Article
Psychiatry
Ming-Chen Tsai, Chia-Lin Tsai, Chih-Sung Liang, Yu-Kai Lin, Guan-Yu Lin, Chia-Kuang Tsai, Po-Kuan Yeh, Yi Liu, Kuo-Sheng Hung, Fu-Chi Yang
Summary: This study investigates the genetic association between depression and migraine in the Han Chinese population in Taiwan. The results suggest that variants in the CDH4 intron region, NTRK3-AS1 downstream region, and between LINC01918 and GPR45 are associated with depression. Additionally, 20 susceptibility loci are found within different migraine subtypes. These findings provide genetic candidates for further research on the comorbidity of depression and migraine.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Genetics & Heredity
Guangqiang Meng, Peng Li, Mingying Li, Yuyan Wu, Yuechan Ma, Tao Sun, Chunyan Ji
Summary: This study investigated the association of KLK2 SNPs rs198977 and rs2664155 with AML. The results showed that the TT genotype of KLK2 rs198977 is associated with increased susceptibility to AML and hyperleukocytosis. However, no significant correlation was found between KLK2 rs2664155 and AML.
FRONTIERS IN GENETICS
(2023)
Article
Orthopedics
Baojie Li, Xiaojing Li, Linjing Zhang, Leming Mou
Summary: This study performed a meta-analysis to investigate the association between the ADAMTS14 rs4747096 polymorphism and osteoarthritis (OA) risk. The results showed a significant correlation between the rs4747096 polymorphism and OA risk in the allele, additive, and dominant genetic models.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Microbiology
Jelmer B. Jukema, Bernice M. Hoenderboom, Birgit H. B. van Benthem, Marianne A. B. Van der Sande, Henry J. C. de Vries, Christian J. P. A. Hoebe, Nicole H. T. M. Dukers-Muijrers, Caroline J. Bax, Servaas A. Morre, Sander Ouburg
Summary: Clear inter-individual differences in response to C. trachomatis infections exist, with certain genes' SNPs potentially influencing susceptibility and severity. NOD1 and IL10 gene SNPs may increase the risk of infection and late complications such as ectopic pregnancy or infertility. Further confirmatory studies on a larger scale are needed to explore the role of SNPs in CT infections.
Review
Oncology
Guanwu Wang, Lara Rosaline Heij, Dong Liu, Edgar Dahl, Sven Arke Lang, Tom Florian Ulmer, Tom Luedde, Ulf Peter Neumann, Jan Bednarsch
Summary: This systematic review evaluated the association between single-nucleotide polymorphisms (SNPs) and cholangiocarcinoma (CCA), focusing on tumorigenesis and prognosis. Based on 34 studies, a total of 43 SNPs in 32 genes associated with CCA risk, metastatic progression, and overall prognosis were identified. The study comprehensively described the mechanisms and potential clinical implications associated with these SNPs. The findings suggest that multiple SNPs play different roles at different stages of CCA and may serve as biomarkers for guiding treatment and assessing oncological risk.
Article
Oncology
Yulong Chen, Xunjun Yang, Yao Chen, Guorong Chen, Cheryl A. Winkler, Ping An, Jianxin Lyu
Summary: This study identified for the first time an association between genetic variations in SOAT1 and the occurrence of HCC, indicating a potential role of SOAT1 in the development of HCC that requires further investigation.
Article
Clinical Neurology
Yen-Feng Wang, Yi-Chu Liao, Yi-Shiang Tzeng, Shih-Pin Chen, Jiing-Feng Lirng, Jong-Ling Fuh, Wei-Ta Chen, Kuan-Lin Lai, Yi-Chung Lee, Shuu-Jiun Wang
Summary: The NOTCH3 p.R544C variant is not associated with the risk or clinical manifestations of migraine. However, patients with the p.R544C variant are less likely to have pulsatile headaches and more likely to have white matter damage in the external capsule and anterior temporal lobe.
Article
Genetics & Heredity
Ze Li, Hui Gao, Yang Liu, Hongjiao Wu, Weiyuan Li, Yunce Xing, Zhi Zhang, Xuemei Zhang
Summary: The study identified that the variant genotypes of TLR4 rs7869402 and TLR4 rs7873784 reduced the risk of gastric cancer, especially among females, older subjects, non-smokers, and non-drinkers. No significant correlations were found between the other four SNPs and gastric carcinoma risk.
Article
Immunology
Chenxi Liu, Songxin Yan, Haizhen Chen, Ziyan Wu, Liubing Li, Linlin Cheng, Haolong Li, Yongzhe Li
Summary: This study found that the GTF2I rs117026326 and rs73366469 SNPs were strongly associated with SSc in the Chinese Han population, while NFKB1 rs1599961 showed a suggestive association with SSc. However, TYK2 rs2304256 was not significantly associated with SSc in this particular population.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Infectious Diseases
Felipe Dominguez Machado, Mirela Gehlen, Vitoria Schmidt Caron, Gabriel Tassi Mousquer, Graziele Lima Bello, Camila Anton, Rafaela Manzoni Bernardi, Alana Ambos Freitas, Gisela Unis, Elis Regina Dalla Costa, Maria Lucia Rosa Rossetti, Denise Rossato Silva
Summary: The genotype 5/5 and allele 5 of MIF-794 CATT (5-8) were more common among TB patients compared to controls. There was no difference in the prevalence of genotypes 7/X+8/X between cases and controls.
Article
Infectious Diseases
Wenjing Zhou, Lijuan Wu, Jiajia Song, Lin Jiao, Yi Zhou, Juan Zhou, Nian Wang, Tangyuheng Liu, Zhenzhen Zhao, Hao Bai, Tao Wu, Binwu Ying
Summary: The study found that rs10841856 in the CLEC4E gene may be associated with an increased risk of tuberculosis in male Han individuals from Western China.
BMC INFECTIOUS DISEASES
(2021)
Article
Genetics & Heredity
Jie Wei, Huan Zhang, Xiaoya Ma, Yujie Li, Wenqian Zhou, Jinping Guo, Tianbo Jin, Mingjun Hu
Summary: This study investigated the association between single nucleotide polymorphisms (SNPs) of the OR51E1 gene and glioma susceptibility in the Chinese Han population. The results showed that polymorphisms rs10768148, rs7102992, and rs10500608 were associated with glioma risk in the overall sample. Stratified analyses based on gender and age revealed specific SNP-glioma associations. Additionally, synergistic and redundant relationships between certain SNPs were identified. Overall, this study provides a basis for assessing glioma risk-associated variants in the Chinese Han population.
Article
Pathology
Lina Yu, Yunlong Li, Hui Wang, Dong Wang, Huiting Hao, DongWei Zhang, Xiao Liang, Mengdi Cai, Rongwei Guan, Jing Bai, Jingcui Yu
Summary: In this study, the association between six single nucleotide polymorphisms (SNPs) of the OVCA1 gene and the risk of gastric cancer in the Han population of northeast China was evaluated. The study found that the AA + AG genotype of rs2273981 was significantly associated with an increased risk of gastric cancer in smokers, while the AG + GG genotype of rs1131600 and the CT + TT genotype of rs2236375 were significantly associated with increased gastric tumor volume. Furthermore, the rs2273981 GG genotype increased the transcription activity of OVCA1, potentially contributing to gastric cancer development.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Multidisciplinary Sciences
Yue Zhang, Changgui Kou, Lin Jia, Yangyang Gao, Xin Li, Hao Wu, Naifei Chen, Zheng Lv
Summary: This study found an association between the rs4784227 polymorphism of CASC16 and breast cancer susceptibility, as well as its correlation with clinical characteristics of breast cancer patients. However, there was no significant association between this polymorphism and breast cancer prognosis.
Article
Biochemistry & Molecular Biology
Maria Radanova, Mariya Levkova, Galya Mihaylova, Rostislav Manev, Margarita Maneva, Rossen Hadgiev, Nikolay Conev, Ivan Donev
Summary: There is a growing interest in studying single nucleotide polymorphisms (SNPs) in microRNA (miRNA) genes, as they may be associated with susceptibility, prognosis, and treatment response in colorectal cancer (CRC). These miRNA-SNPs could serve as non-invasive biomarkers for early detection of CRC. However, contradictory findings have been reported when different research groups investigated the same SNP in a gene for a specific miRNA, highlighting the need for more case-control studies involving participants from different ethnic backgrounds. According to our review, three miRNA-SNPs - miR-146a rs2910164, miR-27a rs895819, and miR-608 rs4919510 - appear to be promising prognostic, diagnostic, and predictive biomarkers for CRC.