Journal
CHEMICAL RESEARCH IN TOXICOLOGY
Volume 25, Issue 8, Pages 1571-1573Publisher
AMER CHEMICAL SOC
DOI: 10.1021/tx300326m
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Funding
- National Institutes of Health [NIH R01 GM084906]
- China Scholarship Council [2011635138]
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Radiolabeled anthranilic diamide insecticide [N-(CH3)-H-3]chlorantraniliprole was synthesized at high specific activity. It was compared with phthalic diamide insecticide flubendiamide and [H-3]ryanodine in radioligand binding studies with house fly muscle membranes to provide the first direct evidence with a native insect ryanodine receptor that the major anthranilic and phthalic diamide insecticides bind at different allosterically coupled sites, i.e., there are three distinct Ca2+-release channel targets for insecticide action.
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