Finding needles in a basestack: recognition of mismatched base pairs in DNA by small molecules

A Novel CUGexp·MBNL1 Inhibitor with Therapeutic Potential for Myotonic Dystrophy Type 1

(2013) Amin Haghighat Jahromi et al.   ACS Chemical Biology

Multiple and Cooperative Binding of Fluorescence Light-up Probe Thioflavin T with Human Telomere DNA G-Quadruplex

(2013) Valérie Gabelica et al.   BIOCHEMISTRY

Cationic perylenediimide as a specific fluorescent binder to mismatch containing DNA

(2013) Tadao Takada et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Ligand-induced electron spin-assembly on a DNA tile

(2013) Hiroshi Atsumi et al.   CHEMICAL COMMUNICATIONS

Formation of a Thymine-HgII-Thymine Metal-Mediated DNA Base Pair: Proposal and Theoretical Calculation of the Reaction Pathway

(2013) Jakub Šebera et al.   CHEMISTRY-A EUROPEAN JOURNAL

Luminescence of [Ru(bpy)2(dppz)]2+ Bound to RNA Mismatches

(2013) Anna J. McConnell et al.   INORGANIC CHEMISTRY

Selective recognition of ds-DNA cavities by a molecular rotor: switched fluorescence of thioflavin T

(2013) Lingling Liu et al.   Molecular BioSystems

Systematic investigation of cancer-associated somatic point mutations in SNP databases

(2013) HyunChul Jung et al.   NATURE BIOTECHNOLOGY

Single-molecule study of the CUG repeat–MBNL1 interaction and its inhibition by small molecules

(2013) Amin Haghighat Jahromi et al.   NUCLEIC ACIDS RESEARCH

The structural basis of actinomycin D–binding induces nucleotide flipping out, a sharp bend and a left-handed twist in CGG triplet repeats

(2013) Yu-Sheng Lo et al.   NUCLEIC ACIDS RESEARCH

Molecular Rotors: What Lies Behind the High Sensitivity of the Thioflavin-T Fluorescent Marker

(2012) Nadav Amdursky et al.   ACCOUNTS OF CHEMICAL RESEARCH

Logic gates for multiplexed analysis of Hg2+ and Ag+

(2012) Guiyun Zhang et al.   ANALYST

AgI Ion Mediated Formation of a C-A Mispair by DNA Polymerases

(2012) Tatsuya Funai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A small molecule regulates hairpin structures in d(CGG) trinucleotide repeats

(2012) Masaki Hagihara et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A dimeric form of N-methoxycarbonyl-2-amino-1,8-naphthyridine bound to the A–A mismatch in the CAG/CAG base triad in dsRNA

(2012) Kazuhiko Nakatani et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Selective recognition of G–G mismatch using the double functional probe with electrochemical activeferrocenyl

(2012) Hanping He et al.   BIOSENSORS & BIOELECTRONICS

Investigating the Binding Mode of an Inhibitor of the MBNL1⋅RNA Complex in Myotonic Dystrophy Type 1 (DM1) Leads to the Unexpected Discovery of a DNA-Selective Binder

(2012) Chun-Ho Wong et al.   CHEMBIOCHEM

Molecular Recognition of T:G Mismatched Base Pairs in DNA as Studied by Electrospray Ionization Mass Spectrometry

(2012) Federico Riccardi Sirtori et al.   ChemMedChem

There and back again: new single-molecule insights in the motion of DNA repair proteins

(2012) Maria Spies   CURRENT OPINION IN STRUCTURAL BIOLOGY

Detecting DNA Mismatches with Metallo-Insertors: A Molecular Simulation Study

(2012) Attilio V. Vargiu et al.   INORGANIC CHEMISTRY

Luminescent Properties of Ruthenium(II) Complexes with Sterically Expansive Ligands Bound to DNA Defects

(2012) Anna J. McConnell et al.   INORGANIC CHEMISTRY

Cell-Selective Biological Activity of Rhodium Metalloinsertors Correlates with Subcellular Localization

(2012) Alexis C. Komor et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thioflavin T as an Efficient Inducer and Selective Fluorescent Sensor for the Human Telomeric G-Quadruplex DNA

(2012) Jyotirmayee Mohanty et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal structure of Δ-[Ru(bpy)2dppz]2+ bound to mismatched DNA reveals side-by-side metalloinsertion and intercalation

(2012) Hang Song et al.   Nature Chemistry

Double threading through DNA: NMR structural study of a bis-naphthalene macrocycle bound to a thymine–thymine mismatch

