Review
Pharmacology & Pharmacy
Seth P. Forster, Erin Dippold, Tiffany Chiang
Summary: This article discusses the advantages of pharmaceutical continuous melt granulation by twin-screw extrusion, different process options and excipients, binder selection methods, and the mechanism of granulation and its impact on granule properties. It also reviews the pharmaceutical applications of melt granulation, ranging from immediate release of soluble and insoluble APIs, taste-masking, to sustained release formulations, showcasing the versatility of twin-screw melt granulation in pharmaceutical industry.
Review
Pharmacology & Pharmacy
Srushti Tambe, Divya Jain, Yashvi Agarwal, Purnima Amin
Summary: Hot-melt extrusion (HME) technology is widely used in the pharmaceutical industry for its unit operation, cost-effectiveness, solvent-free nature, and continuous manufacturing capabilities. By studying formulation and process parameters, a variety of different dosage forms can be developed. In-depth pre-formulation research is crucial for the smooth and continuous functioning of the HME process to achieve the desired product.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Review
Engineering, Chemical
Haigang Wang, Wuqiang Yang
Summary: Fluidised beds are commonly used in the pharmaceutical industry for granulation, drying, and coating, with product quality depending on the operation of the fluidisation processes. Electrical capacitance tomography (ECT) has been utilized for flow dynamics research, optimization, and process fault diagnosis and control in pharmaceutical fluidised beds. Future applications may require re-engineering of ECT sensor design and further improvement in image reconstruction.
CHEMICAL ENGINEERING SCIENCE
(2021)
Article
Pharmacology & Pharmacy
S. Van de Steene, J. Van Renterghem, V. Vanhoorne, C. Vervaet, A. Kumar, T. De Beer
Summary: The aim of this study is to increase the understanding of the granulation mechanism in twin-screw melt granulation by investigating the influence of different screw configurations on granule formation and temperature. It is found that the direction of the kneading zone and the set barrel temperature are the most influential factors on the granule temperature, and granule formation mainly occurs in the zones with more kneading action.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Chemistry, Analytical
A. Silge, Karina Weber, D. Cialla-May, L. Mueller-Boetticher, D. Fischer, J. Popp
Summary: The application of Raman spectroscopic methods in life science has made significant progress, driven by advances in instrumentation, miniaturization, and interdisciplinary dialogue. These advancements have brought new possibilities for optical sensing and chemical imaging, contributing to advanced pharmaceutical development and manufacturing. Raman sensing, with its non-destructive and label-free quality testing capabilities, is particularly valuable for process-related aspects in bioprocessing. Additionally, the trend towards personalized medicine has increased the demand for individually tailored medicines, manufactured in public pharmacies.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Engineering, Chemical
Irina D. Zakiryanova, Petr N. Mushnikov, Elena V. Nikolaeva, Yury P. Zaikov
Summary: The mechanism and kinetic parameters of the FLiNaK-CeF3 melt interaction with water vapors and oxygen in air atmosphere were investigated using various techniques including Raman and IR spectroscopy, XRD analysis, and thermodynamic modeling. The presence of a reaction disrupting the fluoride melt homogeneity was confirmed in situ by Raman spectroscopy. The kinetic equation, order, and rate constant of the chemical reaction were determined from spectral data. The obtained kinetics data can be used to model emergencies related to depressurization in a molten salt reactor.
Article
Pharmacology & Pharmacy
Tobias Gottschalk, Cihangir Ozbay, Tim Feuerbach, Markus Thommes
Summary: This study aims to find a rational approach for predetermining suitable extrusion parameters in the pharmaceutical area, where determination of the optimal process parameters for hot melt extrusion (HME) is demanding.
