Synthesis ofO-Acyl Isopeptides

Chemical Strategies for Controlling Protein Folding and Elucidating the Molecular Mechanisms of Amyloid Formation and Toxicity

(2012) Sara Butterfield et al.   JOURNAL OF MOLECULAR BIOLOGY

Chemoenzymatic Synthesis of Hydrophobic Glycoprotein: Synthesis of Saposin C Carrying Complex-Type Carbohydrate

(2012) Hironobu Hojo et al.   JOURNAL OF ORGANIC CHEMISTRY

Through the looking glass - a new world of proteins enabled by chemical synthesis

(2012) Stephen Kent et al.   JOURNAL OF PEPTIDE SCIENCE

Synthesis of Oligopeptides Through O-acyl Isopeptide Method

(2012) H. S. Lalithamba et al.   PROTEIN AND PEPTIDE LETTERS

Epimerization Free Synthesis of O-Acyl Isodipeptides Employing COMU

(2012) M. Samarasimhareddy et al.   PROTEIN AND PEPTIDE LETTERS

Self-assembly pathways of E22Δ-type amyloid β peptide mutants generated from non-aggregative O-acyl isopeptide precursors

(2011) Youhei Sohma et al.   BIOORGANIC & MEDICINAL CHEMISTRY

‘Click peptide’ using production of monomer Aβ from the O-acyl isopeptide: Application to assay system of aggregation inhibitors and cellular cytotoxicity

(2011) Youhei Sohma et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Click Peptide Concept: O-Acyl Isopeptide of Islet Amyloid Polypeptide as a Nonaggregative Precursor Molecule

(2011) Taku Yoshiya et al.   CHEMBIOCHEM

From Polyesters to Polyamides Via ON Acyl Migration: An Original Multi-Transfer Reaction

(2011) Julien Tailhades et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Contemporary strategies for peptide macrocyclization

(2011) Christopher J. White et al.   Nature Chemistry

Selenomethionine Incorporation into Amyloid Sequences Regulates Fibrillogenesis and Toxicity

(2011) Javier Martínez et al.   PLoS One

Synthesis of an O-acyl isopeptide by using native chemical ligation to efficiently construct a hydrophobic polypeptide

(2011) Youhei Sohma et al.   TETRAHEDRON LETTERS

Solution-phase synthesis of chiral O-acyl isodipeptides

(2011) Mirna El Khatib et al.   MedChemComm

A modified protocol to prepare seed-free starting solutions of amyloid-β (Aβ)1–40 and Aβ1–42 from the corresponding depsipeptides

(2010) Marten Beeg et al.   ANALYTICAL BIOCHEMISTRY

Design and Folding of [GluA4(OβThrB30)]Insulin (“Ester Insulin”): A Minimal Proinsulin Surrogate that Can Be Chemically Converted into Human Insulin

(2010) Youhei Sohma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development of a Proteolytically Stable Retro-Inverso Peptide Inhibitor of β-Amyloid Oligomerization as a Potential Novel Treatment for Alzheimer’s Disease

(2010) Mark Taylor et al.   BIOCHEMISTRY

Ester to Amide Switch Peptides Provide a Simple Method for Preparing Monomeric Islet Amyloid Polypeptide under Physiologically Relevant Conditions and Facilitate Investigations of Amyloid Formation

(2010) Ping Cao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthetic amyloid-  oligomers impair long-term memory independently of cellular prion protein

(2010) C. Balducci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Intramolecular O−N Migration Reaction on Gold Surfaces: Toward the Preparation of Well-Defined Amyloid Surfaces

(2009) Stephanie Boussert et al.   ACS Nano

“Click Peptide“: pH-Triggered in Situ Production and Aggregation of Monomer Aβ1-42

(2009) Atsuhiko Taniguchi  et al.   CHEMBIOCHEM

O-Acyl isopeptide method: efficient synthesis of isopeptide segment and application to racemization-free segment condensation

(2009) Taku Yoshiya et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Controlled in situ preparation of Aβ(1–42) oligomers from the isopeptide “iso-Aβ(1–42)”, physicochemical and biological characterization

(2009) Zsolt Bozso et al.   PEPTIDES

Activation of Protein Splicing by Protease- or Light-Triggered O to N Acyl Migration

(2008) Miquel Vila-Perelló et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total chemical synthesis of proteins

(2008) Stephen B. H. Kent   CHEMICAL SOCIETY REVIEWS

Structure – Function Relationships of Pre-Fibrillar Protein Assemblies in Alzheimers Disease and Related Disorders

(2008) F. Rahimi et al.   Current Alzheimer Research

Switching from the unfolded to the folded state of the helix-loop-helix domain of the Id proteins based on theO-acyl isopeptide method

(2008) Sebastian D. Kiewitz et al.   JOURNAL OF PEPTIDE SCIENCE

Switch Peptide via Staudinger Reaction

(2008) Natalia Nepomniaschiy et al.   ORGANIC LETTERS

Synthesis of cyclic peptides via O–N-acyl migration

(2008) Jennifer Lécaillon et al.   TETRAHEDRON LETTERS

Comparative Properties of Insulin-like Growth Factor 1 (IGF-1) and [Gly7D-Ala]IGF-1 Prepared by Total Chemical Synthesis

(2007) Youhei Sohma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The depsipeptide technique applied to peptide segment condensation: Scope and limitations

(2007) Irene Coin et al.   JOURNAL OF PEPTIDE SCIENCE