Article
Biochemistry & Molecular Biology
Olivier E. Nonga, Darja Lavogina, Erki Enkvist, Katrin Kestav, Apirat Chaikuad, Sarah E. Dixon-Clarke, Alex N. Bullock, Sergei Kopanchuk, Taavi Ivan, Ramesh Ekambaram, Kaido Viht, Stefan Knapp, Asko Uri
Summary: The X-ray crystallographic study of PIM-1 protein kinase complexes with three inhibitors revealed simplified chemical structures with reduced polar groups and chiral centers, which showed low-nanomolar potency and high selectivity towards PIM kinases. The developed inhibitors were functionalized with biotin or fluorescent dye Cy5 for detection in biochemical solutions and complex biological samples. Utilizing a PIM-2 selective detection antibody, a sandwich assay was able to detect as low as 44 pg of active recombinant PIM-2.
Review
Biochemistry & Molecular Biology
Greta Bergamaschi, Pierangelo Metrangolo, Valentina Dichiarante
Summary: Researchers are continuously seeking versatile and high-performing optical bioimaging and biosensing probes, including photoluminescent metal nanoclusters. These nanoclusters, with molecule-like quantization properties, have great potential for applications in biologically relevant molecules.
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2022)
Article
Chemistry, Analytical
Hyoje Jung, Sang-Hyun Park, Won Ho Yang, Jin Won Cho, Injae Shin
Summary: In this study, we developed five fluorogenic probes to detect O-GlcNAcase in live cells. One of these probes, beta-GlcNAc-FC, was found to be the most effective substrate for O-GlcNAcase. Using this probe, we observed variations in O-GlcNAcase activity in different cell types and its correlation with glucose concentration. Furthermore, ER and mitochondrial stresses did not affect O-GlcNAcase activity.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Physical
Shorooq A. Alomar, Luis Gutierrez-Arzaluz, Issatay Nadinov, Ru He, Xiaodan Wang, Jian-Xin Wang, Jiangtao Jia, Osama Shekhah, Mohamed Eddaoudi, Husam N. Alshareef, Kirk S. Schanze, Omar F. Mohammed
Summary: Structural modifications to molecular systems that control photon emission processes are crucial for the development of fluorescence sensors, X-ray imaging scintillators, and OLEDs. This study explored the effects of slight changes in chemical structure on interfacial excited-state transfer processes using two donor-acceptor systems. The results showed efficient energy transfer in the SDZ-TADF system and both energy and electron transfer processes in the Ac-SDZ-TADF system. Transient absorption measurements and TD-DFT calculations confirmed the occurrence of photoinduced electron transfer in the Ac-SDZ-TADF system. This work provides a straightforward approach to modulate excited-state energy/charge transfer processes at donor-acceptor interfaces.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Review
Biochemistry & Molecular Biology
Sanghyuck Lee, Chul Soon Park, Hyeonseok Yoon
Summary: Recent research on photoluminescent molecules has had a significant impact on advancing the field of bioimaging due to their unique properties. Small molecules and organic dots show great potential as probes for bioimaging. This review provides an introduction to fluorescent small molecules and polymers that emit light in the ultraviolet and near-infrared ranges, and summarizes recent techniques for bioimaging. Different photoluminescence probes have different goals and strategies, which have been gradually introduced in the literature. This review focuses on the photophysical properties and design strategies of molecular probes, with key examples of in vivo photoluminescence research for practical applications. Further studies on these probes will provide valuable insights for expanding bioimaging research and applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Inorganic & Nuclear
Qingtao Meng, Miaomiao Wu, Zhuye Shang, Zhiqiang Zhang, Run Zhang
Summary: Magnetic resonance imaging (MRI) is a widely used molecular imaging technology in biomedical and clinical diagnostics. Responsive MRI probes based on gadolinium(III) (Gd(III)) complexes, which can detect and visualize target analytes, have been systematically summarized in this work. The development of strategies, the progresses in developing Gd(III) complex-based responsive MRI probes for different target analytes, and the limitations and future research directions are discussed.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Engineering, Chemical
Dharshana Nalatamby, Florence Gibouin, Javier Ordonez-Hernandez, Julien Renaudeau, Geirald Clisson, Norberto Farfan, Pierre Lidon, Yaocihuatl Medina-Gonzalez
Summary: Viscosity plays a determinant role in various industrial fluid processes and is especially important at the micro- and nanoscale. This study focuses on the use of fluorescent molecular rotors to quantitatively measure viscosity in confined and complex microfluidic flows. The technique is validated in controlled situations and then applied to passive micromixers to characterize and quantify mixing efficiency. This methodology provides a new approach for viscosity characterization in heterogeneous and complex systems.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Sirilak Wangngae, Kantapat Chansaenpak, Tunyawat Khrootkaew, Rung-Yi Lai, Anyanee Kamkaew
Summary: In this study, pH-sensitive and hypoxia-responsive probes based on vanillin and the indole ring (Val-Hcys) were synthesized. The fluorescence of the probes can be activated at acidic pH and significantly increased when incubated with hypoxic cells. These probes tend to accumulate in lysosomes and mitochondria, and surprisingly, improve cell viability in hypoxic conditions.
BIOORGANIC CHEMISTRY
(2022)
Review
Chemistry, Analytical
Jiamu Cao, Rongji Zhang, Liang Chen, Dongbo Wang, Weiqi Wang, Endong Tan, Xianghe Meng, Huaxin Xiu, Lin Wang, Xinglian Yang, Zhoumin Yang, Qijun Yang, Liancheng Zhao
Summary: Responsive metal-based luminescence probes, with advantages of large Stokes shifts, long lifetimes, high photostabilities, and easy ligand addition, are considered better alternatives to organic ones. This paper reviews critical strategies of achieving response by different stimulus sources and presents the current challenges and future opportunities of responsive metal-based luminescence probes.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Sellamuthu Anbu, Lawerence Kenning, Graeme J. Stasiuk
Summary: A novel manganese(ii) chelate based on diacetylpyridylcarbohydrazide-DAPyCOHz with dipicolylamine/zinc(ii) arms (MnLDPA-Zn2) was developed for adenosine triphosphate (ATP) responsive magnetic resonance imaging (MRI) T-1 contrast applications. Compound 2 shows enhanced relaxivity upon selective ATP binding over other phosphates.
CHEMICAL COMMUNICATIONS
(2023)
Review
Chemistry, Multidisciplinary
Hui Jia, Yiheng Liu, Jing-Jing Hu, Guogang Li, Xiaoding Lou, Fan Xia
Summary: This article reviews the key advances in lifetime-based responsive probes in recent years and discusses their applications and challenges in the field of bioanalysis.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Jeremy Salaam, Thibault Fogeron, Guillaume Pilet, Radu Bolbos, Christophe Bucher, Lhoussain Khrouz, Jens Hasserodt
Summary: Two mononuclear ferric complexes show a 27- and 71-fold increase in their ability to accelerate the relaxation rate of water-hydrogen nuclei in response to a pH change. This performance is unprecedented and holds promise for addressing sensitivity issues in Molecular MRI development. The complexes also exhibit complete reversibility and fatigue-less nature. The macrocyclic nature of the hexa-dentate ligand and the presence of a single pendant arm with a five-membered lactam or carbamate contribute to this exceptional performance.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Nanoscience & Nanotechnology
Hui Zhang, Zhuohao Zhang, Han Zhang, Canwen Chen, Dagan Zhang, Yuanjin Zhao
Summary: The development of controllable responsive microparticles composed of natural polymer materials, loaded with growth factors and antibacterial peptides, shows promising potential for drug release and wound healing applications. Under near-infrared (NIR) irradiation, these microparticles can achieve desired controllable release of growth factors to promote neovascularization formation. Additionally, the antibacterial peptides embedded in the microparticles provide antibacterial ability during storage and usage. These characteristics make the microparticles ideal for drug delivery and wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Oncology
Stefan Gerstenecker, Lisa Haarer, Martin Schroder, Mark Kudolo, Martin P. Schwalm, Valentin Wydra, Ricardo A. M. Serafim, Apirat Chaikuad, Stefan Knapp, Stefan Laufer, Matthias Gehringer
Summary: S6K1 and S6K2 are two human p70 ribosomal S6 kinases associated with various cellular processes and pathologies, particularly cancer. While S6K1 has been well studied and selectively targeted by inhibitors, S6K2 has been neglected despite potential as an anticancer target. By utilizing a unique cysteine residue in S6K2, a highly selective inhibitor was developed, paving the way for specific S6K2 signaling studies.
Article
Chemistry, Analytical
Yong Cheng, Alex E. Clark, Wonjun Yim, Raina M. Borum, Yu-Ci Chang, Zhicheng Jin, Tengyu He, Aaron F. Carlin, Jesse V. Jokerst
Summary: TMPRSS2 is a protease that activates coronaviruses and promotes tumor progression. Inhibiting TMPRSS2 can reduce cancer invasion and prevent SARS-CoV-2 infection. Researchers have developed a responsive peptide-conjugated probe that can selectively image and screen TMPRSS2 inhibitors, which may have value in cancer detection, SARS-CoV-2 targeting, and protease inhibitor screening.
ANALYTICAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Siyuan Tang, Miguel Garzon Sanz, Oliver Smith, Andreas Kraemer, Daniel Egbase, Paul W. Caton, Stefan Knapp, Sam Butterworth
Summary: The cofactor NAD thorn plays a crucial role in physiological processes and enhancing healthy aging. Recent studies have shown that NAMPT activators can increase NAD thorn levels and have beneficial effects. The structure activity relationships of these activators were evaluated and it was hypothesized that they act via a through-water interaction in the NAMPT active site, leading to the design of a urea-class NAMPT activator with similar or greater activity compared to known analogues.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Biochemistry & Molecular Biology
Darja Lavogina, Naila Nasirova, Tanel Sormus, Taavo Tahtjarv, Erki Enkvist, Kaido Viht, Toiv Haljasorg, Koit Herodes, Jana Jaal, Asko Uri
Summary: In this research, we designed a series of ARCs and their fluorescent derivatives to investigate their interactions with members of the protein arginine methyltransferase (PRMT) family. Our results showed that ARCs and arginine-rich peptides could serve as high-affinity ligands for PRMT1, and the equilibrium dissociation constant values were dependent on the number of arginine residues within the compounds.
JOURNAL OF PEPTIDE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Vaclav Nemec, Prashant Khirsariya, Pavlina Janovska, Paula Martin Moyano, Lukas Maier, Petra Prochazkova, Pavlina Kebkova, Tomas Gybel', Benedict-Tilman Berger, Apirat Chaikuad, Maria Reinecke, Bernhard Kuster, Stefan Knapp, Vitezslav Bryja, Kamil Paruch
Summary: In this study, a new class of potent and highly selective inhibitors of CK1 alpha, delta and epsilon were identified. MU1250, MU1500 and MU1742 were selected as quality chemical probes for those CK1 isoforms due to their optimal in vitro and in vivo profiles and exclusive selectivity. Furthermore, it was found that the central 1H-pyrrolo[2,3-b]pyridine-imidazole pharmacophore can be used as the basis of highly selective inhibitors of other therapeutically relevant protein kinases, such as p38 alpha.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Medicinal
Martin Schroeder, Matthias Leiendecker, Ulrich Graedler, Juliane Braun, Andreas Blum, Marek Wanior, Benedict-Tilman Berger, Andreas Kraemer, Susanne Mueller, Christina Esdar, Stefan Knapp, Timo Heinrich
Summary: The conserved catalytic sites in protein kinases make it difficult to find ATP competitive inhibitors with selectivity for the whole kinome. However, during a fragment campaign for focal adhesion kinase (FAK), a scaffold that lost its initial FAK affinity showed remarkable potency and selectivity for serine-arginine-protein kinases 1-3 (SRPK1-3). Non-conserved interactions with the uniquely structured hinge region of the SRPK family were the key drivers of the exclusive selectivity of the discovered fragment hit.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Cell Biology
Ganesh Babu Manoharan, Camilo Guzman, Arafath Kaja Najumudeen, Daniel Abankwa
Summary: The small GTPase Ras, frequently mutated in cancer, is a driver of tumorigenesis. Recent progress in drug-targeting Ras and understanding its organization on the plasma membrane has revealed the presence of nanoclusters. These nanoclusters, containing only a few Ras proteins, play a crucial role in recruiting downstream effectors. By using fluorescent proteins, nanoclustering of Ras can be analyzed by FRET, allowing for the identification of modulators of Ras membrane organization. In this study, homo-FRET measurements of Ras-derived constructs were implemented, providing a sensitive and advantageous approach for studying Ras-lipidation, trafficking inhibitors, and genetic perturbations of membrane anchorage proteins.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2023)
Article
Chemistry, Medicinal
Jun Yong Choi, Yoshihiko Noguchi, James M. Alburger, Simon Bayle, Eugene Chung, Wayne Grant, Apirat Chaikuad, Stefan Knapp, Derek R. Duckett, William R. Roush
Summary: Inhibiting a single kinase isoform is difficult due to the similarity of ATP-binding sites. Through studying crystal structures, a highly selective inhibitor for CK1 & epsilon; (SR-4133) was developed. The mismatch between SR-4133 and CK1 & delta; destabilizes their interaction, while the hydrophobic surface of CK1 & epsilon; enhances the binding of SR-4133, leading to selective inhibition. These potent CK1 & epsilon;-selective inhibitors exhibit nanomolar growth inhibition in bladder cancer cells and inhibit the phosphorylation of 4E-BP1, a downstream effector of CK1 & epsilon;.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Jennifer A. Amrhein, Guiqun Wang, Benedict-Tilman Berger, Lena M. Berger, Amalia D. Kalampaliki, Andreas Kraemer, Stefan Knapp, Thomas Hanke
Summary: Bone morphogenetic protein (BMP) signaling is mediated by heterotetramers formed by type-I and type-II receptors. Upon BMP binding, the constitutively active type-II receptors activate type-I receptors, leading to SMAD effector protein phosphorylation. Most drug development on receptor tyrosine kinase-like (TKL) family has focused on targeting type-I receptors, with only a few inhibitors against type-II receptors. BMPR2 is involved in multiple diseases, including pulmonary arterial hypertension, Alzheimer's disease, and cancer. This study reports the development of a selective and potent BMPR2 inhibitor 8a through macrocyclization of a promiscuous inhibitor 1 based on a 3-amino-1H-pyrazole hinge binding moiety.
ACS MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Cell Biology
Laura M. Meyer, Sebastian E. Koschade, Jonas B. Vischedyk, Marlyn Thoelken, Andrea Gubas, Martin Wegner, Marion Basoglu, Stefan Knapp, Manuel Kaulich, Stefan Eimer, Shabnam Shaid, Christian H. Brandts
Summary: The selective degradation of mitochondria through mitophagy is crucial for maintaining mitochondrial homeostasis and disease progression in acute myeloid leukemia (AML). In this study, a pairwise multiplexed CRISPR screen targeting mitophagy receptors revealed OPTN as the sole non-redundant mitophagy receptor in AML. OPTN was found to be rate-limiting for AML cell proliferation, and its loss extended overall median survival in a murine transplantation model. Mechanistically, OPTN deficiency impaired mitochondrial respiration and function, leading to increased mitochondrial ROS and a proliferation defect. These findings provide insights into the network of mitophagy receptors in AML and suggest OPTN inhibition as a potential therapeutic strategy.
Article
Chemistry, Medicinal
Emmanuel Deau, Mattias F. F. Lindberg, Freideiric Miege, Didier Roche, Nicolas George, Pascal George, Andreas Kra''mer, Stefan Knapp, Laurent Meijer
Summary: Dual-specificity,tyrosine phosphorylation-regulated kinases (DYRKs) and cdc2-like kinases (CLKs) have been identified as important targets for various pathologies. In this study, a family of DYRK/CLK inhibitors called Leucettinibs, derived from Leucettines and Leucettamine B, were synthesized and characterized. These inhibitors showed subnanomolar IC50 on DYRK1A and demonstrated potential for therapeutic drug development. Kinase-inactive isomers, iso-Leucettinibs, were also synthesized as suitable negative control compounds. Leucettinibs were found to inhibit DYRK1A substrate phosphorylation in cells.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Silvia Arifi, Julian A. Marschner, Julius Pollinger, Laura Isigkeit, Pascal Heitel, Astrid Kaiser, Lennart Obeser, Georg Hoefner, Ewgenij Proschak, Stefan Knapp, Apirat Chaikuad, Jan Heering, Daniel Merk
Summary: The lipid-sensing transcription factor PPAR γ can bind to antidiabetic TZD drugs, oxidized vitamin E metabolites, and vitamin E mimetic garcinoic acid. While the effects of the second binding on PPAR γ activity are unclear, a selective ligand of the second site has been developed, revealing potential noncanonical regulation of PPAR γ activities. This alternative binding diminishes FOXO signaling and may have therapeutic applications.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
News Item
Biochemistry & Molecular Biology
Stefan Knapp, Susanne Mueller
Summary: The quality and appropriate use of chemical tools play a crucial role in determining the quality and reliability of scientific data based on their utilization. Two papers now extend criteria to new modalities and critically review adherence to established guidelines.
NATURE CHEMICAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Janice M. Reimer, Andrea M. Dickey, Yu Xuan Lin, Robert G. Abrisch, Sebastian Mathea, Deep Chatterjee, Elizabeth J. Fay, Stefan Knapp, Matthew D. Daugherty, Samara L. Reck-Peterson, Andres E. Leschziner
Summary: Leucine Rich Repeat Kinase 1 and 2 (LRRK1 and LRRK2) are homologs in the ROCO family of proteins in humans. Despite their shared domain architecture and involvement in intracellular trafficking, they have strikingly different disease associations, with LRRK2 linked to Parkinson's disease and LRRK1 linked to bone diseases.
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Martin P. Schwalm, Andreas Kraemer, Anja Doelle, Janik Weckesser, Xufen Yu, Jian Jin, Krishna Saxena, Stefan Knapp
Summary: Cell-based assays using NanoLuciferase and HaloTag were developed to measure the kinetics and stability of PROTAC-induced degradation and ternary complex formation. Characterization of PROTACs targeting WDR5 revealed the importance of ternary complex formation and stability in the early degradation cascade. Comparison of ternary complex crystal structures highlighted the significance of an efficient E3-target interface for ternary complex stability. This study provides a strategy for the rational optimization of PROTACs using a series of live cell assays monitoring key steps of the early PROTAC-induced degradation pathway.
CELL CHEMICAL BIOLOGY
(2023)
Article
Chemistry, Medicinal
Jun Yong Choi, Yoshihiko Noguchi, James M. Alburger, Simon Bayle, Eugene Chung, Wayne Grant, Apirat Chaikuad, Stefan Knapp, Derek R. Duckett, William R. Roush
Summary: Specific inhibition of a single kinase isoform is challenging due to the high conservation of ATP-binding sites. A potent and highly CK1 epsilon-isoform-selective inhibitor (SR-4133) was developed by comparing the X-ray crystal structures of CK1 delta and CK1 epsilon. The selective inhibition of CK1 epsilon is achieved by the stable binding of SR-4133 in the ATP-binding pocket of CK1 epsilon.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Maria Karelou, Dionysis Kampasis, Amalia D. Kalampaliki, Leentje Persoons, Andreas Kraemer, Dominique Schols, Stefan Knapp, Steven De Jonghe, Ioannis K. Kostakis, Sotiris S. Nikolaropoulos
Summary: Sixteen new 2-substituted quinazolines were synthesized and evaluated for their anti-proliferative activity against multiple cancer cell lines. Compound 17 showed remarkable activity against the majority of tested cell lines.
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
