Mimicking/Extracting Structure and Functions of Natural Products: Synthetic Approaches that Address Unexplored Needs in Chemical Biology

Bioorthogonal Reactions for Labeling Proteins

(2014) Kathrin Lang et al.   ACS Chemical Biology

Finding the Right (Bioorthogonal) Chemistry

(2014) David M. Patterson et al.   ACS Chemical Biology

RE12 derivatives displaying Vaccinia H1-related phosphatase (VHR) inhibition in the presence of detergent and their anti-proliferative activity against HeLa cells

(2014) Frédéric Thuaud et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Contribution of Cage-Shaped Structure of Physalins to Their Mode of Action in Inhibition of NF-κB Activation

(2013) Masaaki Ozawa et al.   ACS Medicinal Chemistry Letters

Chemical Biology of Natural Products on the Basis of Identification of Target Proteins

(2012) Minoru Ueda   CHEMISTRY LETTERS

Kinetically Controlled One-Pot Formation of DEFGH-Rings of Type B Physalins through Domino-Type Transformations

(2012) Masaki Morita et al.   ORGANIC LETTERS

Development of Novel Types of Biologically Active Compounds Based on Natural Products and Biomolecules

(2012) Go Hirai   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN

Dual-Specificity Phosphatase CDC25A/B Inhibitor Identified from a Focused Library with Nonelectrophilic Core Structure

(2012) Ayako Tsuchiya et al.   ACS Medicinal Chemistry Letters

Design and synthesis of protein kinase Cα activators based on ‘out of pocket’ interactions

(2011) Go Hirai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Studies on the Selectivity between Glycosylation and Intermolecular Aglycone Transfer of Thioglucoside in Synthesis of Lactose Derivatives

(2011) Marie Kato et al.   CHEMISTRY LETTERS

Development of a Vaccinia H1-Related (VHR) Phosphatase Inhibitor with a Nonacidic Phosphate-Mimicking Core Structure

(2011) Go Hirai et al.   ChemMedChem

Synthesis of the DFGH ring system of Type B Physalins: Highly Oxygenated, Cage-Shaped Molecules

(2009) Megumi Ohkubo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Serine/Threonine Phosphatases: Mechanism through Structure

(2009) Yigong Shi   CELL

Ginkgolic Acid Inhibits Protein SUMOylation by Blocking Formation of the E1-SUMO Intermediate

(2009) Isao Fukuda et al.   CHEMISTRY & BIOLOGY

Multidentate Small-Molecule Inhibitors ofVacciniaH1-Related (VHR) Phosphatase Decrease Proliferation of Cervix Cancer Cells

(2009) Shuangding Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

A strategy for constructing C-sialosides based on Ireland-Claisen rearrangement and its application for synthesis of CF2-linked ganglioside GM4 analog

(2009) Mikiko Sodeoka et al.   PURE AND APPLIED CHEMISTRY

Asymmetric synthesis of isobenzofuranone derivatives and their unique character as protein kinase Cα (PKCα) activators

(2009) Go Hirai et al.   TETRAHEDRON LETTERS

Fluorescent probes for bioimaging applications

(2008) Takuya Terai et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Synthesis ofCH2-Linked α(2,3)Sialylgalactose Analogue: On the Stereoselectivity of the Key Ireland-Claisen Rearrangement

(2008) Toru Watanabe et al.   ORGANIC LETTERS