Shedding light on protein folding landscapes by single-molecule fluorescence

Single-molecule spectroscopy of protein folding dynamics—expanding scope and timescales

(2013) Benjamin Schuler et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Modulation of allostery by protein intrinsic disorder

(2013) Allan Chris M. Ferreon et al.   NATURE

The Conformational Ensembles of α-Synuclein and Tau: Combining Single-Molecule FRET and Simulations

(2012) Abhinav Nath et al.   BIOPHYSICAL JOURNAL

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein

(2012) Nunilo Cremades et al.   CELL

Protein folding: from theory to practice

(2012) D Thirumalai et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Small-Angle X-ray Scattering and Single-Molecule FRET Spectroscopy Produce Highly Divergent Views of the Low-Denaturant Unfolded State

(2012) Tae Yeon Yoo et al.   JOURNAL OF MOLECULAR BIOLOGY

Slow Unfolded-State Structuring in Acyl-CoA Binding Protein Folding Revealed by Simulation and Experiment

(2012) Vincent A. Voelz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification of an Aggregation-Prone Structure of Tau

(2012) Shana Elbaum-Garfinkle et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural Intermediates during α-Synuclein Fibrillogenesis on Phospholipid Vesicles

(2012) Gemma Comellas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Elucidating the Role of C-Terminal Post-Translational Modifications Using Protein Semisynthesis Strategies: α-Synuclein Phosphorylation at Tyrosine 125

(2012) Mirva Hejjaoui et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Counteracting chemical chaperone effects on the single-molecule  -synuclein structural landscape

(2012) A. C. M. Ferreon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct observation of multiple misfolding pathways in a single prion protein molecule

(2012) H. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct observation of a force-induced switch in the anisotropic mechanical unfolding pathway of a protein

(2012) B. Jagannathan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conserved features of intermediates in amyloid assembly determine their benign or toxic states

(2012) R. Krishnan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantifying internal friction in unfolded and intrinsically disordered proteins with single-molecule spectroscopy

(2012) A. Soranno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Energy landscape of knotted protein folding

(2012) J. I. Sulkowska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conservation of complex knotting and slipknotting patterns in proteins

(2012) J. I. Sulkowska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Molecule Fluorescence Experiments Determine Protein Folding Transition Path Times

(2012) H. S. Chung et al.   SCIENCE

The Protein-Folding Problem, 50 Years On

(2012) K. A. Dill et al.   SCIENCE

Localizing internal friction along the reaction coordinate of protein folding by combining ensemble and single-molecule fluorescence spectroscopy

(2012) Alessandro Borgia et al.   Nature Communications

A Membrane-Bound Antiparallel Dimer of Rat Islet Amyloid Polypeptide

(2011) Abhinav Nath et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

How, when and why proteins collapse: the relation to folding

(2011) Gilad Haran   CURRENT OPINION IN STRUCTURAL BIOLOGY

Allostery in a Disordered Protein: Oxidative Modifications to α-Synuclein Act Distally To Regulate Membrane Binding

(2011) Eva Sevcsik et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Single-molecule fluorescence reveals sequence-specific misfolding in multidomain proteins

(2011) Madeleine B. Borgia et al.   NATURE

Visualizing a one-way protein encounter complex by ultrafast single-molecule mixing

(2011) Yann Gambin et al.   NATURE METHODS

The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β1−40 peptide

(2011) Priyanka Narayan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Exploring one-state downhill protein folding in single molecules

(2011) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Islet amyloid polypeptide demonstrates a persistent capacity to disrupt membrane integrity

(2011) N. B. Last et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Complex Folding Network of Single Calmodulin Molecules

(2011) J. Stigler et al.   SCIENCE

Single-molecule fluorescence spectroscopy maps the folding landscape of a large protein

(2011) Menahem Pirchi et al.   Nature Communications

Alteration of the α-Synuclein Folding Landscape by a Mutation Related to Parkinson’s Disease

(2010) Allan Chris M. Ferreon et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Theoretical Perspectives on Protein Folding

(2010) D. Thirumalai et al.   Annual Review of Biophysics

Single Molecule Characterization of α-Synuclein in Aggregation-Prone States

(2010) Adam J. Trexler et al.   BIOPHYSICAL JOURNAL

Chaperonin-Catalyzed Rescue of Kinetically Trapped States in Protein Folding

(2010) Kausik Chakraborty et al.   CELL

SDS-Induced Fibrillation of α-Synuclein: An Alternative Fibrillation Pathway

(2010) Lise Giehm et al.   JOURNAL OF MOLECULAR BIOLOGY

Extracting Rate Coefficients from Single-Molecule Photon Trajectories and FRET Efficiency Histograms for a Fast-Folding Protein

(2010) Hoi Sung Chung et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Multicolor single-molecule FRET to explore protein folding and binding

(2010) Yann Gambin et al.   Molecular BioSystems

Protein folding stability and dynamics imaged in a living cell

(2010) Simon Ebbinghaus et al.   NATURE METHODS

Net charge per residue modulates conformational ensembles of intrinsically disordered proteins

(2010) A. H. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a helical intermediate in trifluoroethanol-induced alpha-synuclein aggregation

(2010) V. L. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Charge interactions can dominate the dimensions of intrinsically disordered proteins

(2010) S. Muller-Spath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-molecule spectroscopy of protein folding in a chaperonin cage

(2010) H. Hofmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-Synuclein Binds Large Unilamellar Vesicles as an Extended Helix†

(2009) Adam J. Trexler et al.   BIOCHEMISTRY

Linking folding and binding

(2009) Peter E Wright et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Downhill versus Barrier-Limited Folding of BBL

(2009) Giovanni Settanni et al.   JOURNAL OF MOLECULAR BIOLOGY

Helix Stabilization Precedes Aqueous and Bilayer-Catalyzed Fiber Formation in Islet Amyloid Polypeptide

(2009) Jessica A. Williamson et al.   JOURNAL OF MOLECULAR BIOLOGY

Subdomain-Specific Collapse of Denatured Staphylococcal Nuclease Revealed by Single Molecule Fluorescence Resonance Energy Transfer Measurements

(2009) Pengcheng Liu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Microfluidic Device for Single-Molecule Experiments with Enhanced Photostability

(2009) Edward A. Lemke et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ultrafast microfluidic mixer with three-dimensional flow focusing for studies of biochemical kinetics

(2009) Yann Gambin et al.   LAB ON A CHIP

NMR spectroscopy brings invisible protein states into focus

(2009) Andrew J Baldwin et al.   Nature Chemical Biology

An expanding arsenal of experimental methods yields an explosion of insights into protein folding mechanisms

(2009) Alice I Bartlett et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynamics of one-state downhill protein folding

(2009) P. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interplay of  -synuclein binding and conformational switching probed by single-molecule fluorescence

(2009) A. C. M. Ferreon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct single-molecule observation of a protein living in two opposed native structures

(2009) Y. Gambin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct observation of barrier-limited folding of BBL by single-molecule fluorescence resonance energy transfer

(2009) F. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple conformations of full-length p53 detected with single-molecule fluorescence resonance energy transfer

(2009) F. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-molecule spectroscopy of the temperature-induced collapse of unfolded proteins

(2009) D. Nettels et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coordinate-dependent diffusion in protein folding

(2009) R. B. Best et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A microfluidic mixing system for single-molecule measurements

(2009) Shawn H. Pfeil et al.   REVIEW OF SCIENTIFIC INSTRUMENTS

Probing Protein-Chaperone Interactions with Single-Molecule Fluorescence Spectroscopy

(2008) Frank Hillger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Protein Folding Problem

(2008) Ken A. Dill et al.   Annual Review of Biophysics

Nonequilibrium Single Molecule Protein Folding in a Coaxial Mixer

(2008) Kambiz M. Hamadani et al.   BIOPHYSICAL JOURNAL

Monitoring Protein Conformation along the Pathway of Chaperonin-Assisted Folding

(2008) Shruti Sharma et al.   CELL

Single-Molecule FRET Reveals Structural Heterogeneity of SDS-Bound α-Synuclein

(2008) Gertjan Veldhuis et al.   CHEMBIOCHEM

From Valleys to Ridges: Exploring the Dynamic Energy Landscape of Single Membrane Proteins

(2008) Harald Janovjak et al.   CHEMPHYSCHEM

Visualization of Intrinsically Disordered Regions of Proteins by High-Speed Atomic Force Microscopy

(2008) Atsushi Miyagi et al.   CHEMPHYSCHEM

Amyloidogenesis of Natively Unfolded Proteins

(2008) Vladimir Uversky   Current Alzheimer Research

Expanding the scope of chemoselective peptide ligations in chemical biology

(2008) Anouk Dirksen et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Protein folding studied by single-molecule FRET

(2008) Benjamin Schuler et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Downhill versus Barrier-Limited Folding of BBL 1: Energetic and Structural Perturbation Effects upon Protonation of a Histidine of Unusually Low pKa

(2008) Eyal Arbely et al.   JOURNAL OF MOLECULAR BIOLOGY

Downhill versus Barrier-Limited Folding of BBL 2: Mechanistic Insights from Kinetics of Folding Monitored by Independent Tryptophan Probes

(2008) Hannes Neuweiler et al.   JOURNAL OF MOLECULAR BIOLOGY

Membrane-Bound α-Synuclein Forms an Extended Helix: Long-Distance Pulsed ESR Measurements Using Vesicles, Bicelles, and Rodlike Micelles

(2008) Elka R. Georgieva et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Probing Transient Copper Chaperone−Wilson Disease Protein Interactions at the Single-Molecule Level with Nanovesicle Trapping

(2008) Jaime J. Benítez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A General and Efficient Method for the Site-Specific Dual-Labeling of Proteins for Single Molecule Fluorescence Resonance Energy Transfer

(2008) Eric M. Brustad et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Visualizing interaction of proteins relevant to Alzheimer’s disease in intact cells

(2008) Anne V. Thomas et al.   METHODS

A practical guide to single-molecule FRET

(2008) Rahul Roy et al.   NATURE METHODS

From the first protein structures to our current knowledge of protein folding: delights and scepticisms

(2008) Alan R. Fersht   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Direct characterization of amyloidogenic oligomers by single-molecule fluorescence

(2008) A. Orte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA