4.4 Article

Easily Accessible and Highly Selective Turn-on Fluorescent Sensor for Imaging Cadmium in Living Cells

Journal

CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
Volume 29, Issue 4, Pages 632-637

Publisher

HIGHER EDUCATION PRESS
DOI: 10.1007/s40242-013-3126-3

Keywords

Fluorescent sensor; Blue-shift; Cadmium; Phenothiazine; Cell-imaging

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A new schiff base of phenothiazine derivative was designed for ratiometric sensing of Cd2+ selectively. Upon the addition of Cd2+ to the solution of phenothiazine derivative, the fluorescence intensity of it was enhanced in a linear fashion and the maximum fluorescence peak exhibited a blue shift from 575 nm to 525 nm. This ratiometric fluorescent sensor displays a very high sensitivity(detection limits were 0.34 and 1.0 mu mol/L of Cd2+ using the visual fluorescence changes and UV-Vis changes, respectively), a rapid response time(< 10 s) and high selectivity for Cd2+ over other transition metal ions. Moreover, the living cells image experiments also demonstrate the value of the sensor in fluorescent visualization of Cd2+ in the environmental and biological systems.

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