(2012) Muriel Jourdan et al.   NUCLEIC ACIDS RESEARCH

Differential Targeting of Unpaired Bases within Duplex DNA by the Natural Compound Clerocidin: A Valuable Tool to Dissect DNA Secondary Structure

(2012) Matteo Nadai et al.   PLoS One

Label-free DNA hybridization detection and single base-mismatch discrimination using CE-ICP-MS assay

(2011) Yan Li et al.   ANALYST

Oligonucleotide-based label-free Hg2+ assay with a monomer–excimer fluorescence switch

(2011) Yongxiang Wang et al.   ANALYST

Detection of mercury and phenylmercury ions using DNA-based fluorescent probe

(2011) Yang-Wei Lin et al.   ANALYST

A fishnet electrochemical Hg2+sensing strategy based on gold nanoparticle-bioconjugate and thymine–Hg2+–thymine coordination chemistry

(2011) Xuemei Tang et al.   ANALYST

Ligand-Assisted Complex Formation of Two DNA Hairpin Loops

(2011) Changfeng Hong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selective Cytotoxicity of Rhodium Metalloinsertors in Mismatch Repair-Deficient Cells

(2011) Russell J. Ernst et al.   BIOCHEMISTRY

Small Molecule Modulates Hairpin Structures in CAG Trinucleotide Repeats

(2011) Masaki Hagihara et al.   CHEMBIOCHEM

Fluorescent trimethyl-substituted naphthyridine as a ligand for C–C mismatch detection in CCG trinucleotide repeats

(2011) Yusuke Sato et al.   CHEMICAL COMMUNICATIONS

Ligand inducible assembly of a DNA tetrahedron

(2011) Chikara Dohno et al.   CHEMICAL COMMUNICATIONS

A highly selective and sensitive on–off sensor for silver ions and cysteine by light scattering technique of DNA-functionalized gold nanoparticles

(2011) Da-Qian Feng et al.   CHEMICAL COMMUNICATIONS

Functional nucleic acid-based electrochemiluminescent biosensor for interaction study and detection of Ag+ ions and cysteine

(2011) Chun-Xia Tang et al.   CHEMICAL COMMUNICATIONS

Designing label-free DNA sequences to achieve controllable turn-off/on fluorescence response for Hg2+ detection

(2011) Zece Zhu et al.   CHEMICAL COMMUNICATIONS

A simple “molecular beacon”-based fluorescent sensing strategy for sensitive and selective detection of mercury (ii)

(2011) Huifeng Xu et al.   CHEMICAL COMMUNICATIONS

A simple and label-free sensor for mercury(ii) detection in aqueous solution by malachite green based on a resonance scattering spectral assay

(2011) Yuangen Wu et al.   CHEMICAL COMMUNICATIONS

Control of DNA hybridization by photoswitchable molecular glue

(2011) Chikara Dohno et al.   CHEMICAL SOCIETY REVIEWS

Site-Specific DNA-Programmed Growth of Fluorescent and Functional Silver Nanoclusters

(2011) Zhenzhen Huang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Molecular-Glue-Triggered DNA Assembly To Form a Robust and Photoresponsive Nano-Network

(2011) Chunyan Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Oligonucleotide-Based Luminescent Detection of Metal Ions

(2011) Dik-Lung Ma et al.   Chemistry-An Asian Journal

Label-free emission assay of mercuric ions using DNA duplexes of poly(dT)

(2011) Byul Nim Oh et al.   DALTON TRANSACTIONS

Preferential base pairing modes of T·T mismatches

(2011) Guoyun He et al.   FEBS LETTERS

Naphthyridine tetramer with a pre-organized structure for 1:1 binding to a CGG/CGG sequence

(2011) Chikara Dohno et al.   NUCLEIC ACIDS RESEARCH

Selective inhibition of MBNL1–CCUG interaction by small molecules toward potential therapeutic agents for myotonic dystrophy type 2 (DM2) †

(2011) Chun-Ho Wong et al.   NUCLEIC ACIDS RESEARCH

Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis

(2011) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Positive cooperativity of the specific binding between Hg2+ ion and T:T mismatched base pairs in duplex DNA

(2011) Hidetaka Torigoe et al.   THERMOCHIMICA ACTA

Sensitive and selective localized surface plasmon resonance light-scattering sensor for Ag+ with unmodified gold nanoparticles

(2010) Chengke Wu et al.   ANALYST

Quantitative detection of Ag+ and cysteine using G-quadruplex–hemin DNAzymes

(2010) De-Ming Kong et al.   ANALYST

A novel single-labeled fluorescent oligonucleotide probe for silver(i) ion detection based on the inherent quenching ability of deoxyguanosines

(2010) Lei Wang et al.   ANALYST

Incorporation of Thymine Nucleotides by DNA Polymerases through T-HgII-T Base Pairing

(2010) Hidehito Urata et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Detection of Damaged DNA Bases by DNA Glycosylase Enzymes

(2010) Joshua I. Friedman et al.   BIOCHEMISTRY

Programmed assembly of organic radicals on DNA

(2010) Kensuke Maekawa et al.   CHEMICAL COMMUNICATIONS

Recognition and regulation of unique nucleic acid structures by small molecules

(2010) Guangtao Song et al.   CHEMICAL COMMUNICATIONS

A “turn-on” electrochemiluminescent biosensor for detecting Hg2+ at femtomole level based on the intercalation of Ru(phen)32+ into ds-DNA

(2010) Chun-Xia Tang et al.   CHEMICAL COMMUNICATIONS

Pyrimidine–pyrimidine base pairs stabilized by silver(i) ions

(2010) Hidehito Urata et al.   CHEMICAL COMMUNICATIONS

HgIIIon Specifically Binds with T:T Mismatched Base Pair in Duplex DNA

(2010) Hidetaka Torigoe et al.   CHEMISTRY-A EUROPEAN JOURNAL

Detection of T-T Mismatches Using Mass Spectrometry: Specific Interactions of Hg(II) with Oligonucleotides Rich in Thymine (T)

(2010) Janna Anichina et al.   JOURNAL OF PHYSICAL CHEMISTRY B

NMR Solution Structure of a DNA−Actinomycin D Complex Containing a Non-Hydrogen-Bonding Pair in the Binding Site

(2010) Shannen L. Cravens et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mismatch repair deficient colorectal cancer in the era of personalized treatment

(2010) Madeleine Hewish et al.   Nature Reviews Clinical Oncology

Detection of single nucleotide polymorphisms by the specific interaction between transition metal ions and mismatched base pairs in duplex DNA

(2010) Hidetaka Torigoe et al.   TRANSITION METAL CHEMISTRY

Highly Sensitive Electrochemical Sensor for Mercury(II) Ions by Using a Mercury-Specific Oligonucleotide Probe and Gold Nanoparticle-Based Amplification

(2009) Zhiqiang Zhu et al.   ANALYTICAL CHEMISTRY

Multiplexed Analysis of Hg2+and Ag+Ions by Nucleic Acid Functionalized CdSe/ZnS Quantum Dots and Their Use for Logic Gate Operations

(2009) Ronit Freeman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Light-Driven Supramolecular Optical Switch

(2009) Shin-nosuke Uno et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Bulky Rhodium Complex Bound to an Adenosine-Adenosine DNA Mismatch: General Architecture of the Metalloinsertion Binding Mode

(2009) Brian M. Zeglis et al.   BIOCHEMISTRY

Investigating the Biochemical Impact of DNA Damage with Structure-Based Probes: Abasic Sites, Photodimers, Alkylation Adducts, and Oxidative Lesions

(2009) Heidi A. Dahlmann et al.   BIOCHEMISTRY

The effect of linker length on binding affinity of a photoswitchable molecular glue for DNA

(2009) Chikara Dohno et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Colorimetric detection of mercury ion (Hg2+) based on DNA oligonucleotides and unmodified gold nanoparticles sensing system with a tunable detection range

(2009) Xiaowen Xu et al.   BIOSENSORS & BIOELECTRONICS

Highly sensitive and selective detection of silver ions and silver nanoparticles in aqueous solution using an oligonucleotide-based fluorogenic probe

(2009) Yen-Hsiu Lin et al.   CHEMICAL COMMUNICATIONS

An ultrasensitive electrochemical “turn-on” label-free biosensor for Hg2+with AuNP-functionalized reporter DNA as a signal amplifier

(2009) Rong-Mei Kong et al.   CHEMICAL COMMUNICATIONS

An Overview of Chemical Processes That Damage Cellular DNA: Spontaneous Hydrolysis, Alkylation, and Reactions with Radicals

(2009) Kent S. Gates   CHEMICAL RESEARCH IN TOXICOLOGY

Macrocyclic DNA-Mismatch-Binding Ligands: Structural Determinants of Selectivity

(2009) Anton Granzhan et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Fluorescent Bisanthracene Macrocycle Discriminates between Matched and Mismatch-Containing DNA

(2009) Anton Granzhan et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Small Molecule Affecting the Replication of Trinucleotide Repeat d(GAA)n

(2009) Hanping He et al.   CHEMISTRY-A EUROPEAN JOURNAL

Specific Recognition of DNA by Small Molecules

(2009) Y. Du et al.   CURRENT MEDICINAL CHEMISTRY

Photoswitchable Unsymmetrical Ligand for DNA Hetero-Mismatches

(2009) Chikara Dohno et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

DNA mismatch repair deficiency in sporadic colorectal cancer and Lynch syndrome

(2009) George Poulogiannis et al.   HISTOPATHOLOGY

Sensitivity of Ru(bpy)2dppz2+Luminescence to DNA Defects

(2009) Mi Hee Lim et al.   INORGANIC CHEMISTRY

Structure-specific binding of [Co(phen)2(HPIP)]3+ to a DNA duplex containing sheared G:A mismatch base pairs

(2009) Huili Chen et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

A Pseudocatenane Structure Formed between DNA and A Cyclic Bisintercalator

(2009) Yongjun Chu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DNA Mismatch Binding and Antiproliferative Activity of Rhodium Metalloinsertors

(2009) Russell J. Ernst et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Sequence-Dependent Formation of Fluorescent Silver Nanoclusters in Hybridized DNA Duplexes for Single Nucleotide Mutation Identification

(2009) Weiwei Guo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Influence of substituent modifications on the binding of 2-amino-1,8-naphthyridines to cytosine opposite an AP site in DNA duplexes: thermodynamic characterization

(2009) Yusuke Sato et al.   NUCLEIC ACIDS RESEARCH

Synthesis and Reaction of DNA Oligomers Containing Modified Cytosines Related to Bisulfite Sequencing

(2009) Yoshimi Oka et al.   ORGANIC LETTERS

A simple ligand that selectively targets CUG trinucleotide repeats and inhibits MBNL protein binding

(2009) J. F. Arambula et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly sensitive fluorescent sensor for mercury ion based on photoinduced charge transfer between fluorophore and π-stacked T–Hg(II)–T base pairs

(2009) Liangqia Guo et al.   TALANTA

DNA repair: easy to visualize, difficult to elucidate

(2009) Zita Nagy et al.   TRENDS IN CELL BIOLOGY

Oligonucleotide-Based Fluorescence Probe for Sensitive and Selective Detection of Mercury(II) in Aqueous Solution

(2008) Cheng-Kang Chiang et al.   ANALYTICAL CHEMISTRY

Highly Sensitive Detection of Mercury(II) Ions by Fluorescence Polarization Enhanced by Gold Nanoparticles

(2008) Bang-Ce Ye et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dimer of 2,7-diamino-1,8-naphthyridine for the detection of mismatches formed by pyrimidine nucleotide bases

(2008) Akio Kobori et al.   BIOORGANIC & MEDICINAL CHEMISTRY

DNA Labeling by Ligand Inducible Secondary Structure

(2008) Tao Peng et al.   CHEMBIOCHEM

Highly sensitive and selective detection of Hg2+ in aqueous solution with mercury-specific DNA and Sybr Green I

(2008) Jing Wang et al.   CHEMICAL COMMUNICATIONS

Specific interactions between silver(i) ions and cytosine–cytosine pairs in DNA duplexes

(2008) Akira Ono et al.   CHEMICAL COMMUNICATIONS

Binding of Ru(bpy)2(eilatin)2+to Matched and Mismatched DNA

(2008) Brian M. Zeglis et al.   INORGANIC CHEMISTRY

The terminal binding of base mismatched oligonucleotide d(CCGAATGAGG)2 by [Co(phen)2(DPQ)]Cl3

(2008) Huili Chen et al.   INORGANIC CHEMISTRY COMMUNICATIONS

Mechanism of MutS Searching for DNA Mismatches and Signaling Repair

(2008) Ingrid Tessmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

One-Step, Room Temperature, Colorimetric Detection of Mercury (Hg2+) Using DNA/Nanoparticle Conjugates

(2008) Xuejia Xue et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Sensitive and Selective Detection of Mercury Ions by Using Oligonucleotides, DNA Intercalators, and Conjugated Polymers

(2008) Xinsheng Ren et al.   LANGMUIR

DNA mismatch repair: Molecular mechanism, cancer, and ageing

(2008) Peggy Hsieh et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Selective recognition of pyrimidine–pyrimidine DNA mismatches by distance-constrained macrocyclic bis-intercalators

(2008) Matthias Bahr et al.   NUCLEIC ACIDS RESEARCH