☆ 4.7 Article

Chiral magnesium(II)-catalyzed asymmetric ring-opening of meso-aziridines with primary alcohols

CHEMICAL COMMUNICATIONS (2014)

Journal

CHEMICAL COMMUNICATIONS

Volume 50, Issue 50, Pages 6672-6674

Publisher

ROYAL SOC CHEMISTRY

DOI: 10.1039/c4cc02206h

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Categories

Chemistry, Multidisciplinary

Funding

National Natural Science Foundation of China [21321061, 21172151]
Ministry of Education [20110181130014]

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Abstract

The asymmetric ring-opening of meso-aziridines with primary alcohols is realized using an N,N' -dioxide-Mg(OTf)(2) complex as the catalyst. The desired vicinal trans-beta-amino ethers are afforded in good yields and enantioselectivities. Aniline and water could also be used as the nucleophiles for the ring-opening in an identical catalyst system.

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