Journal
CHEMICAL RESEARCH IN TOXICOLOGY
Volume 25, Issue 11, Pages 2490-2498Publisher
AMER CHEMICAL SOC
DOI: 10.1021/tx3003092
Keywords
-
Funding
- Colt Foundation
- European Community [266835]
- Cosmetics Europe
Ask authors/readers for more resources
This study outlines how mechanistic organic chemistry related to covalent bond formation can be used to rationalize the ability of low molecular weight chemicals to cause respiratory sensitization. The results of an analysis of 104 chemicals which have been reported to cause respiratory sensitization in humans showed that most of the sensitizing chemicals could be distinguished from 82 control chemicals for which no clinical reports of respiratory sensitization exist. This study resulted in the development of a set of mechanism-based structural alerts for chemicals with the potential to cause respiratory sensitization. Their potential for use in a predictive algorithm for this purpose alongside an externally validated quantitative structure activity relationship model is discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available