INTERACTIONS
(2017)
Article
Ophthalmology
Lan Wang, Chuan-Ming Li, Martin Rudolf, Olga V. Belyaeva, Byung Hong Chung, Jeffrey D. Messinger, Natalia Y. Kedishvili, Christine A. Curcio
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2009)
Article
Biochemistry & Molecular Biology
Sotirios P. Fortis, Anthimia Batrinou, Hara T. Georgatzakou, Ioannis Tsamesidis, Grigorios Alvanidis, Effie G. Papageorgiou, Kontantinos Stamoulis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Anna Theocharidou, Eleana Kontonasaki, Anastasios G. Kriebardis
Summary: This study evaluated the compatibility of human blood cells with silica-based mesoporous nanomaterials (MSNs) manufactured using the solgel method, with Ca and Ce as doping elements. The results showed that these nanomaterials had no impact on the viability of lymphocytes and monocytes, but reduced the viability of granulocytes. Additionally, the expression of Pselectin in platelets and the level of internal reactive oxygen species increased when exposed to MSNs. The presence of Ce in the MSNs improved their hemocompatibility to some extent. Further research is needed to understand how MSNs may affect different blood components and design safe and effective MSNs for biomedical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Retraction
Biochemistry & Molecular Biology
Tiechao Jiang, Dongli Jiang, Dong You, Lirong Zhang, Long Liu, Qini Zhao
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
Summary: This study investigates the impact of exosomal derived miR-1246 from HQ-transformed cells on cell-to-cell communication in recipient TK6 cells. The results show that exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuping Yu, Yaming Mu, Kai Wang, Ling Wang, Chunying Wang, Zexin Yang, Yu Liu, Shuxian Li, Meihua Zhang
Summary: Fetal growth restriction (FGR) is a common complication in obstetrics, and its exact cause is unknown. In this study, we constructed 1-NP exposed pregnant mice models and found that 1-NP induced FGR. Additionally, we observed significant ferroptosis in placental trophoblasts from 1-NP exposed mice and human FGR patients. Using in vitro cell models, we demonstrated that 1-NP impaired trophoblast biological function and induced cellular ferroptosis. We also identified the ERK signaling pathway and CYP1B1 as key regulators of 1-NP-induced ferroptosis. This study provides new insights into the aetiology of FGR and the reproductive toxicity of environmental pollutants.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Lei Hou, Yingying Zhao, Shiyu Zhao, Xuexia Zhang, Xia Yao, Jianjun Yang, Ziteng Wang, Shuaibing Liu
Summary: This study systematically characterized the UGTs enzymes involved in the formation of M4 and the inhibitory effects of ciprofol and its metabolite M4 on P450s enzymes. In vitro-in vivo extrapolation and PBPK simulations were performed to predict potential drug-drug interactions caused by ciprofol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Disheng Liu, Lu Wang, Wuhua Ha, Kan Li, Rong Shen, Degui Wang
Summary: Renal fibrosis is a common outcome of renal injuries, characterized by structural destruction and functional decline of the kidneys. Hypoxia induces the activation of HIF-1 alpha, which regulates cellular metabolism, proliferation, apoptosis, and inflammation, contributing to the development of renal fibrosis. Understanding the regulation and cascade reactions mediated by HIF-1 alpha can provide new insights for studying the mechanism of renal fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Sheng Chen, Hanqing Xu, Yi He, Chen Meng, Yunhui Fan, Yunkun Qu, Yingguang Wang, Wei Zhou, Xiaojian Huang, Hongbo You
Summary: Osteoarthritis is a heterogeneous disease that affects the entire joint. This study found that Carveol can reverse the inflammatory state of macrophages, promote their anti-inflammatory effects, and protect cartilage by activating the NRF2/HO-1/NQO1 pathway and reducing ROS clearance. The results also showed that Carveol can alleviate the pathological changes of osteoarthritis in mice, suggesting its potential therapeutic efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Liyi Wei, Tingting Wang, Mingcui Luo, Shuai Zhang, Mengxi Lu, Xinli Zhou, Xuelei Cheng, Hui Wang, Dan Xu
Summary: This study found that azithromycin during pregnancy may have toxic effects on fetal hippocampal development, especially in the late pregnancy, high dose, and multi-course situation. The results also suggest that the SOX2/Wnt signaling pathway may be involved in this toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Di Wu, Faheem Ahmed Khan, Kejia Zhang, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Kaifeng Guan, Fei Sun, Chunjie Huang
Summary: Retinoic acid (RA) is a signaling molecule derived from vitamin A/retinol, with implications in various aspects of health and disease. It regulates cell functioning through both transcriptional and non-genomic mechanisms, influencing cell-fate determination, neurogenesis, visual function, inflammatory responses, and gametogenesis commitment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Bilal Murtaza, Lili Wang, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Aisha Khatoon, Xu Yongping
Summary: Mycotoxins in food pose significant concerns for food safety and public health, potentially causing a range of adverse symptoms and cancer development. Deoxynivalenol (DON) is particularly worrisome due to its harm to vital organs. Altered mycotoxins present possible risks to the environment and well-being, necessitating further research into their adverse consequences. Accurately assessing the risk posed by modified mycotoxins remains challenging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Emine Toraman, Buesra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacimueftueoglu
Summary: The study suggests that parthenolide (PTL) may have therapeutic effects in treating testicular toxicity caused by paclitaxel (PTX) through reducing oxidative stress and increasing glutathione levels. PTL also promotes the expression of genes involved in reproduction and sperm production.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Correction
Biochemistry & Molecular Biology
Cuicui Zhuang, Hui Huo, Wanfa Fu, Wanyue Huang, Lulu Han, Miao Song, Yanfei Li
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Niu
Summary: This study explores the protective effects of fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) supplementation on learning and memory impairment caused by fluoride exposure in mice. The results show that FMT and SCFAs can improve memory deficits and alleviate pathological damages caused by fluoride, possibly by activating the BDNF-PI3K/AKT pathway. Furthermore, the disordered gut microbiome caused by fluoride can be restored through frequent FMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yong Liu, Zhaofei Pang, Yadong Wang, Jichang Liu, Guanghui Wang, Jiajun Du
Summary: This study reveals that silencing PKD2 promotes ferroptosis in LUAD by increasing reactive oxygen species, malondialdehyde accumulation, intracellular iron content and cell death. Overexpression of PKD2 prevents autophagic degradation of ferritin and promotes proliferation, migration and invasion of LUAD cells. Moreover, targeting PKD2 enhances the efficacy of carboplatin through ferroptosis and apoptosis in LUAD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)