Review
Engineering, Chemical
Ahmad Banafi, Siaw Khur Wee, Angnes Ngieng Tze Tiong, Zong Yang Kong, Agus Saptoro, Jaka Sunarso
Summary: In recent decades, there has been a growing interest in the use of supercritical fluid for various industries, particularly in the extraction of valuable compounds from solid materials through supercritical fluid extraction (SFE). Reliable mathematical modeling is essential to optimize the SFE process and achieve maximum extraction yield. This review critically evaluates different strategies proposed for mathematical modeling of SFE process in packed bed columns, including their main features, key assumptions, mathematical expressions, and applications. It also provides a comprehensive review of studies on SFE of plant matrices, highlighting the studied systems and operational conditions.
CHEMICAL ENGINEERING RESEARCH & DESIGN
(2023)
Article
Plant Sciences
Nedasadat Saadati Ardestani, Mitra Amani, Seyed A. Sajadian
Summary: This research focused on the sc-CO2 extraction of Elaeagnus angustifolia oil and its mathematical modeling. Experimental extraction was followed by modeling the process using mass transfer equations. The effects of main operational parameters were analyzed using Box-Behnken design, and the models were optimized using Genetic algorithm. The highest extraction yield of 84.9% was achieved under the optimum conditions determined by the models. The results from ANOVA indicated the high accuracy of the mathematical models for the supercritical extraction process.
JOURNAL OF APPLIED RESEARCH ON MEDICINAL AND AROMATIC PLANTS
(2023)
Article
Engineering, Chemical
Elissandro Jair Klein, Gracielle Johann, Edson Antonio da Silva, Melissa Gurgel Adeodato Vieira
Summary: Supercritical CO(2) extracts of Eugenia pyriformis leaves may contain alpha-amyrin and beta-amyrin, bioactive compounds with various pharmacological applications. Experimental results indicated that the Freundlich isotherm model best described the extraction kinetics.
CHEMICAL ENGINEERING COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Omid Faraz, Mozhdeh Poustchi, Parsa Movahedi, Reza Shahriari, Ebrahim Nazari Denyani, Fereshteh Rajabi Kouchi
Summary: In this study, the capability of the PHSC model to predict the solubility of pharmaceuticals in pure, mixed, and supercritical solvents was evaluated. The results showed that the PHSC model can satisfactorily estimate the solubility of pharmaceuticals in different solvents and supercritical CO2.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Physical
Tales Prado Alves, Gracielle Johann, Carina Contini Triques, Edson Antonio da Silva, Marcia R. Fagundes-Klen, Pedro Yahico Ramos Suzaki, Lucio Cardozo-Filho
Summary: In this study, supercritical extractions of Monteverdia aquifolia leaves were carried out using neat CO2 at different temperatures, CO2 flow rates, and pressures. The highest yield was obtained at 300 bar, 6 mL min-1, and 50 degrees C. The study also demonstrated that leaves are a good source of bioactive and antioxidant compounds.
JOURNAL OF SUPERCRITICAL FLUIDS
(2023)
Article
Chemistry, Multidisciplinary
Sara Ahmadkelayeh, Sukhinder Kaur Cheema, Kelly Hawboldt
Summary: Shrimp processing by-products contain valuable biomaterials/bioactive materials, such as lipids and astaxanthin, which can be extracted through supercritical extraction combined with co-solvents. The extraction conditions, including pressure, carbon dioxide flow, and temperature, affect the yields and compositions of lipids and astaxanthin. Polar organic co-solvents in co-solvent experiments show higher extraction yields and concentrations of phospholipids/saturated fatty acids in the extract compared to pure supercritical CO2 extract.
JOURNAL OF CO2 UTILIZATION
(2022)
Article
Pharmacology & Pharmacy
Lucia Baldino, Mariarosa Scognamiglio, Ernesto Reverchon
Summary: This study successfully reduced harmful solvent levels in two corticosteroid drugs through supercritical CO2 extraction, where CO2 density plays a key role. Operating under specific pressure and temperature conditions for extraction can effectively lower organic solvent residues.
Article
Engineering, Chemical
Sofyane Bouali, Antoine Leybros, Guillaume Toquer, Thomas Zemb, Agnes Grandjean
Summary: The efficiency of supercritical CO2 extraction of cerium is influenced by the concentration of cerium nitrate deposits on the substrate, as well as the presence and composition of co-solvent/water mixture. Extraction efficiency is promoted when Ce nitrates deposits are in the form of segregated aggregates instead of homogeneous layers. Adding a co-solvent and adjusting the water concentration up to 30%wt are crucial to obtaining high mass extraction yields, up to 82%.
CHEMICAL ENGINEERING RESEARCH & DESIGN
(2021)
Article
Engineering, Environmental
Young-Kwon Park, Jeong-Myeong Ha, Shinyoung Oh, Jechan Lee
Summary: The study reviews the transfer hydrogenation method to upgrade bio-oil, focusing on the major factors affecting the process. It concludes by identifying future challenges and the requirements to make the transfer hydrogenation upgrading process commercially available.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Engineering, Chemical
Alessandra Zanotti, Lucia Baldino, Mariarosa Scognamiglio, Ernesto Reverchon
Summary: This study used supercritical fluid extraction to extract and separate the solid extract of lavender flowers. The results showed that higher mass flow rates resulted in higher yields, while lower mass flow rates led to lower yields.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2023)
Article
Biochemistry & Molecular Biology
Graciane Fabiela da Silva, Edgar Teixeira de Souza Junior, Rafael Nolibos Almeida, Ana Luisa Butelli Fianco, Alexandre Timm do Espirito Santo, Aline Machado Lucas, Rubem Mario Figueiro Vargas, Eduardo Cassel
Summary: In this study, non-volatile compounds were extracted from Acacia mearnsii flowers using supercritical fluid extraction for the first time. The extract showed antimicrobial activity and the presence of p-anisic acid. The extraction process was optimized to maximize the yield of p-anisic acid.
Review
Chemistry, Analytical
Quentin Gros, Johanna Duval, Caroline West, Eric Lesellier
Summary: The development of automatized hyphenated systems is attractive for avoiding sampling error, saving time, and reducing costs. Among these systems, on-line SFE-SFC allows efficient, quick, and eco-friendly extraction, separation, and detection of molecules. The principles of supercritical fluid extraction (SFE) and supercritical fluid chromatography (SFC) are discussed, along with comparisons of partially-supercritical on-line systems before examining the evolution of on-line SFE-SFC over the past decades. Different devices for better understanding coupling challenges and determining advantageous configurations are also examined.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Gowhar Ahmad Naikoo, Mohammad Saeedi Zadegan, Mona Zamani Pedram, Israr Ul Hassan, Waqar Ahmed, Golshan Yousefi Attar
Summary: The study found that using the DPTG model coupled with vdW2 in supercritical carbon dioxide extraction of Vitamin A can more accurately correlate with the solubility data, making it a more suitable method compared to others.
SCIENTIFIC REPORTS
(2021)
Review
Food Science & Technology
Hossein Ahangari, Jerry W. King, Ali Ehsani, Mohammad Yousefi
Summary: Supercritical fluid extraction (SFE) has been widely used in extracting seed oils due to its efficiency, low cost, and the ability to optimize the process through modeling. There is also a trend towards combining SFE with other extraction methods such as ultrasound-assisted extraction to enhance the extraction process.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Chemistry, Physical
F. Khodaie, S. M. Ghoreishi
Summary: This study evaluated the extraction of gallic acid from brown sumac seeds using supercritical-CO2 fluid and ethanol. Response surface methodology was employed to design and optimize experiments, resulting in a mathematical model that predicted the behavior of the extraction process. Thermodynamic equations were used to determine the optimal operating conditions.
JOURNAL OF SUPERCRITICAL FLUIDS
(2021)
Article
Materials Science, Biomaterials
Rodrigo Scopel, Manuel A. Falcao, Angelica Regina Cappellari, Fernanda B. Morrone, Silvia S. Guterres, Eduardo Cassel, Andrea M. Kasko, Rubem M. F. Vargas
Summary: In this study, vitamin D(3) functionalized hybrid lipid-polymer nanoparticles were synthesized to target melanoma cells. The nanoparticles showed efficient cellular uptake and hold promise as a delivery vehicle for melanoma treatment.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Graciane Fabiela da Silva, Edgar Teixeira de Souza Junior, Rafael Nolibos Almeida, Ana Luisa Butelli Fianco, Alexandre Timm do Espirito Santo, Aline Machado Lucas, Rubem Mario Figueiro Vargas, Eduardo Cassel
Summary: In this study, non-volatile compounds were extracted from Acacia mearnsii flowers using supercritical fluid extraction for the first time. The extract showed antimicrobial activity and the presence of p-anisic acid. The extraction process was optimized to maximize the yield of p-anisic acid.
Article
Thermodynamics
Victor Hugo S. Rodrigues, Rafael N. Almeida, Rubem M. F. Vargas, Eduardo Cassel
Summary: The main objective of this study was to determine the vapor-liquid equilibrium of the binary mixture eugenol/caryophyllene at reduced pressures and to obtain pure compounds vapor pressure data in the same low-pressure condition. Experimental data showed that the models used in this study were able to accurately calculate the temperature and vapor-phase molar fraction of the VLE system.
JOURNAL OF CHEMICAL THERMODYNAMICS
(2022)
Article
Plant Sciences
Julia M. Scopel, Bruna Medeiros-Neves, Helder Teixeira, Sergio A. L. Bordignon, Alexandre M. Fuentefria, Gabriella da Rosa Monte Machado, Rafael N. Almeida, Eduardo Cassel, Gilsane L. von Poser, Rubem M. F. Vargas
Summary: This study investigated the distillation products of Pterocaulon polystachyum and found that the essential oil exhibited antifungal activity against Microsporum gypseum, while the residual distillation water contained phenolic acids and coumarins of interest to the pharmaceutical and food industries. Additionally, a mathematical model was developed for the extraction curve.
Article
Chemistry, Applied
Rubem Mario Figueiro Vargas, Graciane Fabiela da Silva, Aline Machado Lucas, Caroline Garcia Finkler da Silva, Louise Jank, Fabiano Barreto, Eduardo Cassel
Summary: This study aimed to obtain and investigate the properties and composition of extracts from Acacia mearnsii flowers. The major compounds and scents in the essential oil were identified, and potential antioxidant activity and flavonoid composition were detected in the water-soluble extract.
JOURNAL OF ESSENTIAL OIL RESEARCH
(2023)
Article
Agronomy
Rafaela Mendonca Nozari, Luisa Machado Ramos, Laura Alcantara da Luz, Rafael Nolibos Almeida, Aline Machado Lucas, Eduardo Cassel, Silvia Dias de Oliveira, Leandro Vieira Astarita, Eliane Romanato Santar
Summary: Plant Growth Promoting Rhizobacteria (PGPR) can alleviate the detrimental effects of salinity in plants. In this study, we characterized Streptomyces spp. as halotolerant PGPR and evaluated their influence on salt stress-tolerance mechanisms in maize plants. The results showed that Streptomyces isolates had good tolerance to salt and could enhance the antioxidant system activity and osmolyte synthesis in plants. The response to salinity was observed in both roots and leaves, indicating a mechanism of systemic tolerance.
Article
Engineering, Chemical
Rafael Nolibos Almeida, Guilherme Evaldt Rossa, Jessica Haupt de Castro, Arthur Fagundes Cavassa, Rubem Mario Figueiro Vargas, Eduardo Cassel
Summary: Steam distillation is a traditional method for obtaining essential oils, but its parameters have been determined empirically. In this study, the effects of pressure, temperature, time, and bed porosity on essential oil extraction were evaluated. Piper hispidinervum C. DC essential oil showed similar yields under different pressure conditions, but the bed porosity varied. The experimental data fitted well with the model proposed by Reverchon. Fractionation of long pepper oil in a batch distillation column resulted in fractions with high purity of safrole and terpinolene. Adjusting the process variables reduced extraction time and improved cost-effectiveness and product value.
BRAZILIAN JOURNAL OF CHEMICAL ENGINEERING
(2023)
Article
Food Science & Technology
Silvia Rebocho, Francisca Mano, Eduardo Cassel, Beatriz Anacleto, Maria do Rosario Bronze, Alexandre Paiva, Ana Rita C. Duarte
Summary: This study introduces a new methodology for the selective extraction of antioxidants from mate tea leaves using NADES, leading to two distinct extracts rich in pigments and polyphenols. The use of NADES systems increased the extraction of polyphenolic components by 30% compared to traditional solvents/techniques, and the stability of antioxidants in NADES was shown to be beneficial for at least three months.
CURRENT RESEARCH IN FOOD SCIENCE
(2022)
Article
Energy & Fuels
Laura L. Trinkies, Marlene Crone, Michael Tuerk, Manfred Kraut, Roland Dittmeyer
Summary: In this study, mono- and bimetallic Pd and Pt catalysts were deposited via supercritical fluid reactive deposition (SFRD) on TiO2 coated additively manufactured substrates. The focus of this work was to evaluate the suitability of these catalysts for the direct synthesis of H2O2 in the liquid phase. The results showed that all catalysts exhibited high activity and productivity, with PdPt bimetallic catalysts showing the highest productivity and an increase in Pd loading leading to a decrease in productivity. Comparison with literature data demonstrated the high suitability of the SFRD method for the proposed application, with the added benefits of simplicity and environmental friendliness in catalyst production.
CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION
(2024)
Article
Energy & Fuels
Xiongbao Hu, Zuguo Shen, Yu Wang
Summary: It is impossible to control the outer wall temperature of the micro-combustor below the maximum allowable temperature of commercial thermoelectric generators simply through increasing the equivalent heat transfer coefficient. Three simple strategies were developed to improve temperature uniformity, yet none of them could ensure full temperature control.
CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION
(2024)