Article
Pharmacology & Pharmacy
Ryo Ohashi, Tatsuo Koide, Toshiro Fukami
Summary: Transmission Raman spectroscopy (TRS) has been found to have practical prediction performance for drug content in tablets, even with variations in granulation parameters. It also shows good prediction performance for tablets manufactured at different granulation scales and thicknesses. Therefore, TRS is a versatile non-destructive quantitative analysis method that can be applied in tablet manufacturing.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Michael Ghijs, Brecht Vanbillemont, Niels Nicolai, Thomas De Beer, Ingmar Nopens
Summary: Drying is a critical step in pharmaceutical wet granulation, with granule moisture content and size determining tabletting performance. Current data collection methods struggle to measure individual granule properties, but a new method using NIR-CI is developed to simultaneously characterize moisture content and size. This method has potential to gain detailed experimental insights for building robust process models.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
S. Van de Steene, J. Van Renterghem, V. Vanhoorne, C. Vervaet, A. Kumar, T. De Beer
Summary: In the pharmaceutical industry, the use of innovative continuous manufacturing technologies such as twin-screw melt granulation (TSMG) is increasing for challenging formulations. This study provides a better understanding of the granule formation during the TSMG process. The influence of screw configuration, process parameters, and formulation on granule properties and residence time distribution was investigated. It was found that different zones in the TSMG process have different effects on granulation, leading to variations in granule size, strength, porosity, and residence time.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Judith Winck, Tobias Gottschalk, Markus Thommes
Summary: A novel strategy is proposed to predict the residence time distribution and melt temperature during pharmaceutical hot-melt extrusion processes based on experimental data. The study applies an autogenic extrusion mode without external heating and cooling to process three polymers at different specific feed loads. The residence time distributions are modeled based on a two-compartment approach that couples the behavior of a pipe and a stirred tank.
Article
Pharmacology & Pharmacy
S. Van de Steene, J. Van Renterghem, V. Vanhoorne, C. Vervaet, A. Kumar, T. De Beer
Summary: This study evaluates the influence of process parameters for TSMG, mainly focusing on the effect of screw configuration combined with screw speed, throughput, and barrel temperature, to elucidate the melt granulation mechanisms. The results indicate that the screw configuration is the most influential factor, and different mechanisms are observed for different configurations and formulations.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Crystallography
Mitchell Paolello, Ilyes Bichari, Davinia Brouckaert, Mirvatte Francis, Dawn Yang, Gerard Capellades
Summary: This study developed a population balance model to investigate the feasibility of selectively inhibiting impurity crystallization kinetics. By using Raman spectroscopy for in-situ monitoring and calibrating a population balance model, the study achieved high purity close to equilibrium within the first two hours. The optimal approach for preventing impurity nucleation involves low impurity nucleation rate, high product seed purities, and adjustable crystallization time.
Article
Pharmacology & Pharmacy
Josip Matic, Milica Stankovic-Brandl, Hannes Bauer, Jessica Lovey, Sophie Martel, Christophe Herkenne, Amrit Paudel, Johannes Khinast
Summary: Pharmaceutical product development guided by Quality by Design (QbD) requires understanding of critical process parameters (CPPs) to achieve desired product critical quality attributes (CQAs). The impact of process settings on extrusion processes is well-known, but the influence of screw element cross-section geometry is still not well-researched.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Jie Ren, Shijie Mao, Jidong Lin, Ying Xu, Qiaoqiao Zhu, Ning Xu
Summary: This review summarizes the applications of Raman spectroscopy and imaging technology in the qualitative and quantitative analysis of solid tablets, quality control of the production process, drug crystal analysis, illegal drug analysis, and monitoring of drug dissolution and release in the field of drug analysis in recent years.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Chemistry, Multidisciplinary
Matthew P. Wylie, Steven E. J. Bell, Peter Nockemann, Rory Bell, Colin P. McCoy
Article
Chemistry, Multidisciplinary
Chunchun Li, Yikai Xu, Xinyuan Li, Ziwei Ye, Chaoyi Yao, Qinglu Chen, Yuanfeng Zhang, Steven E. J. Bell
ADVANCED MATERIALS INTERFACES
(2020)
Article
Spectroscopy
Chunchun Li, Lin Chai, Qinglu Chen, Ziwei Ye, Yikai Xu, Steven E. J. Bell
Summary: The study shows that by adsorbing nanoparticles onto the hydrophilic tips of metallic needles, a dual enhancement of Raman signals from microdroplets of low concentration analytes can be achieved. This method allows the detection of extremely low total amounts of analytes.
JOURNAL OF RAMAN SPECTROSCOPY
(2021)
Article
Chemistry, Analytical
Francesca Ripanti, Claudia Fasolato, Flavia Mazzarda, Simonetta Palleschi, Marina Ceccarini, Chunchun Li, Margherita Bignami, Enrico Bodo, Steven E. J. Bell, Filomena Mazzei, Paolo Postorino
Summary: This study introduces a novel method for the identification, detection, and quantification of oxidized nucleotides using micro-Raman spectroscopy and ab initio calculations. The Raman signature in the terahertz spectral range contains information on the assembly of guanine in tetrads, allowing for improved detection of oxidative damage. Furthermore, advanced spectroscopic methods combined with surface-enhanced Raman scattering on superhydrophobic substrates enable analysis of samples at very low concentrations in small volumes.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Chaoyi Yao, Hongyu Lin, Brian Daly, Yikai Xu, Warispreet Singh, H. Q. Nimal Gunaratne, Wesley R. Browne, Steven E. J. Bell, Peter Nockemann, Meilan Huang, Paul Kavanagh, A. Prasanna de Silva
Summary: This article introduces a new method to control electron/proton transfers in water by capturing or releasing molecules. By using shape-switchable hosts and inclusive binding of metal complexes, reaction rates can be controlled and it has important applications in photocatalysis, electrocatalysis, and luminescent sensing.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Analytical
Danielle M. Allen, Gisli G. Einarsson, Michael M. Tunney, Steven E. J. Bell
Summary: Although SERS is a rapid method for identifying bacteria, variation in experimental procedures can lead to considerable spectral variation. Mixing bacteria with CRSC and drying the suspension can generate highly reproducible spectra. These observations are important for the clinical applications of SERS as they highlight the challenges that need to be addressed.
ANALYTICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Yingrui Zhang, Ziwei Ye, Chunchun Li, Qinglu Chen, Wafaa Aljuhani, Yiming Huang, Xin Xu, Chunfei Wu, Steven E. J. Bell, Yikai Xu
Summary: This article introduces a method for the preparation of Pickering emulsions without the use of chemical modifiers. By using a combination of stabilizer particles and unmodified functional particles, Pickering emulsions can be constructed. This method not only unlocks the potential of Pickering emulsions, but also allows for a wide range of applications including plasmonic sensing and interfacial catalysis.
NATURE COMMUNICATIONS
(2023)
Review
Chemistry, Multidisciplinary
Yikai Xu, Yingrui Zhang, Chunchun Li, Ziwei Ye, Steven E. J. Bell
Summary: When the size of materials is reduced, nanomaterials with large surface-to-volume ratios exhibit remarkable new properties compared to their bulk counterparts. Surface chemistry plays a crucial role in catalysis, nanotechnology, and sensing applications. Surface-enhanced Raman spectroscopy (SERS) is an emerging technique that can provide detailed in situ information on surface orientation and molecule-nanosurface binding. However, the choice between surface-accessibility and plasmonic activity has limited the applications of SERS. This article discusses the development of modifier-free synthetic approaches to synthesize surface-accessible, plasmonic nanomaterials for SERS.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
Article
Biochemical Research Methods
Chunchun Li, Yingrui Zhang, Ziwei Ye, Steven E. J. Bell, Yikai Xu
Summary: This article presents a sensitive and robust characterization technique, SERS, for studying the surface chemistry of nanomaterials in real-world applications. It allows real-time observation of molecule-metal interactions and provides information on surface orientation and chemical bond formation and breaking.
Article
Chemistry, Analytical
Wafaa Aljuhani, Yingrui Zhang, Matthew P. Wylie, Yikai Xu, Colin P. McCoy, Steven E. J. Bell
Summary: This study investigates the effects of matrix components on SERS performance and the interactions between SERS-enhancing Ag and Au particles. The results demonstrate the strong signals from intrinsic marker compounds in extracted es-biofilms, as well as the hindering effect of es-biofilms on Ag colloids aggregation and SERS signals. In contrast, Au nanospheres and nanostars show improved reproducibility in SERS signals due to reduced aggregation and lower site blocking effects.
Review
Materials Science, Multidisciplinary
Chunchun Li, Yiming Huang, Xinyuan Li, Yingrui Zhang, Qinglu Chen, Ziwei Ye, Zarah Alqarni, Steven E. J. Bell, Yikai Xu
Summary: SERS is a powerful analytical technique with molecular specificity and single-molecule sensitivity, which can be combined with portable Raman spectrometers for real-life chemical analysis and fundamental studies. To overcome the high cost limitation, the development of multifunctional SERS substrates is a viable approach, including flexible, separation-enhancement-in-one, calibration-enhancement-in-one, and regeneration-enhancement-in-one substrates.
JOURNAL OF MATERIALS CHEMISTRY C
(2021)
Article
Chemistry, Analytical
Harmke S. Siebe, Qinglu Chen, Xinyuan Li, Yikai Xu, Wesley R. Browne, Steven E. J. Bell
Summary: The study presents a simple and scalable spray-deposition technique for fabricating SERS-active paper substrates, combining filtration and enhancement in a single material. These paper substrates show high activity in detecting model analytes and effectively filter interfering particles, enabling SERS detection at nanogram levels without sample pre-treatment.
Review
Chemistry, Multidisciplinary
Ziwei Ye, Chunchun Li, Qinglu Chen, Yikai Xu, Steven E. J. Bell
Summary: Self-assembly of plasmonic nanoparticles at water-oil interfaces is a cost-effective and efficient method for creating highly plasmonically active materials, which can be used for strong SERS enhancement. Various methods have been developed to induce self-assembly and fine-tune surface chemistry, but only some are compatible with SERS research, where ensuring unimpeded access of target molecules to the active surface is crucial.
Review
Chemistry, Analytical
Chunchun Li, Ziwei Ye, Yikai Xu, Steven E. J. Bell
Article
Materials Science, Biomaterials
Alvaro Carcamo-Martinez, Bronach Mallon, Juan Dominguez-Robles, A. Sara Cordeiro, Maurizio Celentano, Eneko Larraneta, Steven E. J. Belt, Ryan F. Donnelly
JOURNAL OF MATERIALS CHEMISTRY B
(2020)
Article
Engineering, Chemical
Qing Han, Mengqing Shi, Linkai Han, Di Liu, Mingwei Tong, Yuxin Xie, Zhonghua Xiang
Summary: Developing highly efficient bifunctional oxygen electrocatalysts is crucial for zinc-air flow batteries. Metal-organic frameworks (MOFs) and covalent organic polymers (COPs) have emerged as promising alternatives due to their designable and controllable atomic-level structures. However, their catalytic performances are limited by conductivity and catalytic activity. In this study, nanosheet FeNi-MOF and iron phthalocyanine rich COP hybrid materials are assembled through the pi-pi stacking effect to create highly efficient bifunctional electrocatalysts. The resulting catalyst exhibits superior catalytic performance and stability, making it a promising candidate for zinc-air flow batteries.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Daria Grigorash, Dmytro Mihrin, Rene Wugt Larsen, Erling H. Stenby, Wei Yan
Summary: The article introduces a new approach to describe the cross-association between molecules, allowing for the simulation of weakly bound molecular complexes with different conformations in mixtures. By incorporating this approach into the equation of state, accurate predictions of vapor-liquid equilibrium and liquid-liquid equilibrium can be made. The new method is validated through experiments on alcohol and acid mixtures, with the results compared to experimental data, demonstrating its accuracy and reliability.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Mohammed Al-Sharabi, Daniel Markl, Vincenzino Vivacqua, Prince Bawuah, Natalie Maclean, Andrew P. E. York, Axel Zeitler
Summary: This study used terahertz pulsed imaging to investigate the transport process of different solvents into ceramic catalytic materials. The results showed that the heating rate of the samples influenced the water transport rate, while the viscosity of 1-octanol slowed down its transport.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Chukwunonso Anyaoku, Sati Bhattacharya, Rajarathinam Parthasarathy
Summary: This study aimed to enhance understanding of settling dynamics in viscoelastic fluids by developing a semi-empirical correlation and a dimensionless ratio, which accurately described the characteristics of settling suspensions.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Antti I. Koponen, Janika Viitala, Atsushi Tanaka, Baranivignesh Prakash, Olli-Ville Laukkanen, Ari Jasberg
Summary: This study focuses on the development of foam application chemicals for the paper and board industry. The research explores the rheology of the polyvinyl alcohol foam used in the process. Measurements were conducted to determine the foam viscosity and slip flow. The results suggest that slip flow contributes significantly to the total flow rate, and the obtained viscosity and slip models provide a solid foundation for industrial processes.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Dalei Sun, Jinghui Cai, Yating Yang, Zhiwu Liang
Summary: In this study, Fe-doped alpha-Bi2O3 catalysts with different Fe/Bi molar ratios were synthesized and utilized in the carbonylation of isobutyl amine with CO2. The results showed that Fe doping significantly enhanced the catalytic abilities of alpha-Bi2O3.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Yuan Tian, Xinxin Wang, Yanrong Liu, Wenping Hu
Summary: This paper predicts the solubility of nitrogen gas in ionic liquids (ILs) using two quantitative structure-property relationship (QSPR) models. By combining machine learning methods and ionic fragments contribution method, the accuracy and reliability of the prediction models are improved.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Liwang Wang, Wei Liu, Pan Yang, Yulong Chang, Xiaoxu Duan, Lingyu Xiao, Yaoming Hu, Jiwei Wu, Liang Ma, Hualin Wang
Summary: This study investigates the effective phase interfacial area (ae) of hydro-jet cyclones at different injection angles. The results show that a 45 degrees upward incidence angle yields the most favorable flow field characteristics for efficient mass transfer. The significant enhancement in ae of the hydro-jet cyclones offers the advantage of reducing equipment volume and cost savings.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Chuanjun Wu, Jiangzhi Chen, Jiyue Sun, I-Ming Chou, Shenghua Mei, Juezhi Lin, Lei Jiang
Summary: In this study, the solubility of H2S hydrate in water was measured using Raman spectroscopy. The results showed that the solubility increases with temperature under certain equilibrium conditions, and the solubility also depends on pressure and temperature under different equilibrium conditions. A thermodynamic model based on the van der Waals-Platteeuw theory was developed to predict the solubility, demonstrating its accuracy.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Lorenzo Brivio, Serena Meini, Mattia Sponchioni, Davide Moscatelli
Summary: This study investigates the influence of three main parameters and proposes a kinetic model to predict the optimal operating conditions for high yield of dimethyl terephthalate (DMT) in the chemical recycling process of polyethylene terephthalate (PET).
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Hongju Lin, Fanhui Liao, Yanchang Chu, Mingyu Xie, Lun Pan, Yuanyuan Wang, Lijian Leng, Donghai Xu, Le Yang, Gangfeng Ouyang
Summary: A honeycomb NiCo/C-Na catalyst with a micro-meso-macroporous structure has been fabricated and shown to have significantly higher catalytic activity for the decarboxylation of fatty acids. It also proves to be efficient in upgrading sludge HTL bio-crude, resulting in a biofuel with decreased viscosity and increased density.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Xiaoxian Li, Rui Li, Min Lin, Mingde Yang, Yulong Wu
Summary: A series of coated non-noble metal porous carbon catalysts were synthesized and applied to the aqueous-phase deoxygenation of algal bio-oil. One of the catalysts showed excellent deoxygenation selectivity and catalytic activity at 250 degrees C. The catalyst exhibited good hydrothermal stability and the reaction mechanism was proposed based on product analysis and active site analysis.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
M. V. Chudakova, M. V. Popov, P. A. Korovchenko, E. O. Pentsak, A. R. Latypova, P. B. Kurmashov, A. A. Pimenov, E. A. Tsilimbaeva, I. S. Levin, A. G. Bannov, A. V. Kleymenov
Summary: A series of catalysts with different potassium contents were prepared using solution combustion synthesis and characterized using various techniques. The results showed that the potassium content affected the phase composition and texture of the catalysts. The addition of a small amount of potassium resulted in a change in particle size distribution, leading to higher hydrogen yield. The Ni-1%K2O/Al2O3 catalyst exhibited the highest hydrogen yield at temperatures of 675 and 750 degrees Celsius.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Aliakbar Roosta, Nima Rezaei
Summary: In this study, we modified the electrolyte cubic plus association equation of state (e-CPA EoS) and integrated it with two electrical conductivity models to estimate the electrical conductivity of 11 monovalent electrolyte solutions in water. The modified e-CPA model demonstrated better performance and the hybridization with electrical conductivity models resulted in two predictive models for estimating the electrical conduction of dilute and concentrated electrolyte solutions. These predictive models showed relative average percentage deviations (AARD) of 11.15% and 13.87% over wide ranges of temperature and electrolyte concentration.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Haoren Niu, Jianzheng Wang, Qingzhu Jia, Qiang Wang, Jin Zhao, Fangyou Yan
Summary: A study developed two quantitative structure-property relationship models for the complexation performance of alpha- and beta-cyclodextrins and validated their stability and predictive ability through internal and external validation. The models showed robustness and satisfactory performance, as demonstrated by the experimental results and model validations. These models can effectively predict the binding constants between cyclodextrins and various types of molecules, providing valuable tools for cyclodextrin design.
CHEMICAL ENGINEERING SCIENCE
(2024